Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (4): 64-68.doi: 10.6040/j.issn.1673-3770.1.2020.052

Previous Articles     Next Articles

Association between the classification of blood pressure and retinal vessel diameter measured by SD-OCTFENG Xue1, WANG Haiwei2, LI Wensi1, YANG Xintong1, SUN Cun1, ZHAO Yuan1, ZHAO Pengbo1, ZHANG Jianqiang1 1. Department of Ophthalmology, Beijing Moslem People's Hospital, Beijing 100054, China; 2. Department of Ophthalmology, Fuxing Hospital, Capital Medical University, Beijing 100038, ChinaAbstract:

ObjectiveTo analyze the association between the classification of blood pressure and retinal vessel diameter measured by spectral-domain optical coherence tomography(SD-OCT). MethodsThis was a cross-sectional study that included 103 patients(103 eyes)with hypertension. Based on the classification of hypertension, the subjects were divided into three groups: the isolated systolic hypertension(ISH)(34 eyes), isolated diastolic hypertension(IDH)(34 eyes), and systolic combined with diastolic hypertension(SDH)(35 eyes)groups. Retinal vessel diameters were measured by SD-OCT. The differences among the central retinal arteriolar equivalents(CRAEs), the central retinal venular equivalents(CRVEs), and the artery-to-vein ratios(AVRs)of the three groups were analyzed. Multivariate logistic regression was performed to evaluate the association between blood pressure and AVR. ResultsThere were significant differences among the CRAEs and AVRs of the three groups(F=4.543, 4.308; P=0.013, 0.016). The CRAE and AVR of the SDH group were the lowest; those of the IDH group were the highest. There were no significant differences among the CRVEs of the three groups(F=0.417, P=0.660). After correction for risk factors, such as gender and age, multivariate logistic regression showed that patients with high systolic blood pressure were more likely to have AVRs of < 0.7 (OR=1.080, P=0.015). ConclusionsAmong the three types of hypertension, SDH was associated with the lowest CRAE and AVR. High systolic pressure is a risk factor for AVRs of < 0.7.   

  1. Key words:Spectral domain;
    Optical coherence tomography;
    Hypertension;
    Classification;
    Retina;
    vascular diameter全球高血压的患病率呈升高趋势, 预计2025年将累及全世界近1/3的人口［1］。高血压可引起眼［2］、脑［3］、肾［4］等多个靶器官损害。高血压早期, 视网膜动脉痉挛变细［5］, 随着高血压的进展, 可出现高血压性小动脉硬化改变, 即视网膜动脉管腔狭窄等病理变化［6］。关于高血压的不同类型对视网膜血管管径影响的相关研究报道较少。我们应用频域光学相干断层成像(Spectral domain optical coherence tomography, SD-OCT)对以下三种类型的高血压即单纯收缩期高血压(isolated systolic hypertension, ISH)、单纯舒张期高血压(isolated diastolic hypertension, IDH)、收缩期和舒张期联合性高血压(systolic combined with diastolic hypertension, SDH)患者的视网膜血管管径进行测量, 旨在探讨视网膜血管管径在不同高血压类型方面的差异。
  • Received:2020-05-22 Online:2020-07-20 Published:2020-08-28

PDF (PC)

783

Abstract: Objective To analyze the association between the classification of blood pressure and retinal vessel diameter measured by spectral-domain optical coherence tomography(SD-OCT). Methods This was a cross-sectional study that included 103 patients(103 eyes)with hypertension. Based on the classification of hypertension, the subjects were divided into three groups: the isolated systolic hypertension(ISH)(34 eyes), isolated diastolic hypertension(IDH)(34 eyes), and systolic combined with diastolic hypertension(SDH)(35 eyes)groups. Retinal vessel diameters were measured by SD-OCT. The differences among the central retinal arteriolar equivalents(CRAEs), the central retinal venular equivalents(CRVEs), and the artery-to-vein ratios(AVRs)of the three groups were analyzed. Multivariate logistic regression was performed to evaluate the association between blood pressure and AVR. Results There were significant differences among the CRAEs and AVRs of the three groups(F=4.543, 4.308; P=0.013, 0.016). The CRAE and AVR of the SDH group were the lowest; those of the IDH group were the highest. There were no significant differences among the CRVEs of the three groups(F=0.417, P=0.660). After correction for risk factors, such as gender and age, multivariate logistic regression showed that patients with high systolic blood pressure were more likely to have AVRs of < 0.7 (OR=1.080, P=0.015). Conclusions Among the three types of hypertension, SDH was associated with the lowest CRAE and AVR. High systolic pressure is a risk factor for AVRs of < 0.7.

