JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2018, Vol. 32 ›› Issue (3): 23-26.doi: 10.6040/j.issn.1673-3770.1.2018.006

Previous Articles     Next Articles

Status of immunotherapy in allergic fungal rhinosinusitis

QIN Gang, LIANG Zhuoping   

  1. Department of Otolaryngology Head and Neck Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China
  • Received:2018-02-28 Online:2018-05-20 Published:2018-05-20

PDF (PC)

498

Abstract: Allergic fungal rhinosinusitis(AFRS)is an allergic disease caused by a fungus that acts as an antigen at the nasal mucosa of atopic individuals, and produces a combination of type I and III allergic reactions. The incidence of AFRS is high, and it is easy to relapse after surgery and postoperative drug treatment. There are serious impacts on the quality of life in patients. Therefore, it is of great importance to seek a safe and effective comprehensive treatment plan. Immunotherapy performed as part of comprehensive therapy can significantly improve the clinical symptoms of AFRS and reduce the requirement for corticosteroids and other drugs. The clinical value of immunotherapy is confirmed further by the finding that patients with AFRS who receive this treatment do not need repeat surgery. However, the benefits of immunotherapy remain controversial owing to conflicting research findings, and therefore these benefits warrant further investigation in clinical practice.

Key words: Allergy, Sinusitis, Fungi, Immunotherapy

CLC Number: 

