Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (5): 158-161.doi: 10.6040/j.issn.1673-3770.0.2018.606

• Review • Previous Articles    

Autophagy and its research progress in glaucoma

Ruibao LIU,Ying ZHAO,Minglu GUO,Yu DUAN,Yanxia WU,Xuejing LU()   

  1. College of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
  • Received:2018-12-19 Revised:2019-05-18 Online:2019-09-20 Published:2019-10-15
  • Contact: Xuejing LU E-mail:xgl214@126.com

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Abstract:

Autophagy is a cellular metabolic process in which cells degrade and renew abnormal proteins, glycogen, damaged organelles, and other accumulations and release small molecules favorable for secondary utilization by cells to maintain intracellular homeostasis. It is a unique life phenomenon in eukaryotic cells and plays an important role in cell growth, development, and aging. Activation of abnormal autophagy is associated with various diseases, including tumor, immune disorders, and neurodegenerative diseases, in the human body. In recent years, it has been found that autophagy is involved in the physiological and pathological process of glaucoma; however, whether autophagy promotes the survival or death of retinal ganglion cells remains controversial. Therefore, an in-depth study on the occurrence and mechanism of autophagy is of great significance for a comprehensive understanding of the role of autophagy in the pathogenesis of glaucoma.

Key words: Autophagy, Neurodegenerative diseases, Glaucoma

CLC Number: 

  • R774
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