Key words: Spectral domain, Optical coherence tomography, Hypertension, Classification, Retina, vascular diameter

CLC Number: 

  • R774.1
[1] Haeusler KG, Huttner HB, Kuramatsu JB. Comment on 2018 ESC/ESH Guidelines for the management of arterial hypertension[J]. Eur Heart J, 2019, 40(25): 2092. doi:10.1093/eurheartj/ehz126.
[2] Fraser-Bell S, Symes R, Vaze A. Hypertensive eye disease: a review[J]. Clin Experiment Ophthalmol, 2017, 45(1): 45-53. doi:10.1111/ceo.12905.
[3] Moroni F, Ammirati E, Magnoni M, et al. Carotid atherosclerosis, silent ischemic brain damage and brain atrophy: a systematic review and meta-analysis[J]. Int J Cardiol, 2016, 223: 681-687. doi:10.1016/j.ijcard.2016.08.234.
[4] Sun D, Wang JJ, Wang W, et al. Human podocyte injury in the early course of hypertensive renal injury[J]. World J Clin Cases, 2019, 7(22): 3698-3710. doi:10.12998/wjcc.v7.i22.3698.
[5] Yıldırım T, Özkan S, Yılmaz ÖÇ, et al. Increased rate of any retinopathy risk in patients with masked hypertension[J]. Clin Exp Hypertens, 2020, 42(6): 479-482. doi:10.1080/10641963.2019.1705320.
[6] Ali F, Tacey M, Lykopandis N, et al. Microvascular narrowing and BP monitoring: a single centre observational study[J]. PLoS One, 2019, 14(3): e0210625. doi:10.1371/journal.pone.0210625.
[7] Omboni S, Posokhov I, Parati G, et al. Variable association of 24-h peripheral and central hemodynamics and stiffness with hypertension-mediated organ damage: the VASOTENS Registry[J]. J Hypertens, 2020, 38(4): 701-715. doi:10.1097/HJH.0000000000002312.
[8] Harjasouliha A, Raiji V, Garcia Gonzalez JM. Review of hypertensive retinopathy[J]. Dis Mon, 2017, 63(3): 63-69. doi:10.1016/j.disamonth.2016.10.002.
[9] 陈璇,韩莉,范传峰,等. 高血压视网膜病变患者血浆内皮素-1的表达及意义[J]. 山东大学耳鼻喉眼学报,2016,30(6):78-80. doi: 10.6040/j.issn.1673-3770.0.2016.066. CHEN Xuan,HAN Li, FAN Chuanfeng, et al. Expression of endothelin-1 in plasma of patients with hypertensive retinopathy in essential hypertension[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2016,30(6):78-80. doi: 10.6040/j.issn.1673-3770.0.2016.066.
[10] Dumitrescu AG, Voinea L, Badarau IA, et al. Update on retinal vascular caliber[J]. Rom J Ophthalmol, 2017, 61(3): 171-180. doi:10.22336/rjo.2017.32.
[11] Heitmar R, Kalitzeos AA, Patel SR, et al. Comparison of subjective and objective methods to determine the retinal arterio-venous ratio using fundus photography[J]. J Optom, 2015, 8(4): 252-257. doi:10.1016/j.optom.2014.07.002.
[12] Wei FF, Thijs L, Yu CG, et al. Retinal microvasculature in relation to central hemodynamics in a Flemish population[J]. Hypertension, 2019, 74(3): 606-613. doi:10.1161/HYPERTENSIONAHA.119.13255.
[13] Schuster AK, Fischer JE, Vossmerbaeumer C, et al. Optical coherence tomography-based retinal vessel analysis for the evaluation of hypertensive vasculopathy[J]. Acta Ophthalmol, 2015, 93(2): e148-e153. doi:10.1111/aos.12509.
[14] Rim TH, Choi YS, Kim SS, et al. Retinal vessel structure measurement using spectral-domain optical coherence tomography[J]. Eye(Lond), 2016, 30(1): 111-119. doi:10.1038/eye.2015.205.
[15] Ouyang YL, Shao Q, Scharf D, et al. Retinal vessel diameter measurements by spectral domain optical coherence tomography[J]. Graefes Arch Clin Exp Ophthalmol, 2015, 253(4): 499-509. doi:10.1007/s00417-014-2715-2.
[16] Yano Y, Neeland IJ, Ayers C, et al. Hemodynamic and mechanical properties of the proximal aorta in young and middle-aged adults with isolated systolic hypertension: the Dallas heart study[J]. Hypertension, 2017, 70(1): 158-165. doi:10.1161/HYPERTENSIONAHA.117.09279.
[17] Muiesan ML, Paini AN, Aggiusti C, et al. Hypertension and organ damage in women[J]. High Blood Press Cardiovasc Prev, 2018, 25(3): 245-252. doi:10.1007/s40292-018-0265-0.
[18] Rubio-Guerra A, Duran-Salgado M. Recommendations for the treatment of hypertension in elderly people[J]. Cardiovasc Hematol Agents Med Chem, 2015, 12(3): 146-151. doi:10.2174/1871525713666150310110357.
[19] Mittal C, Singh M, Bakhshi T, et al. Isolated diastolic hypertension and its risk factors in semi-rural population of South India[J]. Indian Heart J, 2019, 71(3): 272-276. doi:10.1016/j.ihj.2019.07.007.
