Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2020, Vol. 34 ›› Issue (5): 152-156.doi: 10.6040/j.issn.1673-3770.0.2019.595

Previous Articles     Next Articles

Correlation between obstructive sleep apnea and tumors

  

  • Received:2019-11-30 Published:2020-11-17

Abstract: Obstructive sleep apnea(OSA)is a chronic disease that is prevalent worldwide. The morbidity of OSA has increased year by year. The primary characteristic of OSA is repeated upper airway collapse, which causes recurrent apnea, hypopnea, and frequent decline of the oxyhemoglobin saturation. This leads to sleep fragmentation and sleep structure disorder. Patients with OSA usually suffer from daytime sleepiness and inattention. Long-term sleep fragmentation and micro-arousal state are related to many chronic diseases, such as hypertension, myocardial infarction, Type 2 diabetes and Alzheimer's disease. Moreover, OSA is also closely related to tumors. With increases in the degree of OSA and hypoxemia, the incidence and mortality of related tumors have also gone up. Such tumors include lung, breast, nasopharyngeal, prostate and central nervous system cancers. To provide a reference for OSA and tumor-related research and clinical practice and develop ideas around further treatment research that could be conducted, this article reviews the profile of OSA and the statistical evidence, moreover, the molecular mechanism and treatment of OSA related to tumors will be discussed.

Key words: Obstructive sleep apnea, Hypopnea, Tumor, Correlation

CLC Number: 

