Journal of Otolaryngology and Ophthalmology of Shandong University

Operation skill and standard diagnosis and treatment are the basics of improving the curative effect of thyroid carcinoma.

FANG Jugao

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 1-4. doi:10.6040/j.issn.1673-3770.1.2016.01

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Meticulous operation of thyroid iobectomy.

GONG Shanchun, ZHANG Haidong, ZHANG Qingxiang, HE Shuangba, YU Zhenkun

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 5-9. doi:10.6040/j.issn.1673-3770.1.2016.02

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Neck dissection to differentiated thyroid carcinoma.

YU Jichun

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 10-12. doi:10.6040/j.issn.1673-3770.1.2016.03

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Treatment advance of secondary hyperthyroidism.

CHEN Jun, WANG Jiadong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 36-39. doi:10.6040/j.issn.1673-3770.1.2016.10

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Secondary hyperparathyroidism(SHPT)is a common complication of metabolic disorders in chronic kidney disease(CKD)patients. The Incidence of SHPT has increased with the passing years and the clinical manifestations are increased parathyroid hormone level, calcium-phosphorus metabolic disorders and bone pain, et al. In addition to the familiar factors, such as serum calcium and phosphorus, vitamin D and its receptor, calcium-sensing receptors, the mechanism for CKD-SHPT also includes the molecular and cellular mechanism, such as peptidyl-prolyl cis-trans isomerase 1(Pin1), Klotho protein and fibroblast growth factor-23(FGF23). Nowadays, the therapeutic strategy is mainly focused on medication, surgery and interventional therapy. This review will also introduce the pre-operation localization methods and surgical methods. Its critical to choose the suitable surgical methods for SHPT treatment.

Expressions and significance of TNF-α and IL-8 in serum and peripheral blood mononuclear cells from patients with sudden sensorineural hearing loss.

HENG Weiwei, HOU Jie, WEI Xianmei, SHE Wandong

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 40-45. doi:10.6040/j.issn.1673-3770.0.2015.473

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Objective To explore the expressions of tumor necrosis factor-α(TNF-α)and intedeukik-8(IL-8)in serum and peripheral blood mononuclear cells(PBMCs)from patients with sudden sensorineural hearing loss(SSNHL)and their clinical significance. Methods A total of 44 patients with SSNHL and 32 age-matched controls were enrolled in the study. The expressions of TNF-α and IL-8 in the serum and PBMCs were detected respectively. Results The expressions of TNF-α and IL-8 in the serum from patients with SSNHL were not much different from those in normal controls(P>0.05). However, they were significantly higher in PBMCs(P<0.05). Conclusion The elevated expressions of TNF-α and IL-8 in patients with SSNHL are closely related to the inner ear immune-mediation, indicating that inflammation may play an important role in the pathogenesis of the disease. The expressions of TNF-α and IL-8 may serve as novel diagnostic and therapeutic targets of SSNHL.

The relationship between the sinusitis and anatomic variations in ostiomeatal complex.

DENG Yuqin, YANG Yaqi, TAO Zezhang, KONG Yonggang, XU Yu, CHEN Shiming

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 46-49. doi:10.6040/j.issn.1673-3770.0.2015.432

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Objective To analyze the characteristics of chronic paranasal sinusitis CT scans and to discuss the relationship between the anatomic variations in ostiomeatal complex(OMC)and the incidence of chronic pediatric sinusitis and adult sinusitis. Methods 167 cases of diagnosised chronic sinus were selected, age 4-74. The materials of image were divided into the childhood group and the adult group, then were analyzed. Results (1)The most commonly involved sinuses were maxillary sinuses, anterior ethmoids and frontal sinuses,both in the childhood group and the adult group. (2)The results showed no definitive correlation between bony anatomic variations and sinus in children but obvious relatioship between anatomic variations and adult sinus(P<0.05). Conclusion The influence of anatomic variations on the chronic pediatric sinusitis is more greater than on the adult sinusitis. The abnormal images of the sinus cannot stand alone as diagnostic evidence of pediatric sinusitis, it can serve only as confirmatory measures of sinus disease in patients whose clincal histories are supportive of the diagnosis.

Study of autophagy-related genes atg3, ambra1 expressions in chronic rhinosinusitis without or with nasal polyps accompanied with asthma.

