Abstract: Objective To investigate the changes in endoscopic and pathological indices of the lower oesophageal mucosa in patients with simple oesophageal reflux. Methods The data of patients with simple LPR and healthy controls were retrospectively analysed and observed using cytotronic endoscopy to compare the number, morphology and dilated intercellular spaces(DIS)width, cell number, cell nucleus size and cell morphology of the intrapapillary capillary loops(IPCLs)in the mucosal epithelium of the lower esophagus between the two groups, and biopsies were taken from 4 quadrants of the lower esophagus 2cm above the dentate line of the two groups using HE staining. width, cell number, nucleus size and cell morphology, and biopsies were taken from 4 quadrants 2 cm above the dentate line in the lower esophagus of the two groups, and HE staining was used to compare the two groups in terms of pathology of dilatation of intrapapillary capillaries, congestion and prolongation of papillae; hyperplasia of cells in the basal layer; infiltration of eosinophils and neutrophils; widening of the intervals between mucosal epithelium; and balloon-like expansion of epithelial cells. swelling, and statistically analysed the differences between the above groups. Results There were no significant differences in age, sex, body mass index(BMI)and disease progression between the two groups(P>0.05). There were significant differences between the two groups in the number of increased IPCLs, the width of the DIS, the number of increased cells and the size of the nucleus, as well as in the three pathological indicators of intrapillary telangiectasia, congestion, papillary elongation, eosinophilic and neutrophil infiltration and widening of the mucosal epithelial space(P<0.05). Conclusion In patients with simple pharyngopharyngeal reflux there were early endoscopic and pathological microscopic changes in the lower oesophageal mucosa.

Key words: Simple pharyngeal reflux, Cytoendoscopy, Pathology, Esophagus, Mucous