ISSN 1673-3770 CN 37-1437/R
Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2024, Vol. 38 ›› Issue (6): 1-14.doi: 10.6040/j.issn.1673-3770.0.2024.396
• Multidisciplinary Diagnosis and Treatment of Laryngopharyngeal Reflux Related Diseases •
WU Wei1, WANG Lei1, CHEN Sheng2, LI Lianyong2, WANG Gang1
CLC Number:
| [1] Cherry J, Margulies SI. Contact ulcer of the larynx[J]. Laryngoscope, 1968, 78(11): 1937-1940. doi:10.1288/00005537-196811000-00007 [2] Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease(GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury[J]. Laryngoscope, 1991, 101(4 Pt 2 Suppl 53): 1-78. doi:10.1002/lary.1991.101.s53.1 [3] Wiener GJ, Koufman JA, Wu WC, et al. Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pH monitoring[J]. Am J Gastroenterol, 1989, 84(12): 1503-1508 [4] Koufman JA, Aviv JE, Casiano RR, et al. Laryngopharyngeal reflux: position statement of the committee on speech, voice, and swallowing disorders of the American Academy of Otolaryngology-Head and Neck Surgery[J]. Otolaryngol Head Neck Surg, 2002, 127(1): 32-35. doi:10.1067/mhn.2002.125760 [5] 中华耳鼻咽喉头颈外科杂志编辑委员会咽喉组, 中华医学会耳鼻咽喉头颈外科学分会咽喉学组. 咽喉反流性疾病诊断与治疗专家共识(2015年)[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(5): 324-326. doi:10.3760/cma.j.issn.1673-0860.2016.05.002 Subspecialty Group of Laryngopharyngology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Subspecialty Group of Laryngopharyngology, Society of Otorhinolaryngology Head and Neck Surgery. Chinese Medical Association.Experts consensus on diagnosis and treatment of laryngopharyngeal reflux disease(2015)[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2016, 51(5): 324-326. doi:10.3760/cma.j.issn.1673-0860.2016.05.002 [6] 中华耳鼻咽喉头颈外科杂志编辑委员会咽喉组, 中华医学会耳鼻咽喉头颈外科学分会咽喉学组, 中华医学会耳鼻咽喉头颈外科学分会嗓音学组. 咽喉反流性疾病诊断与治疗专家共识(2022年,修订版)[J]. 中华耳鼻咽喉头颈外科杂志, 2022, 57(10): 1149-1172. doi:10.3760/cma.j.cn115330-20220711-00428 Subspecialty Group of Laryngopharyngology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Subspecialty Group of Laryngopharyngology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association; Subspecialty Group of Voice, Society of Otorhinolaryngology Head and Neck Surgery,Chinese Medical Association. Experts consensus on diagnosis and treatment of laryngopharyngeal reflux disease(2022, revision)[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2022, 57(10): 1149-1172. doi:10.3760/cma.j.cn115330-20220711-00428 [7] 汪忠镐. 胃食反流与呼吸道疾病:胃食管喉气管综合征[M].2版,北京: 人民卫生出版社, 2017:2-5 [8] 汪忠镐,宁雅婵,吴继敏,等. 反流引起的呼吸道表现:胃食管气道反流机器误诊误治疗[J]. 临床误诊误治, 2011, 24(3): 1-4. doi: 10.3969/j.issn.1002-3429.2011.03.001 WANG Zhonggao, NING Yachan, WU Jimin, et al. Airway Presentations due to Reflux:Gastroesophageal Airway Reflux and Its Misdiagnosis and Mistherapy[J]. Clinical Misdiagnosis & Mistherapy, 2011, 24(3): 1-4. doi: 10.3969/j.issn.1002-3429.2011.03.001 [9] 吴玮,王刚,徐小杭,等.胃食管气道反流性疾病提出的依据及意义[J].中国医学文摘耳鼻咽喉科学,2018,33(1):14-17. doi:10.19617/j.issn1001-1307.2018.01.014. Wu Wei, Wang Gang, Xu Xiaohang, et al. Evidence and significance of gastroesophago-airway reflux disease[J]. Chinese Medical Digest:Otorhinolaryngology, 2018, 33(1): 14-17. doi:10.19617/j.issn1001-1307.2018.01.014. [10] 王磊,王刚,吴玮,等. 口咽、食道同步Dx-pH检测研究咽喉反流性疾病[J].