ZHANG Jinling, CAI Xiaolan, LI Xuezhong, FENG Xin, QI Junjun, LIU Dayu

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 50-55. doi:10.6040/j.issn.1673-3770.0.2016.064

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Objective Autophagy was an important mechanism of protection and defense in organisms. The purpose of the study was observed the expressions of autophagy-related genes Atg3 and Ambra1, investigated the relevance between autophagy, chronic rhinosinusitis(CRS)without or with nasal polyps accompanied with asthma and discussed the probable mechanisms. Methods Collection the mucosa membrane tissue of inferior turbinate in patients with nasal septum deviation(n=24)as control group, research 3 groups included mucous in ostiomeatal complex with chronic rhinosinusitis without nasal polyps(CRSsNP)(n=21), chronic rhinosinusitis with nasal polyps(CRSwNP)(n=22)and chronic rhinosinusitis with nasal polyps accompanied with asthma(CRSwNP accompanied with asthma)(n=18). The expressions of Ambra1 and Atg3 in each group were detected by Immunohistochemistry. Relevance of the autophagy-related 山东大学耳鼻喉眼学报30卷2期 -张金陵,等.自噬相关基因Atg3、Ambra1与慢性单纯性鼻窦炎、鼻息肉及鼻息肉伴发哮喘的相关性研究 \=-genes among the groups was analyzed. Results (1)The expressions of autophagy-related genes Atg3 in control group, CRSsNP group, CRSwNP group and CRSwNP accompanied with asthma group were increased gradually(χ2=31.080, P<0.001). Further pairwise comparisons in the control group with CRSsNP group(P=0.002), the control group and CRSwNP group(P<0.001), control group and CRSwNP accompanied with asthma group(P<0.001), CRSsNP group and CRSwNP accompanied with asthma group(P=0.002), CRSwNP and CRSwNP accompanied with asthma group(P=0.024)expression were statistically significant differences. However, there was not any statistically significant difference between CRSsNP group and CRSwNP group(P=0.304).(2)The expressions of autophagy-related genes Ambra1 in control group, CRSsNP group, CRSwNP group and CRSwNP accompanied with asthma group were all gradually increased(χ2=33.000, P<0.001). Further pairwise comparisons in the control group with CRSsNP group(P=0.009), control group and CRSwNP group(P<0.001), control group and CRSwNP accompanied with asthma group(P<0.001), CRSsNP group and CRSwNP accompanied with asthma group(P<0.001), CRSwNP group and CRSwNP accompanied with asthma group(P=0.009)expression were statistically significant difference, There was not any statistically significant difference between CRSsNP group and CRSwNP group(P=0.205).(3)The expressions of Atg3 and Ambra1 were positively correlated in CRSsNP group(r=0.619, P=0.003), CRSwNP group(r=0.392, P=0.022)and CRSwNP accompanied with asthma group(r=0.552, P= 0.033)(P<0.05). However, there was no statistical correlation between Atg3 and Ambra1 in the contrast group(r=0.316, P=0.133)(P>0.05). Conclusion Autophagy is closely related with the CRS pathogenesis and may be involved in the occurrence of CRSwNP accompanied with asthma. Autophagy related genes Atg3 and Ambra1 may play a synergistic role in the development of CRS. Autophagy can be considered as a potential target for the diagnosis and therapeutic treatment in CRS.

Expression and clinical significance of serum HMGB1 in sinusitis patients.

ZHOU Xiaoyan, LIN Peng, SUN Shiming, ZHANG Yana, LI Xiaojie, SHI Yukai

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 56-58. doi:10.6040/j.issn.1673-3770.0.2016.042

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Objective To investigate the expression and clinical significance of serum high mobility group box-1 protein(HMGB1)in chronic sinusitis patients. Methods A total of 32 sinusitis patients were enrolled in this study, of which 24 were type Ⅰ sinusitis, 8 were type Ⅱ sinusitis or type Ⅲ sinusitis. Meanwhile 8 healthy volunteers confirmed without infectious diseases or neoclassic diseases served as the control group. Enzyme-linked immunosorbent assays(ELISA)was applied to test cases’ serum HMGB1 level. Results (1)Sinusitis patients had higher level of serum HMGB1 than the control(P<0.05).(2)There was no significant difference of serum HMGB1 between type Ⅰ sinusitis patients and type Ⅱ and type Ⅲ sinusitis patients. Conclusion Chronic sinusitis patients have higher level of serum HMGB1 than normal people. Serum HMGB1 may serve as serum detection index for sinusitis patients. In addition, it provides the theoretic foundation for therapeutic target of sinusitis.

