JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (2): 56-58.doi: 10.6040/j.issn.1673-3770.0.2016.042

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Expression and clinical significance of serum HMGB1 in sinusitis patients.

ZHOU Xiaoyan1,4, LIN Peng2, SUN Shiming3, ZHANG Yana2, LI Xiaojie1, SHI Yukai   

  1. 1. The First Center Clinical College of Tianjin Medical University, Tianjin 300192, China;2. Tianjin First Center Hospital, Tianjin 300192, China;3. Tianjin Medical University General Hospital, Tianjin 300052, China;4. Tianjin Dongli Chinese Medical Hospital, Tianjin 300300, China
  • Received:2016-01-28 Online:2016-04-16 Published:2016-04-16

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Abstract: Objective To investigate the expression and clinical significance of serum high mobility group box-1 protein(HMGB1)in chronic sinusitis patients. Methods A total of 32 sinusitis patients were enrolled in this study, of which 24 were type Ⅰ sinusitis, 8 were type Ⅱ sinusitis or type Ⅲ sinusitis. Meanwhile 8 healthy volunteers confirmed without infectious diseases or neoclassic diseases served as the control group. Enzyme-linked immunosorbent assays(ELISA)was applied to test cases’ serum HMGB1 level. Results (1)Sinusitis patients had higher level of serum HMGB1 than the control(P<0.05).(2)There was no significant difference of serum HMGB1 between type Ⅰ sinusitis patients and type Ⅱ and type Ⅲ sinusitis patients. Conclusion Chronic sinusitis patients have higher level of serum HMGB1 than normal people. Serum HMGB1 may serve as serum detection index for sinusitis patients. In addition, it provides the theoretic foundation for therapeutic target of sinusitis.

Key words: Enzyme-linked immunosorbent assays, High mobility group box protein, Sinusitis

CLC Number: 

  • R765.2
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