Abstract: Objective We aimed to assess the correlation between obstructive sleep apnea-hypopnea syndrome(OSAHS)and changes in blood glucose, serum lipid, and C-reactive protein(CRP)levels. Methods Based on the apnea-hypopnea index(AHI), 103 patients with OSAHS were divided into 3 groups, with mild(n=36), moderate(n=35), and severe disease(n=32). Thirty-five healthy subjects served as controls. Arterial oxygen saturation(SpO₂), blood glucose, serum lipid levels, and CRP levels were compared. We analyzed the correlation between AHI and SpO₂, blood glucose, serum lipid, and CRP levels. Results Compared with the control group, the lowest and average SpO₂ levels were significantly lower in all groups of OSAHS(P<0.01). Insulin resistance(IR)was high in all groups; furthermore, the fasting blood glucose(FBG), fasting insulin(FINS), CRP, and serum triglyceride(TG)levels were also significantly higher in these patients(P<0.05). Low-density lipoprotein cholesterol(LDL-C)levels were significantly higher in the moderate and severe groups(P<0.01), and increased linearly with the severity of OSAHS(P<0.01). High-density lipoprotein cholesterol(HDL-C)levels were significantly lower in all OSAHS groups and decreased linearly with disease severity(P<0.01). Total cholesterol(TC)levels were significantly higher in the severe group(P<0.05), but there was no significant difference between the 4 groups(P>0.05). AHI correlated positively with FINS levels and IR(P<0.01); it did not correlate with the lowest and average SpO₂, FINS levels, and IR(P>0.05). AHI correlated negatively with HDL-C levels(P<0.05)and positively with TG and CRP levels(P<0.01). The 山东大学耳鼻喉眼学报31卷6期 -任涛,等.阻塞性睡眠呼吸暂停低通气综合征对血糖、血脂及C反应蛋白的影响 \=-lowest and average SpO₂ correlated positively with HDL-C levels(P<0.05)and negatively with TG and CRP levels(P<0.01). Conclusion OSAHS has a strong influence on blood glucose, serum lipid, and CRP levels. The severity of OSAHS is correlated to blood glucose, serum lipid, and CRP levels. In addition, when the severity of OSAHS is based on AHI, low SpO₂ is a typical pathological feature in all groups. Besides, AHI is strongly correlated to SpO₂, IR, as well as FINS, HDL-C, TG, and CRP levels. Therefore, early screening for these markers of OSAHS may be significant in the evaluation of the disease.

Key words: C-reactive protein, Serum lipid, Hypopnea, Blood glucose, Sleep apnea, obstructive