Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2022, Vol. 36 ›› Issue (6): 77-82.doi: 10.6040/j.issn.1673-3770.0.2022.312

• 论著 • Previous Articles    

Clinical efficacy of intratympanic administration of budesonide combined with ambroxol hydrochloride in the treatment of secretory otitis media in adults

SUN Yan, YAO Hao, GU Li'an   

  1. Department of Otorhinolaryngology, Changshu No.1 People's Hospital (Changshu Hospital Affiliated to Soochow University), Changshu 215500, Jiangsu, China
  • Published:2022-12-07

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Abstract: Objective The aim of this study was to investigate the clinical efficacy of intratympanic injection comprising budesonide combined with ambroxol hydrochloride in treating secretory otitis media in adults. Methods Sixty patients with secretory otitis media who were selected and divided randomly into three groups; the observation, control, and experimental groups, each with 20 patients. The observation group received tympanocentesis and drainage; the control group was administered intratympanic ambroxol hydrochloride, and the experimental group was administered intratympanic budesonide combined with ambroxol hydrochloride. The three groups were compared prior and after the treatment with regard to the total effective rate of disease control, level of inflammatory response-related indexes, ear function-related indexes, time taken for symptom disappearance, time taken to recover based on the examination results of the internal ear, and incurrence of any adverse reactions. Results The total effective rate of disease control in patients in the experimental group was higher than those in the observation and control groups(all P<0.001). The level of inflammatory response- and ear function-related indexes in the experimental group before and after treatment improved more significantly than those in the observation and control groups(all P<0.001); the time taken for symptom disappearance and normal recovery in the experimental group was shorter than those in the observation and control groups(all P<0.001); no significantly different adverse reactions were observed between the three groups(P=0.804). Conclusions Treatment of patients with secretory otitis media by intratympanic injection of budesonide combined with ambroxol hydrochloride can effectively control the inflammatory response, improve the inflammatory indexes and ear function, shorten the treatment time, and improve the total treatment efficiency.

Key words: Secretory otitis media, Budesonide, Ambroxol hydrochloride, Intratympanic injection

CLC Number: 

  • R764.21
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