Tunnel flaps repairing the defects in external nasal tumor resection.

WANG Junming, SONG Xicheng, LI Dajian

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 59-61. doi:10.6040/j.issn.1673-3770.0.2016.108

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Objective To evaluate the effects of tunnel flaps to repair the defects in external nasal tumor resection. Methods A total of 27 cases of external nasal tumor were admitted into our hospital from June 2012 to June 2014. There were 18 males and 9 females, aged 31-90 years old, mean aged 59 years old, with a history of 6 months to 50 years. There were 7 cases of benign tumor, 4 cases of seborrheic keratosis, 2 cases of pleomorphic adenoma and 1 case of hemangioma. There were 20 cases of malignant tumor, 14 cases of basal cell carcinoma and 6 cases of squamous cell carcinoma. All tumors were removed by surgery. Tunnel flaps were designed to repair the defects depending on the invasion depth and location of the tumor. Results All tunnel flaps repaired the defects successfully at the primary stage and got a natural appearance and similar skin color two months later. All patients felt well at their appearances. There was only 1 case of squamous cell carcinoma recurrence, which was excised again and received radiotherapy in a 3 months to 2 years follow-up. Conclusion Tunnel flaps have a high survival rate and natural appearance in external nasal tumor resection. Patients feel satisfied at their appearance.

Clinical experience on the treatment of antrochoanal polyp under nasal endoscopy by expand road of the combined middle-inferior meatus.

LI Houjie, QU Qian, XU Shicai, LIU Lingbing, ZHANG Yongchao, WANG Xuzeng, LIU Lei

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 62-64. doi:10.6040/j.issn.1673-3770.0.2015.418

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Objective To explore the clinical effect of treating antrochoanalpolyp(ACP)under nasal endoscopy by expand road of the combined middle-inferior meatus. Methods The clinical data of 31 patients with ACP treated at department of otorhinolaryngology of the central hospital of Zaozhuang Mining Group Co. Ltd. from December 2011 to November 2014 were retrospectively analyzed. They were divided into two groups(labelled as group A and B), 14 in group A were resected through the classical wide middle meatalantrostomy by angle nasal endoscopy and 17 in group B were treated by the same method except that fractured and displacement of the inferior turbinate and combined with broadening inferior meatus and excised polyp and maxillary sinus disease under the nasal endoscope view. Results The following symptoms, such as rhinobyon, snoring, epistaxis, headache, ear stuffy disappeared in all patients. Four patients in group A were controlled portionly(28.6%), five had recurrence(35.7%)and then were included in group B. Two patients in group B controlled portionly(11.8%)and no relapse were found in group B. The control ratio was 88.2%(15/17). Conclusion The therapeutic methods used in group A and B both featured good clinical effects. The method used in group B is more advantageous with clearer view, more convenient operation, easier drainage and reexamination after surgery, better control ratio and lower recurrence rate.

Conception of successive criterion of intraoperative parathyroid hormone assay during parathyroidectomy in secondary hyperparathyroidism.

LIU Xinjie, XU Nan, CAI Wei, GAO Hengyuan, LUO Min, DENG Huiyi, ZHOU Dongxian

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 65-70. doi:10.6040/j.issn.1673-3770.0.2015.529

