局部晚期头颈部鳞状细胞癌的化疗及靶向进展

doi:10.6040/j.issn.1673-3770.0.2020.276

Abstract

Abstract: Surgery in combination with chemotherapy and radiotherapy is the mainstay of treatment for locally advanced head and neck squamous cell carcinoma(LAHNSCC). However the organ preservation rate and 5-year survival rate have not significantly improved. In the late 1970s, cisplatin-based chemotherapeutic drugs began to be used in the treatment of LAHNSCC. Studies have shown a significant laryngeal preservation benefit of PF. With the application of paclitaxel, studies have confirmed that the TPF regimen has significant advantages in terms of local control and progression-free survival compared with PF. Therefore, it became the first choice for induction chemotherapy. In the early 1990s, concurrent chemoradiotherapy(CCRT)became a new method of non-surgical treatment and laryngeal protection. CCRT has clear advantages in terms of overall survival, laryngeal preservation, and local control and has been the standard non-surgical treatment for LAHNSCC. In 2006, cetuximab(CET)was approved by the US Food and Drug Administration for clinical use. Because of its advantages in terms of prognosis and less side effects, CET offers a new alternative for patients who cannot tolerate chemotherapy. This article reviews the progress in chemotherapy and targeted drug therapy for locally advanced head and neck squamous cell carcinoma.

Key words: Locally advanced head and neck squamous cell carcinoma, Chemotherapy, Induction chemotherapy, Concurrent chemoradiotherapy, Targeted therapy

CLC Number:

R735.1

WEI Ya'nan,CHEN Xi. Progress in chemotherapy and targeted drug therapy for locally advanced head and neck squamous cell carcinoma[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(3): 118-124.

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Progress in chemotherapy and targeted drug therapy for locally advanced head and neck squamous cell carcinoma

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