  • R766.7
[1] Peltier LF. Obstructive apnea in artificially hyperventilated subjects during sleep[J]. Journal of Applied Physiology, 1953, 5(10): 614-618. doi:10.1152/jappl.1953.5.10.614.
[2] Sackner MA, Landa J, Forrest T, et al. Periodic sleep apnea: chronic sleep deprivation related to intermittent upper airway obstruction and central nervous system disturbance[J]. Chest, 1975, 67(2): 164-171. doi: 10.1378/chest.67.2.164.
[3] Senaratna CV, Perret JL, Lodge CJ, et al. Prevalence of obstructive sleep apnea in the general population: a systematic review[J]. Sleep Med Rev, 2017, 34: 70-81. doi:10.1016/j.smrv.2016.07.002.
[4] Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults[J]. Am J Epidemiol, 2013, 177(9): 1006-1014. doi:10.1093/aje/kws342.
[5] Fleming WE, Holty JC, Bogan RK, et al. Use of blood biomarkers to screen for obstructive sleep apnea[J]. Nat Sci Sleep, 2018, 10: 159-167. doi:10.2147/NSS.S164488.
[6] Cori JM, O'Donoghue FJ, Jordan AS. Sleeping tongue: current perspectives of genioglossus control in healthy individuals and patients with obstructive sleep apnea[J]. Nat Sci Sleep, 2018, 10: 169-179. doi:10.2147/NSS.S143296.
[7] 孔维佳, 周梁. 耳鼻咽喉头颈外科学[M]. 北京: 人民卫生出版社, 2015: 412-419.
[8] Durán-Cantolla J, Aizpuru F, Martínez-Null C, et al. Obstructive sleep apnea/hypopnea and systemic hypertension[J]. Sleep Med Rev, 2009, 13(5): 323-331. doi:10.1016/j.smrv.2008.11.001.
[9] Aronson D, Nakhleh M, Zeidan-Shwiri T, et al. Clinical implications of sleep disordered breathing in acute myocardial infarction[J]. PLoS One, 2014, 9(2): e88878. doi:10.1371/journal.pone.0088878.
[10] Hao NB, Lü MH, Fan YH, et al. Macrophages in tumor microenvironments and the progression of tumors[J]. Clin Dev Immunol, 2012, 2012: 1-11. doi:10.1155/2012/948098.
[11] Lim AS, Yu L, Kowgier M, et al. Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep[J]. JAMA Neurol, 2013, 70(12): 1544-1551. doi:10.1001/jamaneurol.2013.4215.
[12] Kang Y, Greaves B, Perry RR. Effect of acute and chronic intermittent hypoxia on DNA topoisomerase II alpha expression and mitomycin C-induced DNA damage and cytotoxicity in human colon cancer cells[J]. Biochem Pharmacol, 1996, 52(4): 669-676. doi:10.1016/0006-2952(96)00343-7.
[13] Chang WP, Liu ME, Chang WC, et al. Sleep apnea and the subsequent risk of breast cancer in women: a nationwide population-based cohort study[J]. Sleep Med, 2014, 15(9): 1016-1020. doi:10.1016/j.sleep.2014.05.026.
[14] Chen JC, Hwang JH. Sleep apnea increased incidence of primary central nervous system cancers: a nationwide cohort study[J]. Sleep Med, 2014, 15(7): 749-754. doi:10.1016/j.sleep.2013.11.782.
[15] Fang HF, Miao NF, Chen CD, et al. Risk of cancer in patients with insomnia, parasomnia, and obstructive sleep apnea: a nationwide nested case-control study[J]. J Cancer, 2015, 6(11): 1140-1147. doi:10.7150/jca.12490.
[16] Nieto FJ, Peppard PE, Young T, et al. Sleep-disordered breathing and cancer mortality: results from the Wisconsin Sleep Cohort Study[J]. Am J Respir Crit Care Med, 2012, 186(2): 190-194. doi:10.1164/rccm.201201-0130OC.
[17] Muz B, de la Puente P, Azab F, et al. The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy[J]. Hypoxia(Auckl), 2015, 3: 83-92. doi:10.2147/HP.S93413.
[18] Koh MY, Powis G. Passing the baton: the HIF switch[J]. Trends Biochem Sci, 2012, 37(9): 364-372. doi:10.1016/j.tibs.2012.06.004.
[19] Toffoli S, Michiels C. Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours[J]. FEBS J, 2008, 275(12): 2991-3002. doi:10.1111/j.1742-4658.2008.06454.x.
[20] Saxena K, Jolly MK. Acute vs. chronic vs. cyclic hypoxia: their differential dynamics, molecular mechanisms, and effects on tumor progression[J]. Biomolecules, 2019, 9(8): E339. doi:10.3390/biom9080339.
[21] Miao ZF, Zhao TT, Wang ZN, et al. Influence of different hypoxia models on metastatic potential of SGC-7901 gastric cancer cells[J]. Tumour Biol, 2014, 35(7): 6801-6808. doi:10.1007/s13277-014-1928-7.
[22] Celià-Terrassa T, Kang YB. Distinctive properties of metastasis-initiating cells[J]. Genes Dev, 2016, 30(8): 892-908. doi:10.1101/gad.277681.116.
[23] Hao NB, Lü MH, Fan YH, et al. Macrophages in tumor microenvironments and the progression of tumors[J]. Clin Dev Immunol, 2012, 2012: 1-11. doi:10.1155/2012/948098.