  • R765.4
[1] Collins MM, Nair SB, Wormald PJ. Prevalence of noninvasive fungal sinusitis in South Australia[J]. Am J Rhinol, 2003, 17(3):127-132.
[2] Raz E, Win W, Hagiwara M, et al. Fungal sinusitis[J]. Neuroimaging Clin N Am, 2015, 25(4):569-576.
[3] Luong A, Marple BF. Allergic fungal rhinosinusitis[J]. Curr Allergy Asthma Rep, 2004, 4(6):465-470.
[4] Schubert MS. Allergic fungal sinusitis[J]. Otolaryngol Clin North Am, 2004, 37(2):301-326.
[5] Lee SH, Cho WY, Cho JY. Submucosal endoscopy, a new era of pure natural orifice translumenal endoscopic surgery(NOTES)[J]. Clin Endosc, 2012, 45(1):4-10.
[6] Campbell JM, Graham M, Gray HC, et al. Allergic fungal sinusitis in children[J]. Ann Allergy Asthma Immunol, 2006, 96(2):286-290.
[7] Prasad R, Garg R, Sanjay, et al. Concomitant allergic bronchopulmonary aspergillosis and allergic fungal sinusitis[J]. Indian J Med Sci, 2007, 61(9):532-534.
[8] Correll DP, Luzi SA, Nelson BL. Allergic fungal sinusitis[J]. Head and Neck Pathol, 2015, 9(4):488-491.
[9] Marglani O. Update in the management of allergic fungal sinusitis[J]. Saudi Med J, 2014, 35(8):791-795.
[10] Callejas CA, Douglas RG. Fungal rhinosinusitis: what every allergist should know[J]. Clin Exp Allergy, 2013, 43(8):835-849.
[11] Abbaszadegan A, Nabavizadeh M, Hoseini Yekani A, et al. Comparison of endodontic treatment results yielded from using normal saline with IKI final rinse or NaOCl irrigation: a 30-month follow-up study[J]. Iran Endod J, 2013, 8(4):171-176.
[12] 刘定荣, 史余勇, 詹先进, 等. 鼻腔结构与真菌性上颌炎关系的CT影像学研究[J]. 山东大学耳鼻喉眼学报, 2016, 30(5):94-97. LIU Dingrong, SHI Yuyong, ZHAN Xianjin, et al. Computed tomographic analysis of the relationship between nasal structure and fungal maxillary inflammation[J]. J Otolaryngol Ophthalmol Shandong Univ, 2016, 30(5):94-97.
[13] Lee SY, Yoon SH, Song WJ, et al. Influence of chronic sinusitis and nasal polyp on the lower airway of subjects without lowerairway diseases[J]. Allergy Asthma Immunol Res, 2014, 6(4):310-315.
[14] Tang J, Liu S, Zhang L, et al. Correlation analysis of prognostic and pathological features of patients with chronic sinusitis and nasal polyps following endoscopic surgery[J]. Exp Ther Med, 2013, 6(1):167-171.
[15] 康宗辉,夏思文,胡献惠, 等. 鼻内镜下中鼻道联合泪前隐窝入路治疗真菌性上颌窦炎[J]. 山东大学耳鼻喉眼学报, 2016, 30(6):33-36. KANG Zonghui, XIA Siwen, HU Xianhui, et al. Combined middle meatus and prelacrimal recess approach for treatment of fungal maxillary sinusitis[J]. J Otolaryngol Ophthalmol Shandong Univ, 2016, 30(6):33-36.
[16] Luong A, Marple B. The role of fungi in chronic rhinosinusitis[J]. Otolaryngol Clin North Am, 2005, 38(6):1203-1213.
[17] Doellman MS, Dion GR, Weitzel EK, et al. Immunotherapy in allergic fungal sinusitis: the controversy continues. A recent review of literature[J]. Allergy Rhinol(Providence), 2013, 4(1):e32-e35.
[18] Schubert MS, Hutcheson PS, Graff RJ, et al. HLA-DQB1*03 in allergic fungal sinusitis and other chronic hypertrophic rhinosinusitis disorders[J]. J Allergy Clin Immunol, 2004, 114(6):1376-1383.
[19] Chauhan B, Santiago L, Hutcheson PS, et al. Evidence for the involvement of two different MHC class Ⅱ regions in susceptibility or protection in allergic bronchopulmonary aspergillosis[J]. J Allergy Clin Immunol, 2000, 106(4):723-729.
[20] Stewart AE, Hunsaker DH. Fungus-specific IgG and IgE in allergic fungal rhinosinusitis[J]. Otolaryngol Head Neck Surg, 2002, 127(4):324-332.
[21] Gupta RP, Bahadur S, Thakar A, et al. Management protocols of Allergic Fungal Sinusitis[J]. Indian J Otolaryngol Head Neck Surg, 2007, 59(1):35-40.
[22] Dutre T, Al Dousary S, Zhang N, et al. Allergic fungal rhinosinusitis-more than a fungal disease?[J]. J Allergy Clin Immunol, 2013, 132(2):487-489.
[23] Hutcheson PS, Schubert MS, Slavin RG. Distinctions between allergic fungal rhinosinusitis and chronic rhinosinusitis[J]. Am J Rhinol Allergy, 2010, 24(6):405-408.
[24] Ragab A, Samaka RM. Immunohistochemical dissimilarity between allergic fungal and nonfungal chronic rhinosinusitis[J]. Am J Rhinol Allergy, 2013, 27(3):168-176.
[25] Luong A, Davis LS, Marple BF. Peripheral blood mononuclear cells from allergic fungal rhinosinusitis adults express a Th2 cytokine response to fungal antigens[J]. Am J Rhinol Allergy, 2009, 23(3):281-287.
[26] Collins M, Nair S, Smith W, et al. Role of local immunoglobulin E production in the pathophysiology of noninvasive fungal sinusitis[J]. Laryngoscope, 2004, 114(7):1242-1246.
[27] Manning SC, Holman M. Further evidence for allergic pathophysiology in allergic fungal sinusitis[J]. Laryngoscope, 1998, 108(10):1485-1496.
[28] Huchton DM. Allergic fungal sinusitis: an otorhinolaryngologic perspective[J]. Allergy Asthma Proc, 2003, 24(5):307-311.