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Objective Evaluation of intraoperative parathyroid hormone(IOPTH)measurement for predicting successful surgery in patients undergoing near or total parathyroidectomy due to secondary hyperparathyroidism(SHPT). Methods The near or total parathyroidectomy were performed in 105 cases of SHPT. Parathyroid hormone assay were measured in operation after induction of anaesthesia but before incision(PTH₀)and 10 min(PTH₁₀)after last parathyroid was excised. The success criteria of indicating surgery in near or total parathyroidectomy were used as follow: (1) PTH₁₀≤150 pg/m, (2) a relative of PTH₁₀/PTH₀≤30%. Results 96 cases of successful operation met the criteria. Comparing to unsuccessful criteria, the decline of PTH had significant difference. Decline of calcium levels of these patients was evident after the surgery. The causing false positive rates and recurrence rates was 9.38% and 23.33% separately when it set normal PTH or low PTH as the curing criterion after 6 months follow-up. And the recurrence rates was 5% if It was PTH<300 pg/mL in the curing criterion according to K/DOQI guidelines. Decline of calcium and phosphorus in true positive cases compare to pre-operation had significant difference but it was not change in no successive criterion cases. Conclusion PTH₁₀/PTH₀≤30% was appropriate to predicte success of near or total parathyroidectomy for patients with SHPT.

The role of methylene blue in the localization of parathyroid glands in the operation of secondary hyperparathyroidism.

WANG Beibei, YANG Hong, OU Aihua

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 71-74. doi:10.6040/j.issn.1673-3770.0.2015.521

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Objective To explore the role of the positive development of methylene blue in the localization of parathyroid glands in parathyroidectomy in patients with secondary hyperthyroidism. Methods A total of 49 cases of secondary hyperparathyroidism who would undergo parathyroidectomy were randomly assigned into 2 groups: the experimental group(n=24)in which methylene blue was intravenously dripped, and the control group(n=24)without any developing method. The operation time, success rate of operation, incidence of adverse reactions, detection rate and positive predictive value of parathyroid glands were compared between the two groups. Results The operation time of the experimental group was shorter than that of the control group, the success rate was higher than that of the control group, and the differences were statistically significant(P<0.01, P=0.05). Adverse reactions associated with methylene blue occurred in 1 patient of the experimental group and 0 in the control group, and the difference was not statistically significant (P=1.00). The detection rate of the two groups were 99.00% and 92.86% respectively, with no statistical significance(P=0.03). The positive predictive values of the two groups were 97.06% and 91.92% respectively, with no statistical significance(P=0.11). Conclusion In parathyroidectomy of secondary hyperparathyroidism, methylene blue positive development can quickly, safely and effectively locate the parathyroid glands.

Clinical effect and safety of sodium aescinate combined with low dosage of prednisone in the treatment of female patients with subacute thyroiditis.

LI Cunjie, SUN Yu

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 75-77. doi:10.6040/j.issn.1673-3770.0.2015.381

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Objective To investigate the efficacyt and safety of sodium aescinate combined with low dosage of prednisone in the treatment of female patients with subacute thyroiditis. Methods A total of 80 patients with subacute thyroiditis were collected and randomly divided into the observation group and control group, with 40 cases in either group. Patients in the control group were given a total dosage of 30 mg/d oral prednisone, divided into 3 times per day. Two weeks later these patients were given a total dosage of 20 mg/d oral prednisone, divided into 3 times per day. Then the dosage was reduced by 5 mg every 2 weeks till withdrawal. Patients in the observation group were treated with 5 mg/d oral prednisone combined with 10 mg/d intravenous sodium aescinate. A 10-day course was set with an interval of 7 days. The treatment lasted for 4 weeks. The levels of thyroid stimulating hormone(TSH), free three iodine thyroid original ammonia acid(FT3), free thyroxine(FT4), red cell sedimentation rate(ESR), C-reactive protein(CRP)and fibrinogen(FIB)before treatment, 7 days, 1 month and 2 months after treatment were compared. The symptom alleviating time and incidence of adverse reactions in both groups were observed. Results Intra-group comparison: FT3, FT4, ESR, CRP, TSH levels showed statistical significances at different time points before and after treatment in the 2 groups respectively(P<0.05 or P<0.01). Inter-group comparison: ESR, CRP, TSH levels were lower in the observation group than in the control group 7 days after treatment(P<0.05 or P<0.01). FT4 and ESR levels were lower in the observation group than in the control group 1 month after treatment(P<0.01). CRP and FIB levels were lower in the observation group than in the control group 2 months after treatment(P<0.05). The symptom alleviating time and incidence of adverse reactions were lower in the observation group than in the control group(P<0.01). Conclusion Sodium aescinate combined with low dosage of prednisone is safe and effective in the treatment of subacute thyroiditis and worth of wide clinical application.

Clinical application of a newly-developed tracheal distracting clamp.