山东大学耳鼻喉眼学报, 2019, 33(5): 101-106. doi:10.6040/j.issn.1673-3770.0.2019.114 WANG Lei, WANG Gang, WU Wei, et al. Simultaneous Dx-pH monitoring of the oropharynx and esophagus for laryngopharyngeal reflux disease research[J]. J Otolaryngol Ophthalmol Shandong Univ, 2019, 33(5): 101-106. doi:10.6040/j.issn.1673-3770.0.2019.114 [11] 中国医疗保健国际交流促进会胃食管反流多学科分会. 中国胃食管反流病多学科诊疗共识[J]. 中国医学前沿杂志(电子版), 2019, 11(9): 30-56. doi:10.12037/YXQY.2019.09-06 [12] Sharma N, Agrawal A, Freeman J, et al. An analysis of persistent symptoms in acid-suppressed patients undergoing impedance-pH monitoring[J]. Clin Gastroenterol Hepatol, 2008, 6(5): 521-524. doi:10.1016/j.cgh.2008.01.006 [13] Bulmer DM, Ali MS, Brownlee IA, et al. Laryngeal mucosa: its susceptibility to damage by acid and pepsin[J]. Laryngoscope, 2010, 120(4): 777-782. doi:10.1002/lary.20665 [14] Campagnolo AM, Priston J, Thoen RH, et al. Laryngopharyngeal reflux: diagnosis, treatment, and latest research[J]. Int Arch Otorhinolaryngol, 2014, 18(2): 184-191. doi:10.1055/s-0033-1352504 [15] Im NR, Lee DY, Kim B, et al. Role of Matrix Metalloproteinases 7 in the Pathogenesis of Laryngopharyngeal Reflux: decreased E-cadherin in Acid exposed Primary Human Pharyngeal Epithelial Cells[J]. Int J Mol Sci, 2019, 20(21): 5276. doi:10.3390/ijms20215276 [16] Bao YY, Jiang Q, Li ZW, et al. Gastric H+/K+-ATPase expression in normal laryngeal tissue and laryngeal carcinoma[J]. Onco Targets Ther, 2020, 13: 12919-12931. doi:10.2147/OTT.S276233 [17] McCormick CA, Samuels TL, Battle MA, et al. H+/K+ATPase Expression in the Larynx of Laryngopharyngeal Reflux and Laryngeal Cancer Patients[J].Laryngoscope,2021,131(1):130-135. doi:10.1002/lary.28643 [18] 崔小缓, 尹龙龙, 张延平, 等. 咽喉反流患者唾液菌群与反流症状相关性分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(6):78-84. doi:10.6040/j.issn.1673-3770.0.2024.111 CUI Xiaohuan, YIN Longlong, ZHANG Yanping, et al. Study of the association between salivary microbiota and reflux symptoms in patients with laryngopharyngeal reflux[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6):78-84. doi:10.6040/j.issn.1673-3770.0.2024.111 [19] Ali MS, Parikh S, Chater P, et al. Bile acids in laryngopharyngeal refluxate: will they enhance or attenuate the action of pepsin?[J]. Laryngoscope. 2013, 123(2): 434-439. doi:10.1002/lary.28643 [20] Formánek M, Jan catová D, Komínek P, et al. Laryngopharyngeal reflux and herpes simplex virus type 2 are possible risk factors for adult-onset recurrent respiratory papillomatosis(prospective case-control study)[J]. Clin Otolaryngol, 2017, 42(3): 597-601. doi:10.1111/coa.12779 [21] Poelmans J, Tack J, Feenstra L. Paroxysmal laryngospasm: a typical but underrecognized supraesophageal manifestation of gastroesophageal reflux?[J]. Dig Dis Sci, 2004, 49(11): 1868-1874. doi:10.1007/s10620-004-9585-0 [22] Johnston N, Dettmar PW, Lively MO, et al. Effect of pepsin on laryngeal stress protein(Sep70, Sep53, and Hsp70)response: role in laryngopharyngeal reflux disease[J]. The Annals of otology, rhinology, and laryngology. 2006, 115(1): 47-58. doi:10.1002/lary.28643 [23] Johnston N, Wells CW, Samuels TL, et al. Rationale for targeting pepsin in the treatment of reflux disease[J]. Ann Otol Rhinol Laryngol, 2010, 119(8): 547-558. doi:10.1177/000348941011900808 [24] Yin CY, Zhang SS, Zhong JT, et al. Pepsin and laryngeal and hypopharyngeal carcinomas[J]. Clin Exp Otorhinolaryngol, 2021, 14(2): 159-168. doi:10.21053/ceo.2020.00465 [25] Chen YL, Bao YY, Zhou SH, et al. Relationship between pepsin expression and dysplasia grade in patients with vocal cord leukoplakia[J]. Otolaryngol - head Neck Surg, 2021, 164(1): 160-165. doi:10.1177/0194599820938654 [26] 牛燕燕, 顾伟, 金晓峰, 等. 声带白斑组织中胃蛋白酶的表达分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 66-70. doi:10.6040/j.issn.1673-3770.0.2024.073 NIU Yanyan, GU Wei, JIN Xiaofeng, et al. Expression analysis of pepsin in vocal cord leukoplakia tissues[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6):66-70. doi:10.6040/j.issn.1673-3770.0.2024.073 [27] El-Serag HB, Hepworth EJ, Lee P, et al. Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer[J]. Am J Gastroenterol, 2001, 96(7): 2013-2018. doi:10.1111/j.1572-0241.2001.03934.x [28] Johnston N, Yan JC, Hoekzema CR, et al. Pepsin promotes proliferation of laryngeal and pharyngeal epithelial cells[J]. Laryngoscope, 2012, 122(6): 1317-1325. doi:10.1002/lary.23307 [29] Tan JJ, Wang L, Mo TT, et al. Pepsin promotes IL-8 signaling-induced epithelial-mesenchymal transition in laryngeal carcinoma[J]. Cancer Cell Int, 2019, 19: 64. doi:10.1186/s12935-019-0772-7 [30] Gotley DC, Morgan AP, Cooper MJ. Bile acid concentrations in the refluxate of patients with reflux oesophagitis[J]. Br J Surg, 1988, 75(6): 587-590. doi:10.1002/bjs.1800750632 [31] Aldhahrani A, Powell J, Ladak S, et al. The potential role of bile acids in acquired laryngotracheal stenosis[J]. Laryngoscope, 2018, 128(9): 2029-2033. doi:10.1002/lary.27105 [32] Sereg-Bahar M, Jerin A, Hocevar-Boltezar I. Higher levels of total pepsin and bile acids in the saliva as a possible risk factor for early laryngeal cancer[J]. Radiol Oncol, 2015, 49(1): 59-64. doi:10.2478/raon-2014-0020 [33] Vageli DP, Prasad ML, Sasaki CT. Gastro-duodenal fluid induced nuclear factor-κappaB activation and early pre-malignant alterations in murine hypopharyngeal mucosa[J]. Oncotarget, 2016, 7(5): 5892-5908. doi:10.18632/oncotarget.6824 [34] Doukas SG, Cardoso B, Tower JI, et al. Biliary tumorigenic effect on hypopharyngeal cells is significantly enhanced by pH reduction[J]. Cancer Med, 2019, 8(9): 4417-4427. doi:10.1002/cam4.2194 [35] Sasaki CT, Doukas SG, Doukas PG, et al. Weakly Acidic Bile Is a Risk Factor for Hypopharyngeal Carcinogenesis Evidenced by DNA Damage, Antiapoptotic Function, and Premalignant Dysplastic Lesions In Vivo[J]. Cancers(Basel). 2021, 13(4):852. doi:10.1002/lary.28643 [36] Sasaki CT, Doukas SG, Costa J, et al. Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications[J]. Cancer. 2019, 125(20): 3554-65. doi:10.1002/lary.28643 [37] Sasaki CT, Doukas SG, Costa J, et al. The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights[J]. Cancers(Basel). 2020,12(5):1064. doi:10.1002/lary.28643 [38] Sasaki CT, Hajek M, Doukas SG, et al. The role of bile reflux and its related NF-κB activated pathway in progression of hypopharyngeal squamous cell cancer[J]. Oral Oncol, 2020, 105: 104668. doi:10.1016/j.oraloncology.2020.104668 [39] Li YD, Xu GF, Zhou BD, et al. Effects of acids, pepsin, bile acids, and trypsin on laryngopharyngeal reflux diseases: physiopathology and therapeutic targets[J]. Eur Arch Otorhinolaryngol, 2022, 279(6): 2743-2752. doi:10.1007/s00405-021-07201-w [40] Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index(RSI)[J]. J Voice, 2002, 16(2): 274-277. doi:10.1016/s0892-1997(02)00097-8 [41] Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score(RFS)[J]. Laryngoscope, 2001, 111(8): 1313-1317. doi:10.1097/00005537-200108000-00001 [42] Lechien JR, Schindler A, De Marrez LG, et al. Instruments evaluating the clinical findings of laryngopharyngeal reflux: a systematic review[J]. Laryngoscope. 2019, 129(3): 720-736. doi:10.1002/lary.28643 [43] Chang BA, MacNeil SD, Morrison MD, et al. The reliability of the reflux finding score among general otolaryngologists[J]. J Voice, 2015, 29(5): 572-577. doi:10.1016/j.jvoice.2014.10.009 [44] Wang G, Qu CM, Wang L, et al. Utility of 24-hour pharyngeal pH monitoring and clinical feature in laryngopharyngeal reflux disease[J]. Acta Otolaryngol, 2019, 139(3): 299-303. doi:10.1080/00016489.2019.1571280 [45] 王刚,吴玮,王磊,等.Ryan指数与反流症状指数量表、反流体征量表在咽喉反流性疾病诊断中的相关性分析[J].山东大学耳鼻喉眼学报, 2018, 32(4): 48-52. doi: 10.6040/ j. issn.1673-3770.0.2017.507 WANG Gang, WU Wei, WANG Lei, et al. Correlation analysis between Ryan index and reflux symptom index and reflux finding score, in the diagnosis of laryngopharyngeal reflux diseases[J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 48-52. doi:10.6040/ j. issn.1673-3770.0.2017.507 [46] Nacci A, Bastiani L, Barillari MR, et al. Assessment and Diagnostic Accuracy Evaluation of the Reflux Symptom Index(RSI)Scale: Psychometric Properties using Optimal Scaling Techniques[J]. Ann Otol Rhinol Laryngol, 2020, 129(10): 1020-1029. doi:10.1177/0003489420930034 [47] Lechien JR, Saussez S, Karkos PD. Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018[J]. Curr Opin Otolaryngol Head Neck Surg, 2018, 26(6): 392-402. doi:10.1097/MOO.0000000000000486 [48] Chen MX, Hou CJ, Chen T, et al. Reflux symptom index and reflux finding score in 91 asymptomatic volunteers[J]. Acta Otolaryngol, 2018, 138(7): 659-663. doi:10.1080/00016489.2018.1436768 [49] Avincsal MO, Altundag A, Ulusoy S, et al. Halitosis associated volatile sulphur compound levels in patients with laryngopharyngeal reflux[J]. Eur Arch Otorhinolaryngol. 2016, 273(6):1515-1520. doi: 10.1007/s00405-016-3961-1. [50] Hicks DM, Ours TM, Abelson TI, et al. The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteers[J]. J Voice, 2002, 16(4): 564-579. doi:10.1016/s0892-1997(02)00132-7 [51] Lechien JR, Bobin F, Muls V, et al. Validity and reliability of the reflux symptom score[J]. Laryngoscope, 2020, 130(3): E98-E107. doi:10.1002/lary.28017 [52] Lechien JR, Schindler A, Hamdan AL, et al. The development of new clinical instruments in laryngopharyngeal reflux disease: the international project of young otolaryngologists of the International Federation of Oto-rhino-laryngological Societies[J]. Eur Ann Otorhinolaryngol Head Neck Dis, 2018, 135(5S): S85-S91. doi:10.1016/j.anorl.2018.05.013 [53] Lechien JR, Bobin F, Rodriguez A, et al. Development and validation of the short version of the reflux symptom score: reflux symptom score-12[J]. Otolaryngol Head Neck Surg, 2021, 164(1): 166-174. doi:10.1177/0194599820941003 [54] 韩红蕾, 吕秋萍, 刘剑锋, 等. 反流症状评分量表中文版的信度和效度评估[J]. 中华耳鼻咽喉头颈外科杂志, 2022, 57(10): 1185-1190. doi:10.3760/cma.j.cn115330-20220531-00322 HAN Honglei, LYU Qiuping, LIU Jianfeng, et al. Evaluation of reliability and validity of the Chinese version of a new symptom score of laryngopharyngeal reflux disease[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2022, 57(10): 1185-1190. doi:10.3760/cma.j.cn115330-20220531-00322 [55] 郑小炜, 陈柳青, 陈婷, 等. 反流症状评分-12量表中文版信度和效度评价[J]. 中华耳鼻咽喉头颈外科杂志, 2022, 57(9): 1087-1094. doi:10.3760/cma.j.cn115330-20220303-00091 ZHENG Xiaowei, CHEN Liuqing, CHEN Ting, et al. Analysis of reliability and validity of the Chinese version of reflux symptom score 12[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2022, 57(9): 1087-1094. doi:10.3760/cma.j.cn115330-20220303-00091 [56] Lechien JR, Rodriguez Ruiz A, Dequanter D, et al. Validity and reliability of the reflux sign assessment[J]. Ann Otol Rhinol Laryngol, 2020, 129(4): 313-325. doi:10.1177/0003489419888947 [57] Lechien JR, Huet K, Khalife M, et al. Gender differences in the presentation of dysphonia related to laryngopharyngeal reflux disease: a case-control study[J]. Eur Arch Otorhinolaryngol, 2018, 275(6): 1513-1524. doi:10.1007/s00405-018-4951-2 [58] 魏鑫, 翟振伟, 邢东升, 等. 妊娠期女性咽喉反流症状指数调查及影响因素分析[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 96-102. doi:10.6040/j.issn.1673-3770.0.2024.046 WEI Xin, ZHAI Zhenwei, XING Dongsheng, et al. Study of the Laryngeal Reflux Symptom Index and analysis of influencing factors in pregnant women[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6):96-102. doi:10.6040/j.issn.1673-3770.0.2024.046 [59] Mendelsohn AH. The effects of reflux on the elderly: the problems with medications and interventions[J]. Otolaryngol Clin North Am, 2018, 51(4): 779-787. doi:10.1016/j.otc.2018.03.007 [60] 李超凡,张立红,王文伦,等.耳鼻咽喉科门诊患者咽喉反流性疾病、焦虑抑郁患病率及二者关系[J].中华耳鼻咽喉头颈外科杂志, 2020, 55(3): 241-248. doi:10.3760/cma.j. issn.16730860.2020.03.010 Li Chaofan, Zhang Lihong, Wang Wenlun, et al. The prevalence and relationship between laryngopharyngeal reflux disease, anxiety and depression in otolaryngology outpatients[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2020, 55(3): 241-248. doi:10.3760/cma.j. issn.16730860.2020.03.010 [61] 王磊, 王刚, 吴玮, 等. 精神心理因素对咽喉反流性疾病影响研究[J]. 实用医学杂志, 2019, 35(20): 3199-3203. doi:10.3969/j.issn.1006-5725.2019.20.017 Wang Lei, Wang Gang, Wu Wei, et al. Influence of psychological factors on laryngopharyngeal reflux disease[J]. The Journal of Practical Medicine, 2019, 35(20): 3199-3203. doi:10.3969/j.issn.1006-5725.2019.20.017 [62] Jaspersen D, Kulig M, Labenz J, et al. Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD Study[J]. Aliment Pharmacol Ther, 2003, 17(12): 1515-1520. doi:10.1046/j.1365-2036.2003.01606.x [63] Dore MP, Pedroni A, Pes GM, et al. Effect of antisecretory therapy on atypical symptoms in gastroesophageal reflux disease[J]. Dig Dis Sci, 2007, 52(2): 463-468. doi:10.1007/s10620-006-9573-7 [64] Lechien JR, Akst LM, Hamdan AL, et al. Evaluation and management of laryngopharyngeal reflux disease: state of the art review[J]. Otolaryngol Head Neck Surg, 2019, 160(5): 762-782. doi:10.1177/0194599819827488 [65] Jacob P, Kahrilas PJ, Herzon G. Proximal esophageal pH-metry in patients with ‘reflux laryngitis’[J]. Gastroenterology, 1991, 100(2): 