ISSN 1673-3770 CN 37-1437/R
Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (3): 32-39.doi: 10.6040/j.issn.1673-3770.1.2020.028
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WU Xinxin1, LI Jingjing1,2, MAO Ning3,4, ZHENG Guibin1,5, ZHENG Haitao5, CUI Jingjing6, JIA Chuanliang1, CHU Tongpeng4, MOU Yakui1,7, SONG Xicheng1,4,7
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| [1] | MA Jingyuan, WU Tianyi, SUN Zhanwei, WANG Weiwei, LI Shichao, WANG Guangke. Correlation between sinonasal inverted papilloma and peripheral inflammatory blood markers [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 35-39. |
| [2] | The objective of this study was to analyze the effects and possible regulatory mechanisms that Notch receptors could have on cisplatin resistance, observed in nasopharyngeal carcinoma. MethodsWestern blot analysis was used for the detection of Notch receptor expression in nasopharyngeal carcinoma cells and cisplatin-resistant nasopharyngeal carcinoma cells(5-8F, 5-8F/CDDP). Flow cytometry was used to investigate how the combined treatment with 10 μM CDDP and different concentrations of γ-secretase inhibitor(DAPT)could affect apoptosis in 5-8F/CDDP cells. Flow cytometry was also used for the detection of cell cycle stages in DAPT-treated 5-8F / CDDP cells. Finally, western blotting was also used for the detection of drug resistance-related protein expression. All experiments were followed by statistical data analysis. ResultsWe observed significantly higher Notch1 and Notch4 receptor expression in 5-8F/CDDP cells than in 5-8F cells(P=0.003, P=0.004). Furthermore, we described that Notch signaling was inhibited by DAPT in 5-8F/CDDP cells, followed by a significant increase in the apoptosis rate and decrease in cell proliferation, induced by cisplatin in a dose-dependent manner(P<0.05). Moreover, after inhibiting the Notch signaling pathway in 5-8F/CDDP cells, DAPT treatment significantly decreased the expression of Cyclin E and CDK-2, proteins involved in cell cycle regulation, and contributed to blocking the cells in the G1/S phase(P<0.05). At the same time, the expression levels of both the EMT-related protein Slug and the DNA excision repair protein ERCC1 significantly decreased, while that of E-Cadherin was up-regulated. ConclusionUp-regulated expression of Notch1 and Notch4 receptors is associated with cisplatin resistance in nasopharyngeal carcinoma cells. The inactivation of the Notch signaling pathway might thus have the potential to enhance the efficiency of cisplatin chemotherapy in drug-resistant nasopharyngeal carcinoma cells by inhibiting EMT rather than blocking the G1/S cell cycle phase.. Cisplatin resistance in nasopharyngeal carcinoma cells is affected by Notch receptors through the regulation of epithelial-mesenchymal transition rather than cell cycle controlHAN Jibo, ZOU You, YANG Rui, TAO Zezhang Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, ChinaAbstract:Objective〓 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 105-110. |
| [3] | This study aimed to describe the clinical features of 74 patients with cleft palate cysts and fistulas and analyze the diagnosis and treatment methods. MethodsBetween January 2010 and September 2019, the clinical data of 74 patients with branchial cleft cysts and fistulas were retrospectively reviewed and analyzed with related literature in our department. ResultsOf the 74 patients, 50 patients were diagnosed with second branchial cleft anomalies, 13 patients had first branchial cleft lesions, 10 patients had third branchial cleft lesions, and one patient had a fourth branchial cleft lesion. All patients received surgical treatment. After the exclusion of 3 patients who were lost to follow-up, 67 patients were successfully treated, 3 patients reported relapse, and 1 had permanent facial paralysis. ConclusionsThe clinical manifestations of congenital cleft palate cysts and fistulas are diverse, and the differential diagnosis is complicated. It is essential to perform a detailed physical examination and preoperative evaluation to make an accurate diagnosis. The approach for management is individualized, and surgical rehabilitation is the preferred treatment.. Clinical analysis of 74 cases of branchial cleft cysts and fistulasWANG Yingying, ZHANG Liqing, ZHOU Han, DONG Shikun, CHEN Haibing, CHEN Xi, DONG Weida Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, ChinaAbstract:Objective〓 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 111-116. |
| [4] | ObjectiveThe aim of this study was to provide new perspectives and targets for the treatment of HNSCC by screening differentially expressed genes during cetuximab treatment of head and neck squamous cell carcinoma(HNSCC)using bioinformatics. MethodsThe chip dataset, GSE109756, was downloaded from the GEO database, and the online analysis tool, GEO2R, was used to screen differentially expressed genes in head and neck squamous cell carcinoma tissues treated with and without cetuximab. The DAVID 6.8 and STRING online software were used to analyze the function of the differentially expressed genes, their pathway enrichment, and their protein interactions. Cytoscape was used to visualize and analyze the protein interactions. The online analysis tool, X2K, was used to find the transcription factors, the kinases of differentially expressed genes, and their mutual regulatory relationship with the targeted genes. ResultsNinety-one differentially expressed genes, including 50 up-regulated and 41 down-regulated genes(P<0.05; | logFC | > 1), were found in head and neck squamous cell carcinoma tissues treated with and without cetuximab. The GO and KEGG pathway analyses suggested that these differentially expressed genes were mainly enriched with immunomodulation, extracellular matrix, and other processes. Through the construction of a protein-protein interaction network, we screened CD163, VSIG4, and 3 other core differentially expressed genes(P<0.05), which were up-regulated after cetuximab treatment. In addition, our analysis shows that transcription factors, including SUZ12, TP63, and ESR1, played a key role in cetuximab treatment(P<0.05)and MAPK14, CDK1, and MAPK1 were the most important kinases during the process(P<0.05). ConclusionCD163, VSIG4, and the aforementioned transcription factors and protein kinases may be involved in the biological processes that underlie cetuximab treatment of HNSCC. This study provides new perspectives to facilitate further understanding of the biological mechanism that underlies cetuximab treatment of HNSCC and the exploration of the effectiveness of HNSCC treatment.. Analysis of differentially expressed genes during cetuximab treatment of head and neck squamous cell carcinoma using bioinformaticsYU Kena1, SUN Kaiyue2, ZHANG Jie1, JIN Peng1 1. Department of Otorhinolaryngology & Head and Neck Surgery, The Second Hospital of Shandong University, Jinan 250033, Shandong, China; 2. Shandong Provincial Otorhinolaryngology Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250022, Shandong, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 117-124. |
| [5] | DENG Di, LIU Jun, LI Linke, WANG Ji, LIU Jifeng, LV Dan, WANG Haiyang, GAN Weigang, WANG Jun, LI Bo, CHEN Fei. Two-stage reconstructive strategy using a flap for non-circumferential tracheal defects [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(3): 52-57. |
| [6] | WANG Maolin, LI Julan, XIAN Kunlun. Efficacy of different transplantation schemes for parathyroid gland resection in patients with secondary hyperparathyroidism [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(3): 114-119. |
| [7] | Zhili WANG,Zhe CHEN,Fangyu LIN,Yongchuan CHAI,Zhaoyan WANG. Facial nerve reconstruction in the parotid area under a variety of circumstances [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(1): 15-19. |
| [8] | Jian FENG,Han ZHOU,Shenghua SONG,Qing ZHAO,Jiacheng ZHANG,Yaqin LIU,Yujie SHEN,Weida DONG. Clinical analysis of 15 cases of adenoid cystic carcinoma in the paranasal sinuses and nasal cavity [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 87-91. |
| [9] | Lin LI,Heng ZHANG,Yufei XIAN,Xiaoli SHENG. Expression and biological function of long chain non-coding cytoskeleton regulator RNA in nasopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(5): 69-72. |
| [10] | LUO Tongyong, YANG Huaqing, YUE Shengqing, JIA Quanfan, YUAN Long. Panitan single resistance and taxol as the first-line treatment of recurrent or metastatic head and neck cancer: a phase Ⅱ study [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 71-75. |
| [11] | DING Jie, SUN Yan. Survey of overall sleep quality in 142 patients with laryngectomy [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 76-81. |
| [12] | HUANG He, OUYANG Hui. Risk factors and prognosis of esophageal cancer with hypopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 82-86. |
| [13] | ZHANG Xiaoping, YANG Dengquan, WANG Shaoxin, HUANG Xiaoming. Effects of continuous out-of-hospital administration on the quality of life in patients with laryngeal cancer [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 169-174. |
| [14] | Ming LIU. Transoral laser microsurgery for early glottic neoplasms [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 6-9. |
| [15] | Xiaohan SUN,Na LI. Application of laryngeal retention strategy in the treatment of laryngeal cancer - introduction to the clinical practice guide of the American Society of Clinical Oncology (2017) [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2019, 33(4): 40-42. |
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