JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (1): 67-69.doi: 10.6040/j.issn.1673-3770.0.2015.433

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Research on diagnosis and treatment of laryngopharyngeal reflux disease.

CHEN Xun1, YANG Yun2, CHEN Zhibin1   

  1. 1. Nanjing Medical University, Nanjing 210029, Jiangsu, China;2. Department of Otolaryngology &Head Neck Surgery, Jiangsu Shengze Hospital, Suzhou 215228, Jiangsu, China
  • Received:2015-10-19 Online:2016-02-16 Published:2016-02-16

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Abstract: Objective To discuss the diagnosis and treatment method of laryngopharyngeal reflux disease(LPRD), and to observe the detection rate of helicobacter pylori from the patients with LPRD. Methods A Total of 156 LPRD patients with reflux symptom index(RSI)over 13 and/or reflux symptom index(RFS)>7 were supplied with 13C-Urea Breath Test(13C-UBT). The Hp positive patients(n=96, group I)were administrated with quadruple therapy(Omeprazole+Bismuth Potassium Citrate+Amoxicillin+Clindamycin)and Ganju Bingmei tablets for 2 weeks, followed up with a 4 weeks of withdrawal period. The primary ourcome observed was of Hp negative transformation rate and curative effect evaluation before and after the treatment; Hp negative patients were divided into group II and group III, with 30 cases in each group. The group II was given Ganju Bingmei tablets for 4 weeks and the group III was administrated with Omeprazole+Bismuth Potassium Citrate and Ganju Bingmei Tablets for 4 weeks. The main outcome was LPRD and HP negative-converting rate. Results The Hp negative-converting rate was 78.12%(75/96)in group I. The LPRD negative-converting rate in group I, group II and group III was 67.71%(65/96), 53.33%(16/30)and 96.67%(29/30), respectively.The score of RSI and RFS were decreased in all three groups after treatment, and dropped more significantly in group III(Statistic:6.73,P<0.001). Conclusion Laryngopharyngeal reflux, as an important cause of sphagitis, can be improved by using antiacid and gastrointestinal prokinetic agents.

Key words: Helicobacter pylori, Helicobacter pylori quadruple therapy, Laryngopharyngeal reflux disease, 13C-Urea Breath Test

CLC Number: 

  • R766
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