[20] Aissopou EK, Papathanassiou M, Nasothimiou EG, et al. The Keith-Wagener-Barker and Mitchell-Wong grading systems for hypertensive retinopathy: association with target organ damage in individuals below 55 years[J]. J Hypertens, 2015, 33(11): 2303-2309. doi:10.1097/HJH.0000000000000702.
[21] Takayama K, Kaneko H, Ito Y, et al. Novel classification of early-stage systemic hypertensive changes in human Retina based on OCTA measurement of choriocapillaris[J]. Sci Rep, 2018, 8(1): 15163. doi:10.1038/s41598-018-33580-y.
[22] Duarte T, Gonçalves S, Brito R, et al. Relationship between nocturnal blood pressure profiles and the presence and severity of hypertensive retinopathy[J]. Rev Port Cardiol, 2018, 37(2): 169-173. doi:10.1016/j.repc.2017.06.009.
[1] ZHAO Juan, JIAO Wanzhen, ZHAO Bojun. Assessment of fundus microcirculation changes in diabetic retinopathy using UWFSS-OCTA [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 80-86.
[2] ZHANG Xin, LIU Yajie, LI Fei, HUANG Chunmei, ZHANG Huixin, ZHU Jiabin. Correlation between hemodynamic parameters of the ophthalmic artery and central retinal artery in patients with severe OSA with AHI and LSaQ2 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(2): 87-94.
[3] ZHU Mingqiong, LI Zheng, LIU Ru, TIAN Tao, PENG Jingli, LYU Qianyi, TAN Huaxia. The application of AI screening system based on OCT/OCTA in the evaluation of the effect of anti VEGF treatment in patients with diabetes macular edema [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 68-73.
[4] LI Shiqiang, MA Yan, WANG Jiawei. Advances in clinical applications of optical coherence tomography angiography in systemic diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 127-134.
[5] DING Shuliang, WANG Chaofan, LIU Jianliang. A case of intraocular fluid detection to guide precise treatment of acute retinal necrosis and review of the literature [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 114-117.
[6] WANG Huanxia, WANG Shuya, WANG Ying, SUN Xuan, HUANG Jie, WANG Xingrong. Risk factors for epiretinal membrane formation following pars plana vitrectomy for rhegmatogenous retinal detachment [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(4): 181-185.
[7] ZENG Qiying, ZHU Huaming, GUAN Jian, WU Hongmin, YE Haibo, YI Hongliang. Bipolar coagulation forceps applied in the treatment of 6 cases of shamblin type III carotid body tumors [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 70-76.
[8] LI Zhicheng, YAN Ya, DAI Liangping, YING Junjie, WANG Renzhong. Research progress of animal models of olfactory disorders [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 158-167.
[9] ZHANG Lu, WANG Yongjing, JIA Jun, ZHAO Jiannan, ZHAO Fang. Spectral domain optical coherence tomography imaging characteristics in patients with initial onset floaters [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 85-88.
[10] XIAO Zhe, ZHANG Shengjuan, ZHAO Ziqi, XING Chen, LI Chengquan, LIU Zhiqiang. Ultra Q:YAG laser treatment for macular retinal pre-retinal hemorrhage in 17 cases and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 130-135.
[11] XU Wanjing, SUN Yuhao, ZHAO Jun. Effects of antioxidant activity of curcumin in retinal degenerative diseases [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 146-151.
[12] YANG Songyue, ZHANG Meixia. Advances in single-cell RNA sequencing in the retina [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 162-170.
[13] HUANG Jiao, PENG Changfu. Progress in objective evaluation of thyroid-related eye disease activity [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 171-178.
[14] ZHANG Jinmu, GUO Bin, JIANG Wenjun, LIU Dongmei. Research progress on the role of M receptor signaling pathway in the occurrence and development of myopia [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 160-164.
[15] MA Jiling, WANG Xiaoming, LI Yan, MU Yanxiao, JIN Lin, KONG Hui, YANG Naifu, DANG Guangfu. Evaluation of three different aspheric intraocular lens tilts and decentrations in capsular bags after cataract surgery based on CASIA2 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 76-85.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd