JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2015, Vol. 29 ›› Issue (2): 48-51.doi: 10.6040/j.issn.1673-3770.0.2014.369

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Expression of TSLP and its relationship with the infiltrsting regulatory T cells in chronic rhinosinusitis

ZHU Hui-tao, CAI Xiao-lan, FENG Xin, QI Jun-jun, ZHANG Jin-ling, MA Yue, LI Xue-zhong   

  1. Department of Otolaryng, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China
  • Received:2014-11-19 Online:2015-04-16 Published:2015-04-16
  • Contact: 李学忠。E-mail:lxzebyh@163.com E-mail:lxzebyh@163.com

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Abstract: Objective To determine the expression of thymic stromal lymphopoietin(TSLP)and regulatory T cells(CD4+CD25+Foxp3+Treg) in human chronic rhinosinusitis(CRS) and to analyze their pathogenesis in CRS. Methods The sinus mucosa from 25 patients with CRS was studied. Inferior nasal turbinate from 28 patients with nasal septum deviation served as the control. Their histological characteristics were analyzed by HE stain. The expressions of TSLP and Foxp3 mRNA were detected by Q-RT-PCR. Immunohistochemistry was used to detect CD4+CD25+Foxp3+Treg cells. The correlation of TSLP with the number of Tregs and the correlation of TSLP with Foxp3 mRNA were evaluated. Results The expressions of TSLP mRNA, Foxp3 mRNA and Treg cells were significant higher in CRS compared with the control group(P<0.05). There was positive correlation between TSLP and Foxp3 mRNA(r=0.977 3, P<0.000 1). At the same time, there was positive correlation between TSLP and the number of Tregs(r=0.864 6, P<0.0001). Conclusion TSLP could play an important role in CRS by inducing Treg cells.

Key words: Thymic stromal lymphopoietin, Infiltrasting regulatory T cells, Foxp3 gene, Chronic rhinosinusitis

CLC Number: 

  • R765.4
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