[29] Singh R, Hazarika P, Nayak DR, et al. A comparison of microdebrider assisted endoscopic sinus surgery and conventional endoscopic sinus surgery for nasal polypi[J]. Indian J Otolaryngol Head Neck Surg, 2013, 65(3):193-196.
[30] Noorbakhsh S, Barati M, Farhadi M, et al. Intensive care unit nosocomial sinusitis at the Rasoul Akram Hospital: Tehran, Iran, 2007-2008[J]. Iran J Microbiol, 2012, 4(3):146-149.
[31] Al-Hashel JY, Ahmed SF, Alroughani R, et al. Migraine misdiagnosis as a sinusitis, a delay that can last for many years[J]. J Headache Pain, 2013, 14(1):97.
[32] Noorian V, Motaghi A. Assessment of the diagnostic accuracy of limited CT scan of paranasal sinuses in the identification of sinusitis[J]. Iran Red Crescent Med J, 2012, 14(11):709-712.
[33] Schubert MS. Allergic fungal sinusitis: pathogenesis and management strategies[J]. Drugs, 2004, 64(4):363-374.
[34] Mabry RL, Marple BF, Mabry CS. Outcomes after discontinuing immunotherapy for allergic fungal sinusitis[J]. Otolaryngol Head Neck Surg, 2000, 122(1):104-106.
[35] Mabry RL, Mabry CS. Allergic fungal sinusitis: the role of immunotherapy[J]. Otolaryngol Clin North Am, 2000, 33(2):433-440.
[36] Hall AG, de Shazo RD. Immunotherapy for allergic fungal sinusitis[J]. Curr Opin Allergy Clin Immunol, 2012, 12(6):629-634.
[37] Melzer JM, Driskill BR, Clenney TL, et al. Sublingual immunotherapy for allergic fungal sinusitis[J]. Ann Otol Rhinol Laryngol, 2015, 124(10):782-787.
[38] Greenhaw B, de Shazo RD, Arnold J, et al. Fungal immunotherapy in patients with allergic fungal sinusitis[J]. Ann Allergy Asthma Immunol, 2011, 107(5):432-436.
[39] Ryan MW. Allergic fungal rhinosinusitis[J]. Otolaryngol Clin North Am, 2011, 44(3):697-710.
[40] Evans MO 2nd, Coop CA. Novel treatment of allergic fungal sinusitis using Omalizumab[J]. Allergy Rhinol(Providence), 2014, 5(3):172-174.
[1] SONG Xiaoyu, ZHANG Yu, LI Chenglin, SONG Xicheng. Enhanced recovery after surgery for the treatment of chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 9-12.
[2] WANG Tan, WU Ke, LI Lianqing, GONG Lili. Factors associated with systemic adverse reactions after subcutaneous immunotherapy injections and treatment options [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 71-74.
[3] ZHANG Ruxiang, TIAN Hao, MA Youxiang. Computed tomography assessment of skull base height before endoscopic sinus surgery [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 75-77.
[4] WANG Chi, LIU Xing, KONG Lei, HONG Xinghe, NING Bo. Clinical efficacy of endoscopic plasma radiofrequency ablation in the treatment of adenoid hypertrophy and sinusitis in children and its effect on nasal mucociliary clearance [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 78-81.
[5] WU Xifu, KONG Weifeng, WANG Weihao, XU Huiqing, QI Min, YANG Qintai. Perioperative quality of life in patients with chronic rhinosinusitis with nasal polyps under enhanced recovery after surgery using QoR-15 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32(5): 5-8.
[6] QIAO Shufen, YANG Feilun, WANG Zhenni, LI Xuezhong. Relationship between YKL-40 and chronic rhinosinusitis [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 95-99.
[7] CHEN Wangxing, ZHAO Xue, LIU Yan, LIU Yue, JIN Chunshun. Psychological status of patients with deviated nasal septum or chronic sinusitis with nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 24-27.
[8] Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps. Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 28-31.
[9] CHEN Ming, YU Xuefei. Opinions on the treatment of chronic rhinosinusitis with allergic rhinitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 18-22.
[10] LOU Hongfei, WANG Chengshuo. Progress in classification of chronic sinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 10-13.
[11] LI Huabin, LAI Yuting. Pathogenesis, diagnosis, and treatment of chronic rhinosinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 4-9.
[12] ZHANG Guimin, LIN Peng. Endotype of chronic rhinosinusitis: from basic to clinical research [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 14-17.
[13] ZHANG Wei, ZENG Yuhan, YU Xiansong. Changes in nasal secretion of ECP, EGF and IL-6 in patients with chronic sinusitis before and after endoscopic sinus surgery and their clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 63-67.
[14] LI Ying. Syndrome differentiation of chronic sinusitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 27-30.
[15] LI Hongmei, WANG Lan, GAO Zhaohui, WANG Ying, XUE Jinmei. The expression and significance of p-ERK2/ ERK2 in nasal polyps [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 42-46.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd