疫苗相关性葡萄膜炎的临床特征分析:基于美国疫苗不良事件报告系统的回顾性研究

doi:10.6040/j.issn.1673-3770.0.2023.044

Abstract

Abstract: Objective To investigate the clinical characteristics of vaccine-associated uveitis in order to provide a reference for vaccine safety monitoring, vaccination, and clinical diagnosis and treatment. Methods The vaccine-associated uveitis reports from 1990 to 2022 were collected from the American Vaccine Adverse Event Reporting System. Moreover, sex, age, type of vaccination, dose series, time of occurrence, and type of uveitis of vaccine-associated uveitis reports were retrospectively analyzed. Results Of the 317 cases of vaccine-associated uveitis, more than 10 types of vaccine were involved, mainly the COVID-19 vaccine, human papillomavirus vaccine, and hepatitis B vaccine. There were 86 males and 231 females, with a male-to-female ratio of 1:2.7. Patients aged 18-<60 years, accounted for the majority of the total cases(65.3%). Uveitis is common under 8 days after vaccination and after the first dose of vaccination, accounting for 56.8% and 47.0%, respectively. Iridocyclitis represented the highest proportion of 184(56.5%)cases of uveitis. Conclusion Fully understand and study this adverse reaction to vaccination in depth, continue to monitor vaccine safety, better vaccination, and clinical diagnosis and treatment.

Key words: Vaccine, Uveitis, Vaccine adverse event reporting system, Adverse reaction

CLC Number:

R773

HOU Ning, YANG Junxing, ZHANG Yupeng, LIN Zichun, DENG Aijun. Analysis of clinical characteristics of vaccine-associated uveitis: a retrospective study based on American vaccine adverse event reporting system[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(2): 13-17.

References 23

[1]	Walton LR, Orenstein WA, Pickering LK. The history of the United States advisory committee on immunization practices(ACIP)[J]. Vaccine, 2015, 33(3): 405-414. doi:10.1016/j.vaccine.2014.09.043
[2]	马春霞, 周健. 引起葡萄膜炎的常见疫苗及发病机制[J]. 空军军医大学学报, 2023, 44(10): 1011-1015. doi:10.13276/j.issn.2097-1656.2023.10.019 MA Chunxia, ZHOU Jian. Common vaccines causing uveitis and their pathogenesis[J]. Journal of Air Force Medical University, 2023, 44(10): 1011-1015. doi:10.13276/j.issn.2097-1656.2023.10.019
[3]	Benage M, Fraunfelder FW. Vaccine-associated uveitis[J]. Mo Med, 2016, 113(1): 48-52
[4]	Kuniyoshi K, Hatsukawa Y, Kimura S, et al. Acute bilateral photoreceptor degeneration in an infant after vaccination against measles and Rubella[J]. JAMA Ophthalmol, 2017, 135(5): 478-482. doi:10.1001/jamaophthalmol.2017.0380
[5]	Nyankerh CNA, Boateng AK, Appah M. Ocular complications after COVID-19 vaccination, vaccine adverse event reporting system[J]. Vaccines, 2022, 10(6): 941. doi:10.3390/vaccines10060941
[6]	张博, 郭代红, 郭海丽, 等. 基于美国疫苗不良事件报告系统的新型冠状病毒肺炎疫苗相关不良事件报告分析[J]. 中国药物应用与监测, 2021, 18(2): 114-117. doi: 10.3969/j.issn.1672-8157.2021.02.012 ZHANG Bo, GUO Daihong, GUO Haili, et al. Analysis of COVID-19 vaccine-related adverse event reports based on the American vaccine adverse event reporting system[J]. Chinese Journal of Drug Application and Monitoring, 2021, 18(2): 114-117. doi: 10.3969/j.issn.1672-8157.2021.02.012
[7]	刘云霞, 胡海鹏, 张秀萍. 223例急性前葡萄膜炎的临床特征及治疗分析[J]. 山东大学耳鼻喉眼学报, 2012, 26(4): 64-65. doi: 10.6040/j.issn.1673-3770.2012.04.025 LIU Yunxia, HU Haipeng, ZHANG Xiuping. Clinical characteristics and treatment of 223 patients with acute anterior uveitis[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2012, 26(4): 64-65. doi: 10.6040/j.issn.1673-3770.2012.04.025
[8]	Singh RB, Parmar UPS, Kahale F, et al. Vaccine-associated uveitis after COVID-19 vaccination: vaccine adverse event reporting system database analysis[J]. Ophthalmology, 2023, 130(2): 179-186. doi:10.1016/j.ophtha.2022.08.027
[9]	Agarwal M, Dutta Majumder P, Babu K, et al. Drug-induced uveitis: a review[J]. Indian J Ophthalmol, 2020, 68(9): 1799-1807. doi:10.4103/ijo.IJO_816_20
[10]	Duffy J, Marquez P, Dores GM, et al. Safety surveillance of bivalent meningococcal group B vaccine, vaccine adverse event reporting system, 2014-2018[J]. Open Forum Infect Dis, 2020, 7(12): ofaa516. doi:10.1093/ofid/ofaa516
[11]	Klein SL, Flanagan KL. Sex differences in immune responses[J]. Nat Rev Immunol, 2016, 16(10): 626-638. doi:10.1038/nri.2016.90
[12]	邢凯, 涂晓燕, 刘苗, 等. COVID-19疫苗的有效性和安全性的系统评价[J]. 中国当代儿科杂志, 2021, 23(3): 221-228. doi:10.7499/j.issn.1008-8830.2101133 XING Kai, TU Xiaoyan, LIU Miao, et al. Effcacy and safety of COVID-19 vaccines: a systematic review[J]. Chinese Journal of Contemporary Pediatrics, 2021, 23(3): 221-228. doi:10.7499/j.issn.1008-8830.2101133
[13]	Fraunfelder FW, Suhler EB, Fraunfelder FT. Hepatitis B vaccine and uveitis: an emerging hypothesis suggested by review of 32 case reports[J]. Cutan Ocul Toxicol, 2010, 29(1): 26-29. doi: 10.3109/15569520903427717
[14]	刘岩, 王节涛, 杨北方, 等. 基于2006—2021年疫苗不良事件报告系统的人乳头瘤病毒疫苗的安全性分析[J]. 中国生物制品学杂志, 2023, 36(8): 955-961. doi:10.13200/j.cnki.cjb.003760 LIU Yan, WANG Jietao, YANG Beifang, et al. Safety of human papilloma virus vaccine based on vaccine adverse event reporting system from 2006 to 2021[J]. Chinese Journal of Biologicals, 2023, 36(8): 955-961. doi:10.13200/j.cnki.cjb.003760
[15]	Jackson LA, Anderson EJ, Rouphael NG, et al. An mRNA vaccine against SARS-CoV-2-preliminary report[J]. N Engl J Med, 2020, 383(20): 1920-1931. doi: 10.1056/NEJMoa2022483
[16]	Pang KP, Pan LJ, Guo H, et al. Case report: associated ocular adverse reactions with inactivated COVID-19 vaccine in China[J]. Front Med(Lausanne), 2021, 8: 823346. doi:10.3389/fmed.2021.823346
[17]	ElSheikh RH, Haseeb A, Eleiwa TK, et al. Acute uveitis following COVID-19 vaccination[J]. Ocul Immunol Inflamm, 2021, 29(6): 1207-1209. doi:10.1080/09273948.2021.1962917
[18]	Renisi G, Lombardi A, Stanzione M, et al. Anterior uveitis onset after bnt162b2 vaccination: is this just a coincidence?[J]. Int J Infect Dis, 2021, 110: 95-97. doi:10.1016/j.ijid.2021.07.035
[19]	Dansingani KK, Suzuki M, Naysan J, et al. Panuveitis with exudative retinal detachments after vaccination against human Papilloma virus[J]. Ophthalmic Surg Lasers Imaging Retina, 2015, 46(9): 967-970. doi:10.3928/23258160-20151008-11
[20]	Cunningham ET, Moorthy RS. Vaccine-associated posterior uveitis[J]. Retin Cases Brief Rep, 2022, 16(1): 1-4. doi:10.1097/icb.0000000000000958
[21]	孙一鑫, 刘志科, 詹思延. 疫苗上市后安全性准实时监测的概括性评价[J]. 中国药物警戒, 2023, 20(1): 61-67. doi: 10.19803/j.1672-8629.20220619 SUN Yixin, LIU Zhike, ZHAN Siyan. Scoping review of near real-time surveillance of vaccine safety[J]. Chinese Journal of Pharmacovigilance, 2023, 20(1): 61-67. doi: 10.19803/j.1672-8629.20220619
[22]	Moro PL, Haber P, McNeil MM. Challenges in evaluating post-licensure vaccine safety: observations from the Centers for Disease Control and Prevention[J]. Expert Rev Vaccines, 2019, 18(10): 1091-1101. doi:10.1080/14760584.2019.1676154
[23]	刘砚韬, 林芸竹, 陈力, 等. 基于VAERS的轮状病毒疫苗不良反应信号挖掘和数据分析[J]. 中国医院药学杂志, 2021, 41(5): 527-532. doi:10.13286/j.1001-5213.2021.05.15 LIU Yantao, LIN Yunzhu, CHEN Li, et al. Data analysis and signal excavation of rotavirus vaccine induced ADR based upon the VAERS[J]. Chinese Journal of Hospital Pharmacy, 2021, 41(5): 527-532. doi:10.13286/j.1001-5213.2021.05.15

