Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (2): 61-66.doi: 10.6040/j.issn.1673-3770.1.2020.003

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Comparison of corneal epithelial remodeling after FS-LASIK and SMILE treatment for myopia and astigmatism

TAO Ye1, ZHOU Yuehua1,2, LI Fusheng1, WANG Shen1, YIN Hongzhi1, QI Si1, YANG Haihong1, SHAN Tianfeng1,   

  1. WANG Fang11. Beijing Vision Optometry, Beijing 100191, China;
    2. College of Ophthalmology, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China
  • Published:2020-04-07

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Abstract: Objective To compare the characteristics of corneal epithelial remodeling after FS-LASIK and SMILE. Methods There were 33 males(65 eyes)and 27 females(54 eyes)with an average age of 26±6.5years. The mean spherical equivalent was -5.25±2 D. Patients were divided into two groups: the FS-LASIK group(29 patients, 58 eyes)or SMILE group(31 patients, 61 eyes). The RTvue-OCT system was used to measure the epithelium thickness within 0-2 mm and 2-5 mm from the central cornea of patients before and 1, 3, and 6 months after surgery. Results One month after surgery, however, there was a statistical difference between the average corneal epithelium thickness within 2 mm and 2-5 mm from the cornea in the FS-LASIK group (P=0.036). In the superior, nasal superior, temporal superior region, the thickness of the corneal epithelium within 2-5 mm increased less than the inferior, nasal inferior, and temporal inferior regions. These differences were statistically significant (P=0.042, P=0.031, P=0.049, respectively). There was a statistically significant difference between the average corneal epithelium thickness within 2 mm and 2-5 mm of the cornea in the SMILE group at 6 months after operation (P=0.047). In the range of 2-5 mm, the corneal epithelium thickness increased less in the superior, nasal superior, temporal superior regions than the thickness in the inferior, nasal inferior, and temporal inferior regions. These differences were statistically significant (P=0.012, P=0.035, P=0.009, respectively). Compared with the nasal and temporal sides, the thickness of the superior part was less, and the difference was statistically significant (P=0.045, P=0.017, respectively). For the FS-LASIK group, the corneal epithelium thickened from 1 to 6 months after surgery. It gradually decreased within 2 mm, and this difference was statistically significant (P=0.035). During this time period, the corneal epithelial thickness of the FS-LASIK group and the SMILE group was statistically significant at each position within a range of 0-5 mm (P<0.05). Conclusion Corneal epithelium thickening is more pronounced in FS-LASIK than in SMILE post-operation. The corneal epithelium thickening in FS-LASIK changes more obviously in the central area of the corneal resection. The corneal epithelium thickening in SMILE changes more obviously in the peripheral area of the corneal resection. Over time, the localized thickening of the corneal epithelium, which is located opposite to the incision location, continued after both procedures.

Key words: Femtosecond laser in situ keratomileusis, Small incision lenticular extraction, Corneal epithelium remodeling, Optical coherence tomography

CLC Number: 

  • R777
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