角膜塑形术控制儿童近视有效性与安全性的Meta分析

doi:10.6040/j.issn.1673-3770.0.2021.037

Abstract

Abstract: Objective To access the effectiveness and safety of orthokeratology(OK)on slowing myopia progression in school-aged children in different treatment duration. Methods PubMed, Cochrane Library, Embase, OVID, CNKI, Wanfang database, VIP, and CBM were searched, including randomized controlled trials(RCT)and prospective non-randomized control studies(PNC). Two reviewers independently screened literature, extracted data, and assessed the quality of included studies. The Meta-analysis was performed using RevMan 5.3 version for statistical analysis. Results 4 RCTs and 12 PNCs involving 1 453 participants were included. There were significant differences in the effect of OK group versus control group on slowing axial elongation at 0.5, 1, 1.5, 2 years follow-up periods(0.5a:MD:-0.10 mm, 95%CI: -0.12 to -0.08, P<0.001; 1a: MD: -0.18 mm, 95%CI:-0.19 to -0.17, P<0.001; 1.5a: MD: -0.21 mm, 95%CI: -0.26 to -0.15, P<0.001; 2a: MD:-0.26 mm, 95%CI: -0.30 to -0.22, P<0.001). The myopia control rate decreased with the duration of treatment. Except for the 0.5 years follow-up period, when the effect of OK lens on the reduction of axial elongation in Asian children was better than that in Caucasian, there was no statistical difference in other follow-up periods(P>0.05). The RR of incidence of adverse events in the OK and the control groups at 2-year was 5.75(95%CI:2.23 to 14.81, P=0.000 3). Conclusion Orthokeratology is an effective and safe method on controlling the progression of myopia for school-aged children. However, long-term and additional RCT studies are required to find out its continuing effectiveness.

Key words: Orthokeratology, Myopia, School-aged Children, Myopia control, Axial length, Meta-analysis

CLC Number:

R778.1

LIU Yi, YU Mingkun, SUN Wei, SHAO Zhen, HU Yuanyuan, BI Hongsheng. The effectiveness and safety of orthokeratology on controlling myopia of children: a meta-analysis[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 92-100.

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The effectiveness and safety of orthokeratology on controlling myopia of children: a meta-analysis

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