Abstract: Objective To investigate the changes of lipid profiles in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)before and after upper airway surgery, and to explore whether lipid detection can be used as an intuitive and effective way to evaluate the efficacy of surgery. Methods We performed a retrospective review of adult OSAHS patients who underwent surgery at Beijing Chaoyang Hospital during 2010 to 2013 with available perioperative serum lipid profiles, and selected the data of patients who did not use lipid-lowering medications during this period. We set up preoperative period, perioperativeperiod and follow-up period as three observation point. Results A total of 19 patients were enrolled. Preoperative blood lipid examination time was(12.5±5.6)months and the follow-up was(11.8±6.2)months.There was significant difference in total cholesterol serum(TC)levels and Lipoprotein(a)levels in OSAHS patients among the three observation periods(F_TC=9.03, P_TC=0.000 7; F_LP(a)=5.49, P_LP(a)=0.009). We set the perioperative period as the baseline. Both TC and LP(a)are significantly different when compare the preoperative and follow-upperiod to perioperative period(all P<0.05). Conclusion OSAHS with intermittent hypoxia can lead to blood serum lipids disorder, which can be improved with surgical treatment. TC and LP(a)are both sensitive indicator to hypoxia. Early detection and treatment of OSAHS are essential for the prevention and treatment of cardiovascular diseases. We suggest that more cardiovascular indicators should be explored to evaluate the effectiveness of surgery. 山东大学耳鼻喉眼学报31卷1期 -葛晓辉,等.手术对阻塞性睡眠呼吸暂停低通气综合征患者血脂代谢变化的临床观察 \=-

Key words: Upperairway surgery, Blood serum lipid, Lipoprotein(a), Sleep apnea, obstructive, Total cholesterol, Triglycerides, High-density lipoprotein cholesterol, Low-density lipoprotein cholesterol, Polysomnography