JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2014, Vol. 28 ›› Issue (1): 14-16.doi: 10.6040/j.issn.1673-3770.0.2013.226

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Expression of a proliferation-inducing ligand in laryngeal squamous cell carcinoma

WEI Xi-jian1, YIN Rui-lan2, GUO Xing3   

  1. 1. Department of Otorhinolaryngology, the Central Hospital of Qingdao Jiaozhou, Jiaozhou 266300, Shandong, China; 2. Clinical laboratory, the Central Hospital of Qingdao Jiaozhou, Jiaozhou 266300, Shandong, China; 3. Department of Otorhinolaryngology, the Frist Hospital of China Medical University， Shenyang 110001,  Liaoning, China
  • Received:2013-07-23 Online:2014-02-16 Published:2014-02-16

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Abstract:

Objective   To investigate the expression of a proliferation-inducing ligand(APRIL) in laryngeal squamous cell carcinoma（LSCC）. Methods   Expression of APRIL was detected in 150 laryngeal squamous cell carcinoma samples and 150 para-carcinoma tissue by SABC immunohistochermical method.  The relationship between APRIL expression and the clinical staging of LSCC was analyzed. Results   Expression of APRIL protein in para-carcinoma tissue was 6.7%（10/150）but 89.3%（134/150）in tumor tissues.The weighted scores of APRIL in different stages of LSCC were gradually and significantly increased(P<0.05), APRIL expression level was closely associated with TNM stage（P<0.05）. Conclusion   These findings suggest that the APRIL expression are high in LSCC and significantly correlated with tumor staging.

Key words: A proliferation-inducing ligand, Immunohistochemistry, Laryngeal neoplasms

CLC Number: 

  • R766.7
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