Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (2): 114-121.doi: 10.6040/j.issn.1673-3770.0.2022.421

• 论著 • Previous Articles    

Analysis of retinal choroidal blood flow changes and correlation with tessellated fundus in highly myopic eyes

XIONG Pianpian, WANG Jialin, SUN Jiao, ZHOU Zhuohua, WANG Yanling   

  1. Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  • Published:2023-03-30

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Abstract: Objective To observe and quantify the changes of parameters related to the macular, optic disc, and choroidal blood flow of high myopia patients with different degrees of fundus tessellation. Methods A cross-sectional study. From June 2018 to December 2018, 76 eyes of 42 individuals with high myopia were included in the study. Participants underwent color fundus photography and optical coherence tomography angiography(OCTA). The degree of tessellated fundus was assessed by an application of ETDRS grid and then divided into four groups(grade 0, grade 1, grade 2, and grade 3). The vascular density of superficial retinal capillary plexus and deep retinal capillary plexus(DCP)in the macular region, optic nerve head and radial peripapillary capillary(RPC)in the optic disc were measured by OCTA. The subfoveal choroidal thickness(SFCT), the total choroidal area(TCA), luminal area(LA), and stromal area(SA)were measured as well, and then the choroidal vascular index(CVI)was calculated. Kruskal-Wallis H test,analysis of variance, Dunnett's test, and multiple linear regression were used to analyze the collected data from the four groups. Partial correlation analysis was used to analyze the relationship between fundus tessellation and retinal choroidal blood flow parameters. Results There were significant differences in the DCP vascular density in the fovea, vascular density of RPC in the optic disc, SFCT, TCA, LA, SA, and CVI(all P<0.05). The degree of fundus tessellation was positively correlated with the vascular density of DCP in the fovea and CVI(r=0.441, 0.280,all P<0.05); while negatively correlated with the vascular density of RPC in the optic disc, SFCT, TCA, LA, and SA(r=-0.290, -0.567, -0.511, -0.475, -0.512, all P<0.05). Conclusion As the degree of fundus tessellation increases, the vascular density of the deep retinal capillary plexus in the fovea and choroidal vascular index increase as well, while the vascular density of radial peripapillary capillary in the optic disc and subfoveal choroidal thickness decrease.

Key words: High myopia, Retinal vascular density, Choroidal blood flow, Choroidal vascular index

CLC Number: 

  • R774.1
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