JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2011, Vol. 25 ›› Issue (4): 8-12.

• Articles • Previous Articles     Next Articles

Significance of apoptotic and proliferative indices and  P-glycoprotein expression in laryngeal squamous cell carcinoma

LI Da-wei, DONG Pin, GAO Shang   

  1. Department of Otolaryngology-Head & Neck Surgery, Shanghai Jiaotong University  Affiliated First People′s Hospital, Shanghai 200080, China
  • Received:2011-02-28 Revised:2011-05-22 Online:2011-08-16 Published:2011-08-16

PDF (PC)

1168

Abstract:

Objective      To explore the relationship of P-glycoprotein  expression with the  apoptotic index, proliferative index, clinicopathological  characteristics, and their prognostic values in laryngeal squamous cell carcinoma (LSCC). Methods      Samples from 86 patients with LSCC were analyzed for P-glycoprotein and Ki67 expression with immunohistochemistry, and the apoptotic index with the TUNEL method. The association of P-glycoprotein  expression with clinicopathological  parameters, apoptotic and proliferative activities, and patients′ overall survival was subsequently analyzed. Results    It was found that up-regulation of P-glycoprotein expression was associated with decreased apoptosis (P＜0.05) but not with the changes in proliferation (P＞0.05). Expression of P-glycoprotein was significantly related to the clinical stage, histological grading, lymph node metastasis and overall survival in LSCC (P＜0.05). Conclusion      These results show that the overexpression of P-glycoprotein may abrogate the apoptosis of LSCC cells. Furthermore, the  results demonstrate that P-glycoprotein is predictive of malignant progression and prognosis of LSCC.

Key words: Laryngeal neoplasms; P-glycoprotein; Apoptosis; Cell proliferation; Prognosis

CLC Number: 

  • R739.65
[1] JIA Chuan-liang, WANG Li, CHEN Xiu-mei, SONG Xi-cheng. null [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(6): 83-83.
[2] LU Guo-wei， WANG Lin, SUN Yan， LI Wei， HUA Hui， GE Rui-feng. Detection of different subtypes of HPV DNA in 57 cases of laryngeal carcinoma in easter of the shandong province [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(6): 16-19.
[3] SUN Rui-jie, XU Feng-lei, LIU Da-yu, LEI Da-peng, PAN Xin-liang. Effect of CO2 laser surgery combined with interferon on recurrent juvenile laryngeal papillomatosis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(6): 23-25.
[4] CHEN Yong, XIE Xiu-fang, LIU Fang, JIANG Yi, LI Rui-yu. Treatment of laryngeal papilloma with bone marrow mesenchymal stem cells transfected with the IFN-γ gene [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(3): 24-27.
[5] ZHANG Shu-jia1, LI Pei-hua2, JIA Wen-bo1, XU Heng-guang1, BAO Feng-xiang1, LI Li1. 1. Expression and clinical significance of programmed cell death 5 (PDCD5) in laryngeal squamous cell carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(2): 23-26.
[6] WU Gui-qing1, TIAN Jun2, SUN Jing1, CHEN Qi1. 1. Expression and significance of Tiam1 and MTA1in human laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(1): 41-43.
[7] WU Hongliang1, GAO Yanyong1, YU Junxiong2, TAO Zanying3, LIU Qianghe1, HE Xiaosong1, GENG Wanping1. Effect of patient-controlled intravenous analgesia for endoscopic sinus surgery on plasma IL-6 and IL-10 [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 44-47.
[8] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(4): 73-74.
[9] XU Hong-ming， DONG Pin， SUN Zhen-feng， WANG Guo-liang， WANG Fei. Preliminary study of animal models for laryngeal surgery [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(3): 15-.
[10] YI Hai-jin1， ZHANG Bao-quan2, WANG Chun-hong1, GUO Hong1, NI Fu-qiang1. Clinical analysis and treatment of recurrent laryngeal cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(3): 18-21.
[11] LI Zhi-zhang1, LI Qin2, GENG Yu-yan3， SHAO Yang1. Effect and significance of the TGF-β1/Smad4 signaling system in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 16-.
[12] JIANG Shao-hong, SONG Xi-cheng, ZHANG Qing-quan, ZHU Yu-hong, SUN Yan, ZHANG Hua, WANG Qiang. Therapeutic effect of endoscopic sinus surgery on cyst of the  nasal sinus with an image navigation system [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 60-62.
[13] SUN Yan, SONG Xi-cheng, ZHANG Qing-quan, ZHANG Hua, LIU Zhong-lu, WANG Qiang, JIANG Shao-hong, LIU Fei-fei. Application of image navigation in maxillary sinus surgery  for benign pathological bone lesions [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(2): 63-.
[14] ZENG Zhi-mei1, LIANG Yong-hui2, YANG Yi-fang2, DOU Xiao-qing2,LUO Bi-qiang2, ZHANG Li-wei2, CHEN Xian-ming2. Expression of macrophage migration inhibitory factor  in human carcinomas of the hypopharynx [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 17-19.
[15] GAO Shang, DONG Pin, LI Da-Wei, SHEN Bin. Potential mechanism of Platelet derived growth factor-BB to  promote the proliferation and invasion of Hep2 cells [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(1): 20-23.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd