Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (4): 60-63.doi: 10.6040/j.issn.1673-3770.1.2020.056

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Analysis of choroidal thickness in patients with ocular ischemic syndromeFU Qiang, WANG Hongxing Department of Ophthalmology, Beijing Chuiyangliu Hospital, Beijing 100022, ChinaAbstract: Objective〓

Spectral-domain optical coherence tomography(SD-OCT)was used to measure and observe the characteristics of the subfoveal choroidal thickness(SFCT)in patients with ocular ischemic syndrome(OIS)as well as explore the indicators for early evaluation of OIS. MethodsThis was a retrospective case-control study. Forty-eight patients(48 eyes)were included between January 2017 and January 2020. The patients were divided into two groups: the OIS and the control groups, with each consisting of 24 patients(24 eyes). Their basic information, including age, gender, body mass index(BMI), and the history of diabetes, hypertension, and hyperlipidemia, was collected. SFCT was measured using SD-OCT in EDI mode. The basic data and SFCTs of the two groups were compared. ResultsThere were no significant differences between the ages, gender, BMIs, and the prevalence of diabetes, hypertension, and hyperlipidemia of the two groups(all P>0.05). The mean SFCT of the OIS group was 204.83±27.34 μm, and that of the control group was 226.58±33.49 μm. The differences between the two groups were statistically significant(t=2.464, P=0.018). ConclusionsSFCT was thinner in patients with OIS. SFCT can be used as an indicator for early assessment of OIS.   

  1. Key words:Ocular ischemic syndrome(OIS);
    Choroidal thickness;
    Spectral-domain optical coherence tomography(SD-OCT)眼缺血综合征［1］(ocular ischemic syndrome, OIS)由慢性严重的颈动脉阻塞或狭窄所致脑和眼的供血不足而产生一系列颅内缺血和眼部缺血的临床综合征。OIS可造成脑卒中［2］、心肌梗死［3］等致命性疾病的发生, 也可引起永久性视力损伤［4］。有研究表明［5］眼部缺血会先于脑血管病的发生。因此探索OIS患者眼部的评估指标对于预警致命性的心脑血管事件的发生有至关重要的意义。我们应用频域光学相干断层扫描仪(spectral-domain optical coherence tomography, SD-OCT)的增强深度成像(enhanced depth imaging, EDI)模式, 测量黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness, SFCT), 旨在观察OIS患者SFCT的特征, 进一步探索早期评估OIS的指标。
  • Received:2019-05-29 Online:2020-07-20 Published:2020-08-28

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Abstract: Objective Spectral-domain optical coherence tomography(SD-OCT)was used to measure and observe the characteristics of the subfoveal choroidal thickness(SFCT)in patients with ocular ischemic syndrome(OIS)as well as explore the indicators for early evaluation of OIS. Methods This was a retrospective case-control study. Forty-eight patients(48 eyes)were included between January 2017 and January 2020. The patients were divided into two groups: the OIS and the control groups, with each consisting of 24 patients(24 eyes). Their basic information, including age, gender, body mass index(BMI), and the history of diabetes, hypertension, and hyperlipidemia, was collected. SFCT was measured using SD-OCT in EDI mode. The basic data and SFCTs of the two groups were compared. Results There were no significant differences between the ages, gender, BMIs, and the prevalence of diabetes, hypertension, and hyperlipidemia of the two groups(all P>0.05). The mean SFCT of the OIS group was 204.83±27.34 μm, and that of the control group was 226.58±33.49 μm. The differences between the two groups were statistically significant(t=2.464, P=0.018). Conclusions SFCT was thinner in patients with OIS. SFCT can be used as an indicator for early assessment of OIS.

Key words: Ocular ischemic syndrome(OIS), Choroidal thickness, Spectral-domain optical coherence tomography(SD-OCT)

CLC Number: 

  • R773.1
[1] Lauria AL, Koelling EE, Houghtaling PM, et al. Carotid Endarterectomy for Ocular Ischemic Syndrome: A Case Report and Review of the Literature[J]. Ann Vasc Surg, 2020. doi: 10.1016/j.avsg.2020.03.005.
[2] Avery MB, Magal I, Kherani A, et al. Risk of Stroke in Patients With Ocular Arterial Occlusive Disorders: A Retrospective Canadian Study[J]. J Am Heart Assoc, 2019, 3(8): e010509. doi: 10.1161/JAHA.118.010509.
[3] Hayreh SSZimmerman MB. Ocular Arterial Occlusive Disorders and Carotid Artery Disease[J]. Ophthalmol Retina, 2017, 1(1): 12-18. doi: 10.1016/j.oret.2016.08.003.
[4] Makhkamova Dcapital Ka C. [Etiopathogenesis of ocular ischemic syndrome] [J]. Vestn Oftalmol, 2017, 2(133):120-124. doi: 10.17116/oftalma20171332120-124.
[5] Volkers EJ, Donders RC, Koudstaal PJ, et al. Transient monocular blindness and the risk of vascular complications according to subtype: a prospective cohort study[J]. J Neurol, 2016, 9(263): 1771-1777. doi: 10.1007/s00415-016-8189-x.
[6] Luo J, Yan Z, Jia Y, et al. Clinical Analysis of 42 Cases of Ocular Ischemic Syndrome[J]. J Ophthalmol, 2018,(2018):2606147. doi: 10.1155/2018/2606147.
[7] Hung JHChang YS. Ocular ischemic syndrome[J]. CMAJ, 2017, 23(189): E804. doi: 10.1503/cmaj.160459.
[8] Wang H, Wang YLi H. Multimodality Imaging Assessment of Ocular Ischemic Syndrome[J]. J Ophthalmol, 2017,(2017): 4169135. doi: 10.1155/2017/4169135.
[9] Chen Q, Niu S, Fang W, et al. Automated choroid segmentation of three-dimensional SD-OCT images by Incorporating EDI-OCT images[J]. Comput Methods Programs Biomed, 2018(158): 161-171. doi: 10.1016/j.cmpb.2017.11.002.
[10] Formisano M, Abdolrahimzadeh B, Mollo R, et al. Bilateral diffuse choroidal hemangioma in Sturge Weber syndrome: A case report highlighting the role of multimodal imaging and a brief review of the literature[J]. J Curr Ophthalmol, 2019, 2(31): 242-249. doi: 10.1016/j.joco.2018.10.001.
[11] Ayyildiz O, Kucukevcilioglu M, Ozge G, et al. Comparison of peripapillary choroidal thickness measurements via spectral domain optical coherence tomography with and without enhanced depth imaging[J]. Postgrad Med, 2016, 4(128): 439-443. doi: 10.1080/00325481.2016.1171119.
[12] Gupta C, Tan R, Mishra C, et al. Choroidal structural analysis in eyes with diabetic retinopathy and diabetic macular edema-A novel OCT based imaging biomarker[J]. PLoS One, 2018, 12(13): e0207435. doi: 10.1371/journal.pone.0207435.
[13] 晏红改, 李骏, 杨柳. 相干光断层成像术在葡萄膜炎患者中的应用[J]. 中华眼科杂志, 2015,51(10):790-794. doi:10.3760/cma.j.issn.0412-4081. 2015.10.020. YAN Honggai, LI Jun, YANG Liu. The application of optical coherence tomography in uveitis patients[J]. Chinese Journal of Ophthalmology, 2015, 51(10):790-794. doi:10.3760/cma.j.issn.0412-4081.2015.10.020.
[14] Sanabria Sanchinel AA, Esteban Floria MO, Tejero Juste C, et al. [Ocular ischemic syndrome: clinical manifestations, diagnosis and evolution after treatment.] [J]. Rev Fac Cien Med Univ Nac Cordoba, 2019, 1(76): 63-67. doi:10.31053/1853.0605.v76.n1.21271.
[15] Calzetti G, Fondi K, Bata AM, et al. Assessment of choroidal blood flow using laser speckle flowgraphy[J]. Br J Ophthalmol, 2018, 12(102): 1679-1683. doi: 10.1136/bjophthalmol-2017-311750.
[16] Lin X, Song J, Gao W, et al. Acute ocular ischemic syndrome[J]. QJM, 2017, 12(110): 831-832. doi: 10.1093/qjmed/hcx160.
[17] Maruko I, Kawano T, Arakawa H, et al. Visualizing large choroidal blood flow by subtraction of the choriocapillaris projection artifacts in swept source optical coherence tomography angiography in normal eyes[J]. Sci Rep, 2018, 1(8): 15694. doi: 10.1038/s41598-018-34102-6.
[18] Rebhun CB, Moult EM, Ploner SB, et al. Analyzing Relative Blood Flow Speeds in Choroidal Neovascularization Using Variable Interscan Time Analysis OCT Angiography[J]. Ophthalmol Retina, 2018, 4(2): 306-319. doi: 10.1016/j.oret.2017.08.013.
[19] Kang HM, Choi JH, Koh HJ, et al. Significant changes of the choroid in patients with ocular ischemic syndrome and symptomatic carotid artery stenosis[J]. PLoS One, 2019, 10(14): e0224210. doi: 10.1371/journal.pone.0224210.
[20] Wang H, Wang YLLi HY. Subfoveal choroidal thickness and volume in severe internal carotid artery stenosis patients[J]. Int J Ophthalmol, 2017, 12(10): 1870-1876. doi: 10.18240/ijo.2017.12.13.
[1] ObjectiveTo discuss the causes and appropriate treatment for iris neovascularization following the analysis of 25 cases(28 eyes). MethodsIt was a retrospective case series study involving 25 patients(28 eyes)with iris neovascularization diagnosed between September 2014 and July 2016. All the patients underwent ophthalmic examination, and all the examination findings and treatments were recorded. The causes, correlative factors, and treatment outcomes of iris neovascularization were analyzed. ResultsOf the patients, 17(20 eyes, 71.4%)had retinal ischemic signs, including vitreous hemorrhage and retinal vascularization on fundus fluorescein angiography; 8(8 eyes, 28.6%)did not have retinal ischemic signs. After 3 months of treatment, retinal vascularization resolved in all the cases, and iris neovascularization resolved completely in 20 patients(23 eyes, 82.1%), iris neovascularization was still found in 5 patients(5 eyes, 17.9%). ConclusionsAnterior segment ischemia may also lead to iris vascularization, although retinal ischemia was the main cause. Additionally, iris neovascularization may not always resolve with treatment for retinal ischemia. Finally, anti-VEGF drug injection was an effective treatment for iris neovascularization.. Case analysis of 25 cases of iris neovascularizationLI Xuan1,2, HUANG Yingxiang2 1. Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China; 2. Department of Fundus Disease and Eye Trauma, Eye Hospital China Academy of Chinese Medicine Sciences, Beijing 100040, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 41-47.
[2] ZHANG Ning, TIAN Jie, ZHAO Jun. A simple repair of partical iridoialysis in 16 cases [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(6): 547-548.
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