JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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YUAN Zhong-fang1,WEI Zeng-tao1, WANG Xiao-yan2   

  1. 1. Department of Ophthalmology, Jinan Central Hospital, Jinan 250013, Shandong, China;2. Institute of Immunology, School of Medicine, Shandong University, Jinan 250012, Shandong, China
  • Received:2005-10-01 Revised:1900-01-01 Online:2006-12-24 Published:2006-12-24
  • Contact: YUAN Zhong-fang

Abstract: To investigate the effects of recombinant human endostatin on corneal neovascularization (CNV). Methods: Alkanli burn was used to induce neovascularization in 18 New Zealand white rabbits, which were divided into 3 groups at random, 6 in each. 10?μg/ml and 50?μg/ml recombinant human endostatin were used respectively in group 1 and 2, and normal saline in group 3 (control). The area of CNV was determined by computer imaging analysis system. Results: The mean area of CNV of group 1 and 2 was significantly smaller than that of the control group from the 7th day(P＜0.05). No significant difference was found between group 1 and 2. Conclusion: Recombinant human endostatin has prominent effect in inhibiting the corneal angiogenesis.

Key words: Burn, Endostatin, chemical, Corneal neovascularization

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