Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (6): 58-62.doi: 10.6040/j.issn.1673-3770.0.2019.546

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Correlation between Preoperative neutrophil/lymphocyte ratio and lymph node metastasis in patients with laryngeal cancer

PANG Zhenwen1, HUANG Yufeng1, YANG Aifang2, ZENG Xianjie1   

  1. 1. Department of Head and Neck Surgery, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, China;
    2. Department of Experimental Research, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, China
  • Published:2021-01-11

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Abstract: Objective To investigate the relationship between preoperative neutrophil-to-lymphocyte ratio(NLR)and lymph node metastasis in patients with laryngeal cancer. Methods A total of 102 patients with laryngeal cancer admitted to the Affiliated Cancer Hospital of Guangxi Medical University from January 2008 to December 2017 were enrolled. The preoperative NLR was used as the dependent variable to analyze the clinical pathological staging and lymph node test results of laryngeal cancer. Results The patients with preoperative NLR>2.2 has higher transfer rate and metastasis than the patients with preoperative NLR≤2.2 and the difference was significant(P<0.001).The lymph node stage of patients with preoperative NLR>2.2 was significantly higher than that of the patients with preoperative NLR≤2.2, and the difference was significant(P<0.001).The mean NLR of patients with early tumor(T1,T2)was lower than that of patients with late tumor(T3,T4), the latter had higher lymph node transfer rate and metastasis, and the difference was statistically significant(P<0.001).The mean value of NLR in clinical stage IV patients with transfer rate and metastasis were significantly higher than that of stage III, and the difference was also statistically significant(P<0.05). Among patients with supraglottic and glottic carcinoma, the preoperative NLR>2.2 group had higher lymph node metastasis rate and metastasis than NLR≤2.2 group, and the difference was statistically significant(P<0.05); There was no significant difference in lymph node metastasis for subglottic patients(P>0.05), whereas the difference in lymph node metastasis was statistically significant(P<0.05). Conclusion There is a correlation between the preoperative NLR level and lymph node metastasis in patients with laryngeal cancer, which can reflect the degree of lymph node metastasis to some extent, and provide a valuable reference for clinical treatment.

Key words: laryngeal carcinoma, clinical pathology, preoperative NLR, lymph node metastasis.

CLC Number: 

  • R765.4
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