Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2021, Vol. 35 ›› Issue (3): 125-130.doi: 10.6040/j.issn.1673-3770.0.2020.191

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Recent research advances in the role of glutaredoxin in oculopathy

FU Yihao1,2, XU Yixuan1,2Overview,YAN Hong1,3, ZHANG Jie1Guidance   

  1. 1. Department of Ophthalmonogy, Tangdu Hospital, Air Force Medical University, Xi'an 710038, Shaanxi, China;
    2. Basic Medical School, Air Force Medical University, Xi'an 710032, Shaanxi, China;
    3. Shaanxi Eye Hospital of Xi'an Fourth Hospital, Northwestern Polytechnical University, Xi'an 710004, Shaanxi, China
  • Published:2021-05-14

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Abstract: Glutaredoxin(Grx)is animportant member of the thiol disulfide oxidoreductase protein family. The primary function is to dethiolate glutathionylated proteins, thus maintaining cellular redox homeostasis. Grx is expressed in many tissues throughout the body. In recent years, the protective function of Grx in oculopathy and its synergistic effect with other antioxidative enzymes have been increasingly elucidated, leading to a better understanding of this protein. This review summarizes the latest research on the role of Grx in oculopathy.

Key words: Glutaredoxin, Oxidative stress, Antioxidase, Cataract, Oculopathy, Gene knockout mice

CLC Number: 

  • R77
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