Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (2): 31-34.doi: 10.6040/j.issn.1673-3770.0.2019.072

• Research Progress • Previous Articles     Next Articles

Treatment of radiation-induced carcinoma in patients with nasopharyngeal carcinoma

Rui CHEN1,Jieen LI2,*()   

  1. 1. Department of Otolaryngology, the First Affiliated Hospital of Guangxi University of Science and Technology, Liuzhou 545002, Guangxi, China
    2. Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China
  • Received:2019-02-10 Online:2019-03-20 Published:2019-03-28
  • Contact: Jieen LI E-mail:1310715240@qq.com

RichHTML

12

PDF (PC)

504

Abstract:

Radiotherapy is currently the main treatment modality for nasopharyngeal carcinoma; however, post-radiotherapy, there is considerable risk of development of radiation-induced malignant tumors in the patients. In this paper, we have reviewed the diagnosis, pathogenesis, age and incubation period, pathological types, predilection sites, treatment, and prognosis of radiation-induced tumors.

Key words: Nasopharyngeal neoplasms, Radiotherapy, Complications, Induced malignant carcinoma

CLC Number: 

  • R739.6
1 Kirova YM , Vilcoq JR , Asselain B , et al. Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution review[J]. Cancer, 2005, 104 (4): 856- 863.
doi: 10.1002/cncr.21223
2 刘新帆.电离辐射的诱发恶性肿瘤效应[M]//殷尉伯,谷铣之.肿瘤放射治疗学.北京:中国协和医科大学出版社, 2002: 35.
3 马缠过, 杨克强. 放射治疗诱发恶性肿瘤32例分析[J]. 中华放射肿瘤学杂志, 2000, 9 (2): 108- 109.
doi: 10.3760/j.issn:1004-4221.2000.02.010
MA Changuo , YANG Keqiang . 32 cases of radiation induced malignant tumor[J]. Chinese Journal of Radiation Oncology, 2000, 9 (2): 108- 109.
doi: 10.3760/j.issn:1004-4221.2000.02.010
4 刘永华, 韩铭钧, 柳学国, 等. 进展期贲门癌术前胃左动脉化疗栓塞的临床应用[J]. 中国肿瘤临床与康复, 2004, 11 (3): 231- 232.
doi: 10.13455/j.cnki.cjcor.2004.03.015
LIU Yonghua , HAN Mingjun , LIU Xueguo , et al. Left gastric arterial chemoembolization in the treatment of advanced cardiac carcinoma before operation[J]. Chinese Journal of Clinical Oncology and Rehabilitation, 2004, 11 (3): 231- 232.
doi: 10.13455/j.cnki.cjcor.2004.03.015
5 Kleinerman RA , Tucker MA , Tarone RE , et al. Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up[J]. J Clin Oncol, 2005, 23 (10): 2272- 2279.
doi: 10.1200/JCO.2005.05.054
6 Redpath JL . Radiation-induced neoplastic transformation in vitro: evidence for a protective effect at low doses of low LET radiation[J]. Cancer Metastasis Rev, 2004, 23 (3/4): 333- 339.
doi: 10.1023/B:CANC.0000031771.56142.9b
7 Steeves RA , Bataini JP . Neoplasms induced by megavoltage radiation in the head and neck region[J]. Cancer, 1981, 47 (7): 1770- 1774.
doi: 10.1002/(ISSN)1097-0142
8 陈铭忠, 杨云利. 鼻咽癌放射治疗后后遗症129例临床分析[J]. 广西医科大学学报, 1997, 14 (4): 113- 115.
doi: 10.16190/j.cnki.45-1211/r.1997.04.045
9 马代远, 王仁生. 鼻咽癌放疗后诱发恶性肿瘤85例临床分析[J]. 中国辐射卫生, 2007, 16 (2): 236- 237.
doi: 10.3969/j.issn.1004-714X.2007.02.061
MA Daiyuan , WAaNG Rensheng . Clinical analysis of 85 cases of radiation-induced tumors due to nasopharyngeal carcinoma undergone radio therapy[J]. Chinese Journal of Radiological Health, 2007, 16 (2): 236- 237.
doi: 10.3969/j.issn.1004-714X.2007.02.061
10 Malone JP , Levin RJ . Second malignant tumors after treatment of nasopharyngeal carcinoma: four case reports and literature review[J]. Skull Base, 2002, 12 (2): 87- 91.
doi: 10.1055/s-2002-31576-1
11 王海霞, 刘孟忠, 何立儒, 等. 鼻咽癌放疗后诱发的恶性肿瘤(附198例报道)[J]. 中国肿瘤临床, 2008, 35 (6): 313- 316.
