JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (6): 90-93.doi: 10.6040/j.issn.1673-3770.0.2016.061

Previous Articles     Next Articles

Discussion on the relationship between vocal cord leukoplakia and premalignant lesions and research progress of vocal cord leukoplakia.

WANG Yalin1, CHEN Jianqiu2   

  1. 1. Second Clinical College of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong, China;2. Department of Otolaryngology &Head and Neck Surgery, General Hospital of Jinan Military Region, Jinan 250031, Shandong, China
  • Received:2016-02-20 Online:2016-12-16 Published:2016-12-16

Abstract: Vocal cord leukoplakia is a white-plaque disease due to long-term stimulation on vocal cords, which includes abnormal epithelial hypertrophy and dysplasia of the vocal cord. The term “white plaque” is clinically describing any white lesion on a mucous membrane that cannot be wiped off or ascribed to any specific condition(eg, Candidal infection). There is a consensus that vocal cord leukoplakia has no histologic implications and synonymous with cancer or malignancy, only as a clinical descriptive diagnosis. In this paper, we reviewed the relationship between vocal cord leukoplakia and premalignant lesions and the formation mechanism, histopathologic classification, clinical diagnosis and treatment of vocal cord leukoplakia.

Key words: Vocal cord leukoplakia, Premalignant lesions

CLC Number: 

  • R762
[1] Pelucchi C, Gallus S, Garavello W, et al. Alcohol and tobacco use, and cancer risk for upper aero digestive tract and liver[J]. Eur J Cancer Prev, 2008, 17(4):340-344.
[2] Weller M D, Nankivell P C, Mcconkey C, et al. The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis[J]. Clin Otolaryngol, 2010, 35(5):364-372.
[3] van Hulst A M, Kroon W, van der Linden E S, et al. Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions[J]. Head Neck, 2016, 38(1):2284-2290.
[4] Jackson C. Cancer of the larynx: is it preceded by a recognizable precancerous condition?[J]. Ann Surg, 1923, 77(1):1-14.
[5] Mehanna H, Paleri V, Robson A, et al. Consensus statement by otorhinolaryngologists and pathologists on the diagnosis and management of laryngeal dysplasia[J]. Clin Otolaryngol, 2010, 35(3):170-176.
[6] 杨庆文, 徐文, 叶京英, 等. 声带白斑124例临床及病理分析[J]. 听力学及言语疾病杂志, 2011, 19(5):425-427. YANG Qingwen, XU Wen, YE Jingying, et al. Clinical and pathological analysis for 124 cases of vocal cord leukoplakia[J]. J Audiol Speech Pathol, 2011, 19(5):425-427.
[7] Ma L J, Wang J, Xiao Y, et al. Clinical classification and treatment of leukokeratosis of the vocal cords[J]. Chin Med J(Engl), 2013, 126(18):3523-3527.
[8] Lee D H, Yoon T M, Lee J K, et al. Predictive factors of recurrence and malignant transformation in vocal cord leukoplakia[J]. Eur Arch Otorhinolaryngol, 2015, 272(7):1719-1724.
[9] Pantel M, Guntinas-Lichius O. Laryngeal carcinoma: epidemiology, risk factors and survival[J]. HNO, 2012, 60(1):32-40.
[10] 朱虹, 徐文, 李赟, 等. 声带白斑临床病理特征与咽喉反流的初步观察[J]. 中华耳鼻咽喉头颈外科杂志, 2014, 49(5):368-373. ZHU Hong, XU Wen, LI Yun, et al. Observation of clinicopathological characteristics of vocal fold leukoplakia and laryngopharyngeal reflux[J]. Chin J Otorhinolarynol Head Neck Surg, 2014, 49(5):368-373.
[11] Isenberg J S, Crozier D L, Dailey S H. Institutional and comprehensive review of laryngeal leukoplakia[J]. Ann Otol Rhinol Laryngol, 2008, 117(1):74-79.
[12] Nina G, Leslie M, Bostjan L, et al. Current review on squamous intraepithelial lesions of the larynx[J]. Histopathology, 2009, 54(6):639-656.
[13] Djukic V, Milovanovic J, Jotic A D, et al. Stroboscopy in detection of laryngeal dysplasia effectiveness and limitations[J]. J Voice, 2014, 28(2):262.e13-262.e21.
[14] 张革化, 黎景佳. 自身荧光内镜在喉癌早期诊断中的应用[J]. 中国医学文摘(耳鼻咽喉科学), 2011, 26(4):205-206. ZHANG Gehua, LI Jingjia. Application of autofluorescence endoscopy in the early diagnosis of laryngeal carcinoma[J]. Chin ENT News Rev, 2011, 26(4):205-206.
[15] 于红, 高圣锐, 孙志, 等. 内镜窄带成像技术在诊断早期喉癌及其癌前病变中的作用研究[J]. 中国实验诊断学, 2015(9):1487-1490. YU Hong, GAO Shengrui, SUN Zhi, et al.The value of narrow band imaging in the diagnosis of early laryngeal cancer and the precancerous lesion[J]. Chin J Lab Diag, 2015(9):1487-1490.
[16] 朱海, 张展. 光学相干断层扫描技术在肿瘤应用的新进展[J]. 世界最新医学信息文摘(连续型电子期刊), 2015, 36:20-21. ZHU Hai, ZHANG Zhan. New advances in the application of optical coherence tomography in tumor[J]. World Latest Med Infor(Continuous Electr J), 2015, 36:20-21.
[17] FerlitoA, Devaney K O, Woolgar J A, et al. Squamous epithelial changes of the larynx: diagnosis and therapy[J]. Head Neck, 2012, 34(12):1810-1816.
[18] 徐文. 声带白斑的诊断与治疗[J]. 中华耳鼻咽喉头颈外科杂志, 2015, 50(12):1049-1052. XU Wen. The diagnosis and treatment of vocal cord leukoplakia[J]. Chin J Otorhinolarynol Head Neck Surg, 2015, 50(12):1049-1052.
[19] Zhang Y, Liang G, Sun N, et al. Comparison of CO2 laser and conventional laryngomicrosurgery treatments of polyp and leukoplakia of the vocal fold[J]. Int J Clin Exp Med, 2015, 8(10):18265-18274.
[20] 古庆家, 李静娴, 冯勇, 等. CO2激光喉显微手术治疗声带白斑疗效观察[J]. 实用医院临床杂志, 2013, 10(4):144-146. GU Qingjia, LI Jingxian, FENG Yong, et al. Efficacy of CO2 laser treatment of vocal cord leukoplakia under phonomicrosurgery[J]. Prac J Clin Med, 2013, 10(4):144-146.
[1] WANG Chunyu, ZHANG Fen, WANG Beibei, LI Yuyue, WANG Xiaoyu, LI Zhiyun, ZHANG Qingquan. Clinical diagnosis and treatment of 32 cases of vocal cord leukoplakia [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 114-116.
Full text



[2] SHI Chun-sheng1, GE Chang-yi1, ZHANG Qing-quan2, SUN Yan2. Clinical analysis of palatine tumor in 61cases[J]. J Otolaryngol Ophthalmol Shandong Univ, 2013, 27(2): 46 -48 .