Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (5): 162-165.doi: 10.6040/j.issn.1673-3770.0.2019.240

• Brief Report • Previous Articles    

A retrospective study on clinic manifestation and pathological of the larynx leukoplakia in 76 cases

Yangfan LIU1,Jian JIA2,Baoluo WAN1()   

  1. 1. Department of Otorhinolaryngology Head and Neck Surgery, The People′s Hospital of Zhengzhou University，Henan Provincial People′s Hospital, Zhengzhou 450003, He′nan, China
    2. Department of Otorhinolaryngology, People′s Hospital of Xixian，Xixian 464300，He′nan, China
  • Received:2019-05-10 Revised:2019-05-31 Online:2019-09-20 Published:2019-10-15
  • Contact: Baoluo WAN E-mail:wanbaoluo2013 @126.com

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Key words: Leukoplakia, Pathological type, Prognosis, Dysplasia

CLC Number: 

  • R767

Fig. 1

Laryngoscopy results. a：White protruding lesion throughout the right vocal cord and at the front of the left vocal cord, the surface was not smooth. b：White lesion visible in the middle of the right vocal cord and the vocal cord are obviously congested，the surface was not smooth."

Fig. 2

Pathological manifestations. a：Squamous epithelial proliferated actively，moderate or severe dysplasia cells(hematoxylin-eosin staining, ×100). b: Severe hyperplasia in the squmous metaplastic epithelium(hematoxylin-eosin staining, ×100)."

Table 1

The clinical features, pathological type and prognosis in 76 patients [n(%)]"

临床因素 例数 复发 恶变
性别
男 71（93.42） 10（90.91） 5（100）
女 5（6.58） 1（9.09） 0（0）
年龄
<40 4（55.56） 1（9.09） 0（0）
≥40 72（44.44） 10（90.91） 5（100）
吸烟
是 61（80.26） 10（90.91） 5（100）
否 15（19.74） 1（9.09） 0（0）
饮酒
是 54（71.05） 9（81.82） 5（100）
否 22（28.95） 2（18.18） 0（0）
咽喉反流
是 39（51.32） 8（72.73） 4（75）
否 37（48.68） 3（27.27） 1（25）
病理类型
鳞状上皮单纯增生 33（43.42) 3（27.27） 0（0）
轻度异型增生 21(27.63) 4（36.36） 2（40）
中度异型增生 13（17.11） 2（18.18） 1（20）
重度异型增生 7（9.21） 2（18.18） 2（40）
原位癌 2（2.63） 0（0） （0）

Table 2

Analysis of disease factors in observation group and control group [n(%)]"

组别 例数 吸烟 饮酒 咽喉反流
病例组 76 61（80.26） 54（71.05） 39（51.32）
对照组 40 13（32.5） 9（22.5） 7（17.5）
χ2 - 25.884 24.897 12.523
P - <0.001 <0.001 0.001
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