doi: 10.3969/j.issn.1000-8179.2008.06.004
WANG Haixia , LIU Mengzhong , HE Liru , et al. Malignancies induced by radiation therapy for nasopharyngeal carcinoma-a report of 198 cases[J]. Chinese Journal of Clinical Oncology, 2008, 35 (6): 313- 316.
doi: 10.3969/j.issn.1000-8179.2008.06.004
12 Wiklund TA , Blomqvist CP , Räty J , et al. Postirradiation sarcoma. Analysis of a nationwide cancer registry material[J]. Cancer, 1991, 68 (3): 524- 531.
doi: 10.1002/(ISSN)1097-0142
13 Laskin WB , Silverman TA , Enzinger FM . Postradiation soft tissue sarcomas. An analysis of 53 cases[J]. Cancer, 1988, 62 (11): 2330- 2340.
doi: 10.1002/(ISSN)1097-0142
14 Yamamoto E , Shibuya H , Yoshimura R , et al. Site specific dependency of second primary cancer in early stage head and neck squamous cell carcinoma[J]. Cancer, 2002, 94 (7): 2007- 2014.
doi: 10.1002/cncr.v94:7
15 Teo PM , Chan AT , Leung SF , et al. Increased incidence of tongue cancer after primary radiotherapy for nasopharyngeal carcinoma: the possibility of radiation carcinogenesis[J]. Eur J Cancer, 1999, 35 (2): 219- 225.
doi: 10.1016/S0959-8049(98)00386-4
16 张家钰. 放射治疗诱发恶性肿瘤[J]. 中华放射医学与防护杂志, 1998, (2): 138.
doi: 10.3760/cma.j.issn.0254-5098.1998.02.032
17 杨云利, 刘颖新, 陆海杰, 等. 鼻咽癌放射治疗后诱发第二肿瘤临床分析[J]. 肿瘤防治研究, 2003, 30 (1): 60- 61.
doi: 10.3971/j.issn.1000-8578.2003.01.023
YANG Yunli , LIU Yingxin , LU Haijie , et al. 18 cases of radiation induced malignant tumor in nasopharyngeal carcinoma[J]. Cancer Research on Prevention and Treatment, 2003, 30 (1): 60- 61.
doi: 10.3971/j.issn.1000-8578.2003.01.023
18 伍国号, 陈福进, 曾宗渊, 等. 放射诱发的第二原发性恶性肿瘤的临床治疗[J]. 中华肿瘤杂志, 2003, 25 (3): 275- 277.
doi: 10.3760/j.issn:0253-3766.2003.03.020
WU Guohao , CHEN Fujin , ZENG Zongyuan , et al. Treatment of second primary malignant tumor induced by radiotherapy[J]. Chinese Journal of Oncology, 2003, 25 (3): 275- 277.
doi: 10.3760/j.issn:0253-3766.2003.03.020
19 Maisel . Radiotherapy induce head-neck sarcoma[J]. Ear Nose and Throat Journal, 1995, 35 (1): 12- 16.
20 King AD , Ahuja AT , Teo P , et al. Radiation induced sarcomas of the head and neck following radiotherapy for nasopharyngeal carcinoma[J]. Clin Radiol, 2000, 55 (9): 684- 689.
doi: 10.1053/crad.2000.0503
21 Xi M , Liu MZ , Wang HX , et al. Radiation-induced sarcoma in patients with nasopharyngeal carcinoma: a single-institution study[J]. Cancer, 2010, 116 (23): 5479- 5486.
doi: 10.1002/cncr.25329
22 Chan JY , Wong ST , Lau GI , et al. Postradiation sarcoma after radiotherapy for nasopharyngeal carcinoma[J]. Laryngoscope, 2012, 122 (12): 2695- 2699.
doi: 10.1002/lary.23282
[1] Yan JIANG. Recurrence of nasopharyngeal carcinoma and application of endoscopic surgery [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 1-11.
[2] Dongping CHEN,Zhihuan YANG,Yan ZHANG,Nan FANG,Bin QI. Status of surgical treatment for recurrent nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 12-16.
[3] Qianhui QIU,Zhuo CHEN. Endoscopic surgery for the treatment of locally advanced nasopharyngeal carcinoma and serious complications after radiotherapy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 17-20.
[4] Zhenlin WANG,Junqi LIU. Protection of the internal carotid artery during surgery for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 21-25.
[5] Haijun LU,Ji LIU,Xiao DING. Progress in the comprehensive treatment for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 26-30.
[6] Wenrui XU,Yan JIANG. Surgery Treatment for Recurrent Nasopharyngeal Carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 35-38.
[7] Quan LIU,Xicai SUN,Huapeng YU,Keqing ZHAO,Huankang ZHANG,Weidong ZHAO,Yurong GU,Houyong LI,Dehui WANG,Hongmeng YU. Types of endoscopic transnasal nasopharyngectomy for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 39-45.
[8] Junxiao GAO,Qianhui QIU. Efficacy of endoscopic surgery using two types of flaps to reconstruct the skull base after radiotherapy for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 46-50.
[9] Lijuan ZHAO,Yan JIANG,Longgang YU,Liang CAI,Min CHEN,Jisheng ZHANG,Zhiyuan LI,Jianbao JU,Na LI. Clinical analysis of endoscopic surgery for nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 51-56.
[10] Xiaohan SUN,Na LI. Introduction to the SEOM clinical guidelines for nasopharyngeal cancer (2017) [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 57-59.
[11] WANG Jun, XING Fenli, ZHU Ping, SUN Yaping, TANG Cuiju. Comparison of two nasal irrigation methods during radiotherapy in patients with nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 60-63.
[12] LIU Jianbo, ZHANG Huan. Phacoemulsification combined with intravitreal ranibizumab or triamcinolone acetonide injection for the treatment of cataract accompanied by diabetic macular edema [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 99-104.
[13] JIANG Xiuying, LI Yuanbin. Clinical analysis of posterior intraocular lens dislocation [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(2): 105-110.
[14] HUO Hong, LI Wuyi, WANG Jian, YANG Dahai, JIN Xiaofeng, TIAN Xu, NIU Yanyan.. Treatment of pharyngeal stenosis following uvulopalatopharyngoplasty with coblation. [J]. J Otolaryngol Ophthalmol Shandong Univ, 2017, 31(6): 58-61.
[15] . Effects of concurrent chemotherapy and radiotherapy on the quality of life in children and adolescents with nasopharyngeal carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(2): 55-58.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] LIN Bin,WANGHui-ge . Functional endoscopic sinus surgery, FESS[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(6): 481 -487 .
[2] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 89 -89 .
[3] LUAN Jiangang,LIANG Chuanyu,WEN Yanjun,LI Jiong . Construction of RNAi expressing plasmid vector of pSIRENshuttle for EGFR gene silencing[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 4 -8 .
[4] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 90 -91 .
[5] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(2): 188 -188 .
[6] MENG Qing-guo,LU Yong-tian,FAN Xian-liang .

Association of killer cell immunoglobulin-like receptor gene polymorphisms with nasopharyngeal carcinoma

[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 196 -199 .
[7] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 200 -203 .
[8] LIU Qiang-he,LUO Xiang-lin,GENG Wan-ping,CHEN Chen,LEI Xun,LIU Fang-xian,DENG Ming . Age-related spiral ganglion neuron damages and hearing loss in senescence accelerated mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 215 -217 .
[9] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 227 -227 .
[10] LIN Feng,LIANG Yong,LU Yong-tian,WAN Li-xia . Classification and surgical treatment for nasal inverted papilloma[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 231 -233 .
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd