Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2023, Vol. 37 ›› Issue (1): 35-40.doi: 10.6040/j.issn.1673-3770.0.2021.494

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The bacteriological characteristics and drug sensitivity of the oropharyngeal region in children and adults with OSAHS

ZHANG Xiaoxue1, WANG Wei2, LIU Jie1, XU Zhenju1, QIAN Yongheng1, HAN Min1   

  1. 1. Department of Otorhinolaryngology & Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266071, Shandong, China;
    2. Department of Cardivascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266071, Shandong, China
  • Published:2023-02-06

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Abstract: Objective To analyze the difference of oropharyngeal flora between children and adults with obstructive sleep apnea hypopnea syndrome(OSAHS)and the results of drug sensitivity, so as to provide reference basis for rational selection of antibiotics in OSAHS patients after surgery. Methods OSAHS patients diagnosed by polysleep monitoring and treated by surgery in the Department of Otolaryngology Head and Neck Surgery of the Affiliated Hospital of Qingdao University from January 2018 to October 2021 were selected as the research objects. They were divided into children group and adults group according to age. After admission, some oropharyngeal secretions of the two groups were timely sent for bacterial culture and drug sensitivity analysis, to compare the oropharyngeal flora and drug sensitivity between children with OSAHS and adults with OSAHS. Results A total of 78 strains of pathogenic bacteria were isolated and cultured in 66 of 211 patients, with a positive rate of 31.28%, including 55 strains of Gram-positive cocci(70.51%), 29 strains of Staphylococcus aureus(37.18%)and 18 strains of Streptococcus pneumoniae(23.08%)were the main strains; there were 19 strains of Gram-negative bacilli(24.36%), mainly 15 strains of Haemophilus influenzae(19.23%). There was significant difference in detection rate of pathogenic bacteria between children group and adults group. There was significant difference in Streptococcus pneumoniae between the two groups, the detection rate of Streptococcus pneumoniae in children group was higher than that in adults group; there was no significant difference between Staphylococcus aureus and Haemophilus influenzae in the two groups. Streptococcus pneumoniae had high resistance rate to tetracycline, clindamycin and erythromycin. The resistance rate of Staphylococcus aureus to penicillin was high, and the drug resistance rates of Haemophilus influenzae to ampicillin, cefaclor, cotrimoxazole and cefuroxime were high. Conclusion The empirical application of antibiotics to prevent and treat infection after OSAHS surgery should be treated differently between children and adults patients, and the antimicrobial regimen should be adjusted according to the drug sensitivity results to slow down the production of drug-resistant bacteria.

Key words: Obstructive sleep apnea hypopnea syndrome, Children, Adults, Bacterial culture, Drug sensitivity test

CLC Number: 

  • R766.49
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