Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (5): 83-87.doi: 10.6040/j.issn.1673-3770.0.2021.147

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Research progress on the protective mechanism of heat shock protein 72 in glaucoma retinal ganglion cells

ZHAO Ying, ZHANG ShanOverview,XU Jiajun, ZHAO JingruGuidance   

  1. Department of Ophthalmology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • Published:2022-09-20

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Abstract: Glaucoma is a degenerative optic neuropathy, and is characterized by irreversible and progressive visual impairment. The protection of retinal ganglion cells from further damage of optic nerve has become the focus of glaucoma research. HSP72 is one of the important members of heat shock protein family. It is an inhibitor of apoptosis and has a close relationship with neuroprotection. Studies on the anti-apoptotic and cytoprotective properties of HSP72 in glaucoma retinal ganglion cells have important guiding significance for theoretical research and clinical treatment of the pathogenesis of glaucoma. This article reviews the protective effects of HSP72 in glaucomatous retinal ganglion cells.

Key words: HSP72, Glaucoma, Retinal ganglion cells, Protection mechanism

CLC Number: 

  • R775.9
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