WANG Wenyi, ZHANG Qingquan, XING Yinghao

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 78-79. doi:10.6040/j.issn.1673-3770.0.2015.383

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Objective To design and develop a new surgical instrument, tracheal distracting clamp, to avoid and prevent the slippage of devices and burst of tracheal tube balloon in conventional tracheotomy. Methods The distracting clamp was designed and applied in 156 patients who underwent tracheotomy. Results During all operations, no device slippage or balloon burst occurred. Conclusion The tracheal distracting clamp can safeguard the smooth progress of tracheotomy by preventing tracheal incision complications.

Effect of the implantation of lacrimal plug for dry eyes after laser assisted in-situ keratomiLeusis.

JIANG Yang, LI Ying, WANG Zhonghai, JIN Yumei, LIU Xiaowei

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 80-83. doi:10.6040/j.issn.1673-3770.0.2015.404

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Objective To evaluate the effect of the implantation of lacrimal plug for dry eyes after laser assisted in-situ keratomi leusis(LASIK). Methods Patients with mild to moderate dry eye were included in the study before LASIK. The implantation of VisiPlug was conducted immediately after the surgery. The scores of dryness, foreign body sensation, burning sensation, photophobia, visual fatigue and blurred vision were recorded on preoperative and postoperative 1 week, 1 month and 3 months. Schirmer I test(SIt), break-up time(BUT)and corneal fluorescein staining(FS)were also tested on each time points. Results There were 130 eyes of 65 patients included in the study, including 22 males and 43 females with the average age of 28.32±7.24(18-47)years. The scores of dryness, foreign body sensation, burning sensation, photophobia, visual fatigue and blurred vision were significantly decreased on each time points after the implantation of the lacrimal plug(F value: 125.64, 263.16, 123.22, 9.80, 76.815, 105.19; P value: 0.000, 0.000, 0.000, 0.002, 0.000, 0.000). Schirmer I test(SIt), break up time(BUT)and corneal fluorescein staining(FS)were also significantly improved on each time points(F value: 45.99, 67.87, 49.01; P value: 0.000, 0.000, 0.000). There was no infection, plug in the overflow, local granulation, and the effect of corneal flap healing. Conclusion Lacrimal plug could be effective and safe in the management of dry eyes after refractive surgery.

Analysis on efficacy of treatment of corneal epithelial dysfunction after cataract surgery.

LIN Li, YANG Xu

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 84-86. doi:10.6040/j.issn.1673-3770.0.2015.366

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Objective To observe the clinical efficacy of autologous serum combined with artificial tears without preservative in the treatment of corneal epithelial dysfunction after cataract surgery. Methods Twenty-nine patients with corneal epithelial dysfunction after phacoemulsification combined with intraocular lens implantation under topical anesthesia were selected as research objects, and treated with autologous serum combined with artificial tears without preservative. The clinical manifestations of patients were observed. Slit-lamp examination and fluorescein vital staining were used to observe the conditions of conjunctival congestion, corneal epithelial repair, recession of epithelial edema and fluorescein staining, and visual function repair was compared before and after treatment. Results About 1 to 2 weeks after treatment, eye irritation symptoms of 29 patients, including ophthalmodynia, foreign body sensation in the eye and photophoby, gradually alleviated and disappeared. Slit-lamp examination revealed that conjunctival congestion improved gradually; Corneal epithelium healed, and the mean healing time was(12.60±3.91)d. Vision improved in varying degree in all cases. Conclusion Autologous serum combined with artificial tears without preservative can promote corneal epithelial healing of patients with corneal epithelial dysfunction after cataract surgery and improve the visual function.

The result of riboflavin/UVA corneal collagen cross-linking with isotonic riboflavin solution and hypotonic riboflavin solution in the treatment of keratoconus.

ZHANG Xiao, JIANG Liangzhu, XU Yanyun, MU Guoying

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 87-90. doi:10.6040/j.issn.1673-3770.0.2015.483

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The use of CEUS in the diagnosis of retinal/choroidal detachment and associated intraocular masses in patients with equivocal findings at conventional ultrasound.

QIAO Gang, DAI Yan, GUO Haike, GUO Daolin, WEI Yunfeng, LI Juan

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 91-93. doi:10.6040/j.issn.1673-3770.0.2015.420

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Objective To investigate whether contrast-enhanced ultrasound(CEUS)may help to diagnose retinal/choroidal detachment and may help to differentiate intraocular lumps in cases with equivocal features on conventional test and ultrasound. Method Clinical data of 21 patients with unclear dioptricmedia or pupillary occlusion who underwent CEUS of the eye to assess retinal/choroidal detachment and/or associated masses were analysised. The radiologic characteristic of these patients were described. The diagnosis accuracy rating of CEUS were contrasted with conventional ultrasound. Results According to the reference standard, 8 patients had retinal detachment, 6 had choroidal detachment, and 4 had vitreous opacity. There were 3 cases associated choroidal tumor. There were 6 missed diagnosis and misdiagnose. Conclusions CEUS can be used as a problem-solving technique when conventional ultrasound modes are not diagnostic for retinal/choroidal detachment and when intraocular lumps cannot be characterized as tumor or non-tumor masses on conventional modes.

Clinical observation on the effects of three surgical methods for pterygium.

WANG Dan, WANG Rui, ZHANG Qiming, WANG Liwen

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 94-97. doi:10.6040/j.issn.1673-3770.0.2015.372

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Objective To compare the therapeutic effects of simple pterygium excision, pterygium excision combined with free conjunctival flap transplantation and pterygium excision combined with autologous corneal limbus stem cell transplantation in the treatment of pterygium. Methods Totally 162 patients(186 eyes)were randomly divided into Group A, B and C. Group A were treated with simple pterygium excision, Group B with pterygium excision combined with free conjunctival flap transplantation, and Group C with pterygium excision combined with autologous corneal limbus stem cell transplantation. The recurrence rate, incidence of complications and change of tear function after surgeries were compared among the three groups. Result Group A was significantly lower than Group B and C in the cure rate, was higher than Group B and C in the incidence of complications and recurrence rate, and was longer than Group B and C in repair time(P<0.05). The incidence of complications, recurrence rate were lower and cure rate and repair time were better in Group C than those in Group B(P<0.05). The early postoperative tear films stability of Group B and C were better than that of Group A, with statistically significant difference(P<0.05). Conclusion Compared with single pterygium excision and pterygium excision combined with free conjunctival flap transplantation, pterygium excision combined with autologous corneal limbus stem cell transplantation is an effective method to treat pterygium,which can reduce the rate of complications, the recurrence,and improve tear function for patients with pterygium.

Progress of intracellular signaling pathways regulating ciliary length.

WANG Jing, WANG Xuesong, XUE Jinmei

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 98-101. doi:10.6040/j.issn.1673-3770.0.2015.550

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Cilia are located on almost all cell types of the human body, and perform key tasks for a variety of organs, but defects in the length or function of them are involved in the pathogenesis of several cilia-related disorder.Ciliary length can be regulated by the process of intraflagellar transport(IFT), signal transduction pathways,cell cycle,etc.All of these stages are tightly regulated to produce a cilium of the right size at the right time.Signaling regulation involves cAMP, NF-κB, Wnt, Shh and Notch.To further explore intracellular molecules that regulate ciliary length is of great importance for the diagnosis and treatment of certain cilia-related disorder.

Advances on genetic polymorphism of DNA double-strand break repair genes and thyroid carcinoma.

LI Yingying, SONG Xicheng

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 102-105. doi:10.6040/j.issn.1673-3770.0.2015.391

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Failure to repair DNA damage timely and effectively can lead to genome instability, which is directly related to the occurrence of tumor. DNA double-strand break(DSB)is the predominant cause of gene mutation and chromosome fragmentation. It affects the tumor susceptibility and process of carcinogenesis. The DSB repair depends mainly on homologous recombination(HR)and non-homologous end-joining(NHEJ). This paper aims to investigate the correlation between the DSB repair gene polymorphism and thyroid carcinoma susceptibility.

Massive haemorrhage of tongue base adenoid cystic carcinoma: a case report.

HU Tingbao, LIANG Jiangang

JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 106-108. doi:10.6040/j.issn.1673-3770.0.2015.392

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JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 109-109. doi:10.6040/j.issn.1673-3770.0.2015.314

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JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2016, 30(2): 110-110. doi:10.6040/j.issn.1673-3770.0.2015.549

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