[24] 李兵, 王琼, 杨勐航. 探讨阻塞性睡眠呼吸暂停促进肿瘤发生发展的潜在机制[J]. 内科理论与实践, 2019, 14(1): 4-8. doi:10.16138/j.1673-6087.2019.01.002. LI Bing, WANG Qiong, YANG Menghang. The implication of obstructive sleep apnea in tumorigenesis[J]. Journal of Internal Medicine Concepts & Practice, 2019, 14(1): 4-8. doi:10.16138/j.1673-6087.2019.01.002.
[25] Marin JM, Agusti A, Villar I, et al. Association between treated and untreated obstructive sleep apnea and risk of hypertension[J]. JAMA, 2012, 307(20): 2169-2176. doi:10.1001/jama.2012.3418.
[26] Castronovo V, Scifo P, Castellano A, et al. White matter integrity in obstructive sleep apnea before and after treatment[J]. Sleep, 2014, 37(9): 1465-1475. doi:10.5665/sleep.3994.
[27] Choi JH, Cho SH, Kim SN, et al. Predicting outcomes after uvulopalatopharyngoplasty for adult obstructive sleep apnea: a meta-analysis[J]. Otolaryngol Head Neck Surg, 2016, 155(6): 904-913. doi:10.1177/0194599816661481.
[28] Ramar K, Dort LC, Katz SG, et al. Clinical practice guideline for the treatment of obstructive sleep apnea and snoring with oral appliance therapy: an update for 2015[J]. J Clin Sleep Med, 2015, 11(7): 773-827. doi:10.5664/jcsm.4858.
[29] Liao YF, Chiu YT, Lin CH, et al. Modified maxillomandibular advancement for obstructive sleep apnoea: towards a better outcome for Asians[J]. Int J Oral Maxillofac Surg, 2015, 44(2): 189-194. doi:10.1016/j.ijom.2014.09.013.
[30] Storto CJ, Garcez AS, Suzuki H, et al. Assessment of respiratory muscle strength and airflow before and after microimplant-assisted rapid palatal expansion[J]. Angle Orthod, 2019, 89(5): 713-720. doi:10.2319/070518-504.1.
[31] Chang ET, Kwon YD, Jung J, et al. Genial tubercle position and genioglossus advancement in obstructive sleep apnea(Osa)treatment: a systematic review[J]. Maxillofac Plast Reconstr Surg, 2019, 41(1): 34. doi:10.1186/s40902-019-0217-1.
[32] Strollo PJ Jr, Soose RJ, Maurer JT, et al. Upper-airway stimulation for obstructive sleep apnea[J]. N Engl J Med, 2014, 370(2): 139-149. doi:10.1056/NEJMoa1308659.
[33] 刘婷, 段爱雄, 韩光锋. 紫杉醇联合奈达铂诱导化疗后同步放化疗治疗局部晚期鼻咽癌52例[J]. 安徽医药, 2019, 23(4): 823-826. doi:10.3969/j.issn.1009-6469.2019.04.051. LIU Ting, DUAN Aixiong, HAN Guangfeng. Paclitaxel and nedaplatin neoadjuvant chemotherapy followed by concurrent chemoradiation for locoregionally advanced nasopharyngeal carcinoma: a clinical study of 52 cases[J]. Anhui Medical and Pharmaceutical Journal, 2019, 23(4): 823-826. doi:10.3969/j.issn.1009-6469.2019.04.051.
[34] Montoya A, Amaya CN, Belmont A, et al. Use of non-selective β-blockers is associated with decreased tumor proliferative indices in early stage breast cancer[J]. Oncotarget, 2017, 8(4): 6446-6460. doi:10.18632/oncotarget.14119.
[35] Guo XF, Liu Y, Kim JL, et al. Effect of cyclical intermittent hypoxia on Ad5CMVCre induced solitary lung cancer progression and spontaneous metastases in the KrasG12D+; p53fl/Fl; myristolated p110fl/fl Rosa-gfp mouse[J]. PLoS One, 2019, 14(2): e0212930. doi:10.1371/journal.pone.0212930.
[36] 黄坤林, 刘玉金. 肺癌介入治疗临床研究进展[J]. 介入放射学杂志, 2019, 28(10): 1005-1008. HUANG Kunlin, LIU Yujin. Recent progress in clinical application of interventional therapy for lung cancer[J]. Journal of Interventional Radiology, 2019, 28(10): 1005-1008.
[37] Sumanasuriya S, De Bono J. Treatment of advanced prostate cancer-A review of current therapies and future promise[J]. Cold Spring Harb Perspect Med, 2018, 8(6): a030635. doi:10.1101/cshperspect.a030635.
[38] 周利群. 前列腺癌的病因、诊断与治疗进展[J]. 继续医学教育, 2006, 20(8): 85-91. ZHOU Liqun. Etiopathogenisis, diagnosis and therapy progress of prostatic carcinoma[J]. Continuing Medical Education, 2006, 20(8): 85-91.
[39] Patchell RA, Tibbs PA, Regine WF, et al. Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial[J]. JAMA, 1998, 280(17): 1485-1489. doi:10.1001/jama.280.17.1485.
[1] ZHANG Keren, LEI Chunyan, ZHANG Meixia. Floppy eyelid syndrome associated with obstructive sleep apnea: a case report [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(5): 125-128.
[2] GONG Xiaoyang, LI Wang, CHEN Xi. Retrospective analysis of 67 cases of primary parapharyngeal space tumors [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 60-65.
[3] HAN Jibo, DONG Jie, MING Wei, WANG Yan, LUO Zhihong. The utility of different values of average oxygen saturation and minimum oxygen saturation between different sleep stages for predicting the uvulopalatopharyngoplastysurgery effect [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 73-78.
[4] ZHANG Lijun, XU Ran, LUO Jifang, LIU Guoqi, HE Qian, LI Wei, JIANG Zhenhua. Factors affecting flap neurosis and other postoperative flap-related complications after free-flap reconstruction of head and neck tumors [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 86-90.
[5] WANG MeiOverview,LI ZhihaiGuidance. Laryngeal cancer stem cells: potential therapeutic targets for overcoming multidrug resistance [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(4): 120-128.
[6] CHEN Jiahong, WANG Lin, JIANG Yan, YU Longgang, ZHANG Jisheng, ZHANG Zhiyong, KONG Jingwen. Primary extraskeletal Ewing sarcoma/peripheral primitive neuroectodermal tumor in the nasal cavity and paranasal sinus: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(3): 290-296.
[7] ZHAO Xiaobing,ZHANG Dawei, CHEN Renjie. A case of middle-ear anaplastic large T- cell lymphoma and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 7-14.
[8] JIN Xiaoxue, HAN Yingying, GUO Ruixiang, NI Shoujie, ZOU Juanjuan, WANG Yan, LI Yanzhong. Correlation between allergy factors and maxillofacial malformation in children with tonsil and adenoid hypertrophy in denture replacement period [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 45-50.
[9] HAN Yingying,LI Yanzhong. Obstructive sleep apnea hypopnea syndrome and subclinical arteriosclerosis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 126-132.
[10] YANG Xijun, GUAN Jian,WU Haiying. Research progress on the relationship between obstructive sleep apnea-hypopnea syndrome and dyslipidemia [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 133-138.
[11] CHEN Kun, LU Hui, HUANG Qi, LI Lei, MENG Guozhen, YANG Jun, HOU Dongming. Clinical diagnosis and treatment of congenital nasal sinus mass in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 81-85.
[12] SHI Xiaoli, MU Hong. Multidisciplinary diagnosis and treatment of a child with severe obstructive sleep apnea syndrome complicated by pulmonary hypertension [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 116-119.
[13] YUAN Chenyang, LIU Yan, FANG Zhensheng. Advances on the effect of OSAHS on pulmonary function in children [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(1): 143-148.
[14] WANG Junxin,SUN Yan. Research progress of miRNA-29b involved in EMT-related signaling pathway regulation [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 132-137.
[15] ZHANG Xiaoyan, HAO Xiaofeng,XIE Like. The application and progress of optical coherence topography in choroidal osteoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 138-141.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] LIN Bin,WANGHui-ge . Functional endoscopic sinus surgery, FESS[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(6): 481 -487 .
[2] GONG Lei,SUN Jie,XUE Zi-chao,LI Jing-hua,XUE Wei-guo . DNA analysis of the cell cycle in sino-nasal neoplasm[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 193 -195 .
[3] CHEN Wen-wen . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(5): 472 -472 .
[4] LUAN Jiangang,LIANG Chuanyu,WEN Yanjun,LI Jiong . Construction of RNAi expressing plasmid vector of pSIRENshuttle for EGFR gene silencing[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 4 -8 .
[5] MA Jing, ZHONG Cui-ping . Surgical method for nasopharyngeal fibroangioma encroaching on fossa pterygopalatina: with a report of 5 cases[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 30 -32 .
[6] LIU Qiang-he,LUO Xiang-lin,GENG Wan-ping,CHEN Chen,LEI Xun,LIU Fang-xian,DENG Ming . Age-related spiral ganglion neuron damages and hearing loss in senescence accelerated mice[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 215 -217 .
[7] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 223 -226 .
[8] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 246 -247 .
[9] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 250 -252 .
[10] . [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 260 -262 .