JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2017, Vol. 31 ›› Issue (4): 68-72.doi: 10.6040/j.issn.1673-3770.0.2017.116

Previous Articles     Next Articles

Expression and clinical value of MGMT and EGFR in laryngeal squamous cell carcinoma.

ZHU Xiaocheng1, QIAN Xiaoyun2, GU Yajun2, SHEN Xiaohui2, SONG Panpan2, LI Hui2, GAO Xia   

  1. 1.School of Medicine, Southeast University, Nanjing 210009, Jiangsu, China;2.Department of Otolaryngology &Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China
  • Received:2017-03-17 Online:2017-08-16 Published:2017-08-16

PDF (PC)

424

Abstract: Objective To investigate the relationship between expression of O6-methylguanine-DNA methyltransferase(MGMT)and epidermal growth factor receptor(EGFR)in laryngeal squamous cell carcinoma(LSCC), and their relationship with clinicopathological features. Methods We collected 103 tumor tissues, detected the expression of MGMT and EGFR by immunohistochemistry(IHC), and explored their relationship with the clinicopathological features. Results The expression of MGMT in tumor tissues was positively related to differentiation degree, T stage, and clinical stage(χ2 13.302, 8.394, 11.403, P=0.001, 0.039, and 0.010, respectively). The expression of EGFR in tumor tissue was positively correlated with T stage and clinical stage(χ2 = 14.933, 16.603, P=0.002, and 0.001, respectively). Further analysis found that the expression levels of MGMT and EGFR were positively correlated(MGMT vs EGFR χ2=5.369, P=0.019). Conclusion The expression of MGMT and EGFR was correlated with T stage and clinical stage. Detecting their expression can assist in assessing the malignancy of LSCC and guide treatment.

Key words: Epidermal growth factor receptor, Laryngeal squamous cell carcinoma, O6-Methylguanine-DNA methyltransferase

CLC Number: 

  • R739.65
[1] Corry J, Rischin D, Cotton S, et al. Larynx preservation with primarynon-surgical treatment for loco-regionally advanced larynx cancer[J]. J Med Imaging Radiat Oncol, 2011, 55(2): 229-235.
[2] Hashibe M, Brennan P, Benhamou S, et al. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium[J]. J National Cancer Institute, 2007, 99(10):777-789.
[3] Burger PC, Green SB. Patient age, histologic features, and length of survival in patients with glioblastoma multiforme[J]. Cancer, 1987, 59(9):1617-1625.
[4] Grandis JR, Melhem MF, Barnes EL, et al. Quantitative immunohistochemical analysis of transforming growth factor-α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck[J]. Cancer, 1996, 78(6):1284-1292.
[5] Grandis JR, Melhem MF, Gooding WE, et al. Levels of TGF-α and EGFR protein in head and neck squamous cell carcinoma and patient survival[J]. J Natl Cancer Inst, 1998, 90(11): 824-832.
[6] Singh T, Gupta NA, Xu S, et al. Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor [J]. Oncotarget, 2015, 6(25):21268-21282.
[7] Rahman WF, Rahman KS, Nafi SN, et al. Overexpression of DNA methyltransferase 1(DNMT1)protein in astrocytic tumour and its correlation with O6-methylguanine-DNA methyltransferase(MGMT)expression[J]. Int J Clin Exp Pathol, 2015, 8(6):6095-6106.
[8] Starska K, Brys M, Forma E. Impact of EGFR immunoexpression on STAT3 activation and association with proinflammatory/regulatory cytokine pattern in laryngeal squamous cell carcinoma[J]. Oncol Rep, 2009, 21(2):539-548.
[9] Christmann M, Verbeek B, Roos W, et al. O(6)-Methylguanine- DNA methyltransferase(MGMT)in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry[J]. Biochim Biophys Acta, 2011,1816(2):179-190.
[10] 徐红超,陶静莉,许成杰,等.MGMT VEGF在脑胶质瘤中的表达及临床意义分析[J].中国实用神经疾病杂志,2016(2):41-43.
[11] Wick W, Platten M. Understanding and targeting alkylator resistance in glioblastoma[J]. Cancer Discov, 2014, 4(10):1120-1122.
[12] Wickström M, Dyberg C,Milosevic J, et al. Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance[J]. Nat Commun, 2015, 6:8904.doi: 10.1038/ncomms9904.
[13] Kontic M, Milovanovic J, Colovic Z, et al. Epidermal growth factor receptor(EGFR)expression in patients with laryngeal squamous cell carcinoma[J]. Eur Arch Otorhinolaryngol, 2015, 272(2):401-405.
[14] Agra IM, Ferlito A, Takes RP, et al. Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy[J]. Head Neck, 2012, 34(5):727-735.
[15] Orlova RV, Vaizyan RI, Ivanova AK, et al. Chemotherapy for malignant tumors: problems and prospects[J].Vopr Onkol, 2015, 61(2):244-251.
[16] Belanich M, Pastor M, Randall T, et al. Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine[J]. Cancer Res, 1996, 56(4):783-788.
[17] Esteller M, Garcia-Foncillas J, Andion E, et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents[J]. N Engl J Med, 2000, 343(19):1350-1354.
[18] Tini P, Pastina P, Nardone V, et al. The combined EGFR protein expression analysis refines the prognostic value of the MGMT promoter methylation status in glioblastoma. Clin Neurol Neurosurg, 2016, 149(10):15-21.
[1] ZHANG Mingde, ZHANG Zuping, YU Xuemin, WEI Yanhong, YUAN Ying. RASSF2A methylation in laryngeal squamous cell carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 64-67.
[2] DUAN Chen, XU Xin, SHI Li. Expressions of EGF and EGFR in nasal polyps epithelium [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(2): 31-35.
[3] JIA Chuan-liang1,2， ZHANG Li-jing2,3, SONG Xi-cheng2. MGMT gene associated with head and neck cancer [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2014, 28(3): 80-85.
[4] LIU Fang1, LAI Jian-xin1, LI Rui-yu1, LI Guan-zhen2. Th17/Treg cell ratio in the peripheral circμlation of human laryngeal squamous cell carcinoma. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(5): 4-7.
[5] XU Hai-yan1, PENG Jie-ren1, OU Yong-kang1, ZHANG Qiong-xia2, ZHANG Cun-liang1, TANG Zhi-ping1, GUAN Zhong1. Expression and clinicopathological significance of nuclear epidermal growth factor receptor, Aurora-A kinase in laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(5): 16-21.
[6] WU Gui-qing1, TIAN Jun2, SUN Jing1, CHEN Qi1. 1. Expression and significance of Tiam1 and MTA1in human laryngeal squamous cell carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2012, 26(1): 41-43.
[7] . Expression of the KAI1 gene in laryngeal carcinoma and metastasis lymph nodes [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(2): 11-13.
[8] XU Zhi-jian ,PENG Jie-ren,HUANG Xiao-ming,GUAN Zhong,ZHU Xiao-fen,LIAO Yan-ping . Expression of the Ras-GTPase-activiting protein SH 3 domain binding protein
in laryngeal squamous cell carcinoma and it clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(5): 401-404 .
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd