Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 42-48.doi: 10.6040/j.issn.1673-3770.1.2018.016

• Research Progress • Previous Articles     Next Articles

Allergen inhalation challenge in the research of allergic rhinitis and asthma

Zheng ZHU,Wanjun WANG,Qiurong HU,Jing LI*()   

  1. Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, China
  • Received:2018-09-17 Online:2019-01-20 Published:2019-01-28
  • Contact: Jing LI E-mail:jingli1016@vip.163.com
  • Supported by:
    国家自然科学基金面上项目(81370129);国家自然科学基金重大研究计划培育项目(91542104);国家重点研发计划“精准医学研究”(2016YFC0905800);广州市科创局科学(技术)研究专项重点项目(201607020046);广东省科技发展专项资金(前沿与关键技术创新方向-重大科技专项)(2017B020226006)

RichHTML

166

PDF (PC)

453

Abstract:

The prevalence of allergic disease is increasing in China with the progress of urbanization and the environmental and lifestyle changes. The pathogenesis of allergic rhinitis and asthma is currently believed to be mainly caused by the interaction of genetic and environmental factors, but the specific mechanisms are not fully understood yet. Chronic airway inflammation and airway hyperresponsiveness are typical pathophysiological features of allergic rhinitis and asthma. Natural exposure to allergens in the environment can induce exacerbation of the symptoms, cause increases in airway and systemic inflammation, and lead to increased airway hyperresponsiveness. Stimulation by inhalation of allergens in patients with allergic rhinitis and asthma can induce the onset of symptoms induced by natural allergen exposure, which can be used as a model for studying the pathogenesis of allergic rhinitis and asthma and to evaluate the efficacy of treatment drugs for both conditions. As they occur in the same airway and as a single disease, allergic rhinitis and asthma impact each other. The relationship between the upper and lower airways can be examined by stimulating one end and observing the reaction of the other end of the airways. House dust mites are one of the most common allergens and well related to the severity of allergic rhinitis and asthma in China, especially in the southern areas. In this review, we summarized the application of allergen nasal and bronchial provocation in the research of allergic rhinitis and asthma.

Key words: Allergen, Rhinitis, Asthma, Inhalation challenge, Airway responsiveness

CLC Number: 

  • R765.22
1 GINA Report. Global Strategy for Asthma Management and Prevention, 2017. www.ginasthma.org.
2 Global burden of asthma. www.ginasthma.org.
3 Huggins KG , Brostoff J . Local production of specific IgE antibodies in allergic-rhinitis patients with negative skin tests[J]. Lancet, 1975, 2 (7926): 148- 150.
4 Rondón C , Romero JJ , López S , et al. Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis[J]. J Allergy Clin Immunol, 2007, 119 (4): 899- 905.
doi: 10.1016/j.jaci.2007.01.006
5 López S , Rondón C , Torres MJ , et al. Immediate and dual response to nasal challenge with Dermatophagoides pteronyssinus in local allergic rhinitis[J]. Clin Exp Allergy, 2010, 40 (7): 1007- 1014.
doi: 10.1111/j.1365-2222.2010.03492.x
6 Muller B , de Groot EJ , Kortekaas IJ , et al. Nasal epithelial cells express IL-10 at levels that negatively correlate with clinical symptoms in patients with house dust mite allergy[J]. Allergy, 2007, 62 (9): 1014- 1022.
doi: 10.1111/j.1398-9995.2007.01419.x
7 Oh JH , Hur GY , Ye YM , et al. Correlation between specific IgA and eosinophil numbers in the lavage fluid of patients with perennial allergic rhinitis[J]. Allergy Asthma Proc, 2008, 29 (2): 152- 160.
doi: 10.2500/aap.2008.29.3069
8 Riechelmann H , Epple B , Gropper G . Comparison of conjunctival and nasal provocation test in allergic rhinitis to house dust mite[J]. Int Arch Allergy Immunol, 2003, 130 (1): 51- 59.
doi: 10.1159/000068369
9 Kirerleri E , Guler N , Tamay Z , et al. Evaluation of the nasal provocation test for its necessity in the diagnosis of nasal allergy to house dust mite[J]. Asian Pac J Allergy Immunol, 2006, 24 (2/3): 117- 121.
doi: 10.1016/j.polymer.2006.09.024
10 Keck T , Wiesmiller K , Lindemann J , et al. Acoustic rhinometry in nasal provocation test in perennial allergic rhinitis[J]. Eur Arch Otorhinolaryngol, 2006, 263 (10): 910- 916.
doi: 10.1007/s00405-006-0080-4
11 Kramer MF , Jordan TR , Klemens C , et al. Factors contributing to nasal allergic late phase eosinophilia[J]. Am J Otolaryngol, 2006, 27 (3): 190- 199.
doi: 10.1016/j.amjoto.2005.09.013
12 Lopuhaä CE , de Riemer MJ , Out TA , et al. Comparison of allergen-induced late inflammatory reactions in the nose and in the skin in house dust mite-allergic patients with or without asthma[J]. Int Arch Allergy Immunol, 2003, 130 (4): 266- 274.
doi: 10.1159/000070213
13 Brown JL , Behndig AF , Sekerel BE , et al. Lower airways inflammation in allergic rhinitics: a comparison with asthmatics and normal controls[J]. Clin Exp Allergy, 2007, 37 (5): 688- 695.
doi: 10.1111/j.1365-2222.2007.02695.x
14 Andersson M , Rimmer J , Salome C , et al. Dual symptomatic and exudative nasal responses are not characteristics of perennial allergic rhinitis[J]. Acta Otolaryngol, 2001, 121 (3): 407- 413.
doi: 10.1080/000164801300102950
15 Marcucci F , Passalacqua G , Canonica GW , et al. Lower airway inflammation before and after house dust mite nasal challenge: an age and allergen exposure-related phenomenon[J]. Respir Med, 2007, 101 (7): 1600- 1608.
doi: 10.1016/j.rmed.2006.06.006
16 Tahamiler R , Saritzali G , Canakcioglu S , et al. Comparison of the long-term efficacy of subcutaneous and sublingual immunotherapies in perennial rhinitis[J]. ORL J Otorhinolaryngol Relat Spec, 2008, 70 (3): 144- 150.
doi: 10.1159/000124286
17 Tonnel AB , Scherpereel A , Douay B , et al. Allergic rhinitis due to house dust mites: evaluation of the efficacy of specific sublingual immunotherapy[J]. Allergy, 2004, 59 (5): 491- 497.
doi: 10.1111/j.1398-9995.2004.00456.x
18 Krzych-Falta E , Piekarska B , Sybilski A , et al. The safety of nasal allergen challenge test assessed in lower airways[J]. Iran J Allergy Asthma Immunol, 2015, 14 (6): 581- 588.
19 Wang W , Xian M , Xie Y , et al. Aggravation of airway inflammation and hyper-responsiveness following nasal challenge with Dermatophagoides pteronyssinus in perennial allergic rhinitis without symptoms of asthma[J]. Allergy, 2016, 71 (3): 378- 386.
doi: 10.1111/all.12808
20 Wang DY , Goh DY , Ho AK , et al. The upper and lower airway responses to nasal challenge with house-dust mite Blomia tropicalis[J]. Allergy, 2003, 58 (1): 78- 82.
doi: 10.1034/j.1398-9995.2003.23746.x
21 Smith SG , Gugilla A , Mukherjee M , et al. Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma[J]. J Allergy Clin Immunol, 2015, 135 (6): 1594- 1602.
doi: 10.1016/j.jaci.2014.12.1918
22 Lopuhaä CE , Koopmans JG , Jansen HM , et al. Similar levels of nitric oxide in exhaled air in non-asthmatic rhinitis and asthma after bronchial allergen challenge[J]. Allergy, 2003, 58 (4): 300- 305.
doi: 10.1034/j.1398-9995.2003.00075.x
23 Diamant Z , Gauvreau GM , Cockcroft DW , et al. Inhaled allergen bronchoprovocation tests[J]. J Allergy Clin Immunol, 2013, 132 (5): 1045- 1055.e6.
doi: 10.1016/j.jaci.2013.08.023
24 Agache I , Bilò M , Braunstahl GJ , et al. In vivodiagnosis of allergic diseases-allergen provocation tests[J]. Allergy, 2015, 70 (4): 355- 365.
doi: 10.1111/all.12586
25 Li J , Sun B , Huang Y , et al. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J]. Allergy, 2009, 64 (7): 1083- 1092.
doi: 10.1111/j.1398-9995.2009.01967.x
26 Klimek L , Hoffmann HJ , Renz H , et al. Diagnostic test allergens used for in vivo diagnosis of allergic diseases are at risk: a European Perspective[J]. Allergy, 2015, 70 (10): 1329- 1331.
doi: 10.1111/all.12676
27 de Groot H GvWR. In-vivo diagnostiek: bronchiale provocative[M]. In: Bruijnzeel-Koomen CA, editor. Handboek Allergologie. Utrecht: De TIjdstroom 2008: 21-24.
28 Cockcroft DW , Ruffin RE , Frith PA , et al. Determinants of allergen-induced asthma: dose of allergen, circulating IgE antibody concentration, and bronchial responsiveness to inhaled histamine[J]. Am Rev Respir Dis, 1979, 120 (5): 1053- 1058.
doi: 10.1164/arrd.1979.120.5.1053
29 Casset A , Purohit A , Birba E , et al. Bronchial challenge test in asthmatics sensitized to mites: role of particle size in bronchial response[J]. J Aerosol Med, 2007, 20 (4): 509- 518.
doi: 10.1089/jam.2007.0591
30 Barnig C , Purohit A , Casset A , et al. Nonallergic airway hyperresponsiveness and allergen-specific IgE levels are the main determinants of the early and late asthmatic response to allergen[J]. J Invest Allergy Clin Immunol, 2013, 23 (4): 267- 274.
doi: 10.1159/000346530
31 Boulet LP , Gauvreau G , Boulay ME , et al. Allergen-induced early and late asthmatic responses to inhaled seasonal and perennial allergens[J]. Clin Exp Allergy, 2015, 45 (11): 1647- 1653.
doi: 10.1111/cea.12587
32 Fairfax AJ , Hanson JM , Morley J . The late reaction following bronchial provocation with house dust mite allergen. Dependence on arachidonic acid metabolism[J]. Clin Exp Immunol, 1983, 52 (2): 393- 398.
doi: 10.1016/0008-8749(83)90337-4
33 Asosingh K , Hanson JD , Cheng G , et al. Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: a blood-borne cellular envoy for lung eosinophilia[J]. J Allergy Clin Immunol, 2010, 125 (4): 918- 925.
doi: 10.1016/j.jaci.2010.01.017
34 El-Gammal A , Oliveria JP , Howie K , et al. Allergen-induced changes in bone marrow and airway dendritic cells in subjects with asthma[J]. Am J Respir Crit Care Med, 2016, 194 (2): 169- 177.
doi: 10.1164/rccm.201508-1623oc
35 Hong GH , Kwon HS , Moon KA , et al. Clusterin modulates allergic airway inflammation by attenuating CCL20-mediated dendritic cell recruitment[J]. J Immunol, 2016, 196 (5): 2021- 2030.
doi: 10.4049/jimmunol.1500747
36 Panganiban RP , Wang YL , Howrylak J , et al. Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma[J]. J Allergy Clin Immunol, 2016, 137 (5): 1423- 1432.
doi: 10.1016/j.jaci.2016.01.029
37 Lopuhaä CE , Out TA , Jansen HM , et al. Allergen-induced bronchial inflammation in house dust mite-allergic patients with or without asthma[J]. Clin Exp Allergy, 2002, 32 (12): 1720- 1727.
doi: 10.1046/j.1365-2222.2002.01542.x
38 Alvarez MJ , Olaguibel JM , Garcia BE , et al. Comparison of allergen-induced changes in bronchial hyperresponsiveness and airway inflammation between mildly allergic asthma patients and allergic rhinitis patients[J]. Allergy, 2000, 55 (6): 531- 539.
doi: 10.1034/j.1398-9995.2000.00534.x
39 Krug N , Hohlfeld JM , Kirsten AM , et al. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme[J]. N Engl J Med, 2015, 372 (21): 1987- 1995.
doi: 10.1056/NEJMoa1411776
40 van Rensen EL , Evertse CE , van Schadewijk WA , et al. Eosinophils in bronchial mucosa of asthmatics after allergen challenge: effect of anti-IgE treatment[J]. Allergy, 2009, 64 (1): 72- 80.
doi: 10.1111/j.1398-9995.2008.01881.x
41 Singh D , Richards D , Knowles RG , et al. Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma[J]. Am J Respir Crit Care Med, 2007, 176 (10): 988- 993.
doi: 10.1164/rccm.200704-588OC
42 Hesslinger C , Strub A , Boer R , et al. Inhibition of inducible nitric oxide synthase in respiratory diseases[J]. Biochem Soc Trans, 2009, 37 (Pt 4): 886- 891.
doi: 10.1042/BST0370886
43 Tworek D , Smith SG , Salter BM , et al. IL-25 receptor expression on airway dendritic cells after allergen challenge in subjects with asthma[J]. Am J Respir Crit Care Med, 2016, 193 (9): 957- 964.
doi: 10.1164/rccm.201509-1751OC
[1] Hongmeng YU,Zhuofu LIU,Qi DAI. Endoscopic sinus surgery for chronic sinusitis with asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 38-41.
[2] Jie SHAO. Problems associated with allergic asthma in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 25-27.
[3] QIN Ya′nan, WANG Lin, JIANG Yan, YAN Shu, CHEN Min, YU Longgang, LI Na. Characteristics of the distribution of inhaled allergens in patients with allergic rhinitis in Qingdao from 2008 to 2017 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 67-72.
[4] Yu ZHANG,Xicheng SONG. Advances in interaction mechanisms and treatment strategy between chronic rhinosinusitis with nasal polyp and asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 49-52.
[5] DU Jingwei, FENG Jun, MA Peng, LI Zhiyong, LI Hongguang. Effect of nasal irrigation combined with intranasal corticosteroids to treat allergic rhinitis and influence on exhaled nitric oxide and lung function [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 124-127.
[6] HONG Dongdong, LIU Yuanxian, ZOU Lianqiang, WENG Juanling, DENG Wenxian. An analysis of 764 positive skin prick test results for Dermatophagoides farinae in patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 119-123.
[7] QI Yan, LIU Junqi, PENG Shuya, LUO Kai, ZHANG Mingxia, WANG Zhenlin. Therapeutic ecacy of endoscopic elective vidian neurectomy for moderate-severe persistent allergic rhinitis with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 109-113.
[8] Kai GUAN,Lianglu WANG. Overall diagnosis and treatment strategy for allergic diseases related to hay fever [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 13-19.
[9] Yinshi GUO,Hui LU. Research progress of group Ⅱ innate lymphoid cells in the allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 9-12.
[10] Chuanhe LIU. The prevalence, diagnosis and management of asthma in children in China [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 28-32.
[11] CAO Cheng, XU Yu. Clinical compliance and related factors to sublingual immunotherapy in patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 114-118.
[12] Qianhui QIU,Junxiao GAO. Synchronous control and long-term efficacy of specific immunotherapy for allergic rhinitis and asthma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 33-37.
[13] Li SHA,Chuanhe LIU. Research progress in the treatment of bronchial asthma with biological agents [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 53-58.
[14] JIN Xing, HU Dayu, ZHU Li, DENG Furong, LIU Junxiu. Correlation between PM2.5 and upper airway resistance in patients with allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 77-80.
[15] LI Lisha, GUAN Kai, WANG Zixi, CUI Le. The effects of air pollutants on the severity of allergic rhinitis symptoms caused by cypress pollen [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(1): 81-87.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] LIN Bin,WANGHui-ge . Functional endoscopic sinus surgery, FESS[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(6): 481 -487 .
[2] YANG Changliang,HUANG Zhiwu,YAO Hangqi,ZHU Yong,SNU Yi . Study on auditory brainstem response[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 9 -13 .
[3] LUAN Jiangang,LIANG Chuanyu,WEN Yanjun,LI Jiong . Construction of RNAi expressing plasmid vector of pSIRENshuttle for EGFR gene silencing[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 4 -8 .
[4] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(2): 188 -188 .
[5] WAN Li-jia,LU Hai-tao,JIANG Yi-dao,LIU Hui,LI Qin,SHE La-zhi . Effect of H-uvulopalatopharyngoplasty on obstructive sleep apnea
hypopnea syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 204 -205 .
[6] WANG Xiao-feng,LIN Chang,CHENG Jin-mei . Expression of ABAD in inner ears and its clinical significance in different age mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 207 -211 .
[7] LIU Yan,LIU Xin-yi,WANG Jin-ping,LI Da-jian . Measurement of the posterior tympanum and its clinical significance [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 218 -221 .
[8] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 222 -224 .
[9] LIU Qiang-he,LUO Xiang-lin,GENG Wan-ping,CHEN Chen,LEI Xun,LIU Fang-xian,DENG Ming . Age-related spiral ganglion neuron damages and hearing loss in senescence accelerated mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 215 -217 .
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 227 -227 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd