Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (5): 106-112.doi: 10.6040/j.issn.1673-3770.0.2021.374

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Research progress of anlotinib combination therapy in cancer treatment

SONG Qing1,2,3Overview,SONG Xicheng2,3,4Guidance   

  1. 1. Department of Weifang Medical University, Clinical Medical College, Weifang 261032, Shandong, China;
    2. Department of Otorhinolaryngology & Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, Shandong, China;
    3. Department of Otorhinolaryngology Laboratory, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, Shandong, China;
    4. Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai 264000, Shandong, China
  • Published:2022-09-20

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Abstract: Anlotinib is a multi-targeting tyrosine kinase inhibitor that can play an anti-tumor role by regulating angiogenesis in cancer or an immunosuppressive microenvironment. Anlotinib shows therapeutic effects in patients with advanced or recurrent cancer and has been approved for the clinical treatment of non-small cell lung cancer, soft tissue sarcoma, small cell lung cancer, medullary thyroid cancer, and other types of tumors. Clinical studies have found that anlotinib combined with chemotherapy, radiotherapy, and immune-checkpoint inhibitors could inhibit tumor growth and showed significantly better therapeutic effects than anlotinib monotherapy. In this article, we review the mechanism of action of anlotinib and the progress in research on anlotinib in combination with other cancer treatments.

Key words: Anlotinib, Combination medication, Cancer treatment, Antiangiogenesis, Immune microenvironment

CLC Number: 

  • R73
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