Metrics

Viewed

Full text

275

HTML			PDF

Just accepted	Online first	Issue	Just accepted	Online first	Issue
0	0	0	0	0	275

From	Others	local

Times	12	263
Rate	4%	96%

Abstract

311

Just accepted	Online first	Issue

0	0	311

From	Others	local

Times	310	1
Rate	100%	0%

Cited

Web of Science	Crossref	ScienceDirect	Search for Citations in Google Scholar >>


This page requires you have already subscribed to WoS.

Shared

Discussed

Comments

Recommended 10

[1]	. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 84 -87 .
[2]	NIU Shanli,CHAI Maowen,LI Zhenxiu . Endoscopic rhinoplasty of inferior turbinate in 60 patients with chronic hypertrophic rhinitis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2006, 20(1): 16 -18 .
[3]	MENG Qing-guo,LU Yong-tian,FAN Xian-liang . Association of killer cell immunoglobulin-like receptor gene polymorphisms with nasopharyngeal carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 196 -199 .
[4]	. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 199 -199 .
[5]	WAN Li-jia,LU Hai-tao,JIANG Yi-dao,LIU Hui,LI Qin,SHE La-zhi . Effect of H-uvulopalatopharyngoplasty on obstructive sleep apnea hypopnea syndrome[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 204 -205 .
[6]	. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 222 -224 .
[7]	JI Xiao-bin,DENG Jia-de,ZANG Lin-quan,WANG Lei,XIE Jun . Blood histamine in guinea pigs with allergic rhinitis[J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 228 -230 .
[8]	XIANG Deng,LU Yong-tian,SUN Huan-ji . Endoscopic repair for cerebrospinal fluid rhinorrhea in 19 cases and a literature review [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 234 -236 .
[9]	. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 253 -257 .
[10]	YIN Guo-hua,ZHONG Xiao . Long-term effect of laser reduction on lingua adenoids [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(3): 280 -282 .

Analysis of clinical characteristics of vaccine-associated uveitis: a retrospective study based on American vaccine adverse event reporting system

PDF (PC)

Abstract

Cite this article

share this article

References 23

Related Articles 9

Metrics

Comments

Recommended 10

[1]	AI Ziqin, LI Junzheng. Advances in immune vaccines for head and neck squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(2): 143-150.
[2]	SHI Boying, LIANG Hao, LI Yihong, TANG Dongyong. Surgical treatment of a cataract complicated by anti-glaucoma surgery in an adult patient with Blau syndrome [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(6): 60-65.
[3]	CIREN Qiongda, WU Yuan. A case of long-term ocular complications caused by toxic epidermal necrolysis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(6): 147-150.
[4]	WANG Tan, WU Ke, LI Lianqing, GONG Lili. Factors associated with systemic adverse reactions after subcutaneous immunotherapy injections and treatment options [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 71-74.
[5]	WANG Zengzhi. Immunosuppressive treatment for non-infectious uveitis and its effect on cytokines [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2015, 29(6): 64-67.
[6]	DING Feng-kui1, SU Wan-yuan2, LI Qiao-yun1, LI Chuan-bao2. Compound trabeculectomy on secondary glaucoma following anterior uveitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2011, 25(5): 105-.
[7]	YANG Jun1， SUN Yan1, ZHAO Jun1, HAN Jing-li2. Surgical treatment for secondary glaucoma - in uveitis with cataract [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(5): 53-55.
[8]	LI Li-li1， BI Hong-sheng2， XIE Xiao-feng2， GUO Jun-guo3. Clinical efficacy of Qingkailing ophthalmic gel for 80 cases of chronic uveitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2010, 24(4): 62-.
[9]	CAI Wan-ting,BI Hong-sheng,WU Jian-feng,XIE Xiao-feng,LIU Dong-mei . Effect of phacoemulsification in the treatment of complicated cataracts induced by uveitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2008, 22(1): 10-12 .