305-310. doi:10.1016/0016-5085(91)90196-r [66] Eubanks TR, Omelanczuk PE, Maronian N, et al. Pharyngeal pH monitoring in 222 patients with suspected laryngeal reflux[J]. J Gastrointest Surg, 2001, 5(2): 183-190;discussion 190-191. doi:10.1016/s1091-255x(01)80032-9 [67] Kim SI, Jeong SJ, Kwon OE, et al. Pharyngeal reflux episodes in patients with suspected laryngopharyngeal reflux versus healthy subjects: a prospective cohort study[J]. Eur Arch Otorhinolaryngol, 2021, 278(9): 3387-3392. doi:10.1007/s00405-021-06865-8 [68] Golub JS, Johns MM 3rd, Lim JH, et al. Comparison of an oropharyngeal pH probe and a standard dual pH probe for diagnosis of laryngopharyngeal reflux[J]. Ann Otol Rhinol Laryngol, 2009, 118(1): 1-5. doi:10.1177/000348940911800101 [69] Horvath L, Hagmann P, Burri E, et al. Evaluation of oropharyngeal pH-monitoring in the assessment of laryngopharyngeal reflux[J]. J Clin Med, 2021, 10(11): 2409. doi:10.3390/jcm10112409 [70] Vailati C, Mazzoleni G, Bondi S, et al. Oropharyngeal pH monitoring for laryngopharyngeal reflux: is it a reliable test before therapy?[J]. J Voice, 2013, 27(1): 84-89. doi:10.1016/j.jvoice.2012.08.006 [71] Yuksel ES, Slaughter JC, Mukhtar N, et al. An oropharyngeal pH monitoring device to evaluate patients with chronic laryngitis[J]. Neurogastroenterol Motil. 2013, 25(5): 315-323. doi:10.1111/nmo.12109 [72] Sun G, Muddana S, Slaughter JC, et al. A new pH catheter for laryngopharyngeal reflux: normal values[J]. Laryngoscope, 2009, 119(8): 1639-1643. doi:10.1002/lary.20282 [73] Guo YZ, Wang G, Li LY, et al. Machine learning aided diagnosis of diseases without clinical gold standard: a new score for laryngopharyngeal reflux disease based on pH monitoring[J]. IEEE Access, 2020, 8: 67005-67014. doi:10.1109/ACCESS.2020.2985494 [74] Wang G, Wang L, Sun ZZ, et al. A comparison between W score and RYAN score in diagnosing laryngopharyngeal reflux disease[J]. J Voice, 2023: S0892-S1997(23)00174-1. doi:10.1016/j.jvoice.2023.06.001 [75] Gupta R, Sataloff RT. Laryngopharyngeal reflux: current concepts and questions[J]. Curr Opin Otolaryngol Head Neck Surg, 2009, 17(3): 143-148. doi:10.1097/MOO.0b013e32832b2581 [76] Chander B, Hanley-Williams N, Deng YH, et al. 24 versus 48-hour bravo pH monitoring[J]. J Clin Gastroenterol, 2012, 46(3): 197-200. doi:10.1097/mcg.0b013e31822f3c4f [77] 孙喆喆,王刚,王磊,等. 连续48 h口咽pH监测在咽喉反流性疾病中诊断作用的研究[J]. 中华耳鼻咽喉头颈外科杂志, 2022, 57(10): 1191-1196. doi:10.3760/cma.j.cn115330-20220530-00318 Sun Zhezhe, Wang Gang, Wang Lei, et al. The role of continuous 48 h oropharyngeal pH monitoring in the diagnosis of laryngopharyngeal reflux disease[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2022, 57(10):1191-1196. doi:10.3760/cma.j.cn115330-20220530-00318 [78] Vance D, Park J, Alnouri G, et al. Diagnosing laryngopharyngeal reflux: a comparison between 24-hour pH-impedance testing and pharyngeal probe(restech)testing, with introduction of the sataloff score[J]. J Voice, 2023, 37(5): 737-747. doi:10.1016/j.jvoice.2021.04.002 [79] Wang JY, Peng T, Zhao LL, et al. Poor consistency between reflux symptom index and laryngopharyngeal pH monitoring in laryngopharyngeal reflux diagnosis in Chinese population[J]. Ann Transl Med, 2021, 9(1): 25. doi:10.21037/atm-20-4783 [80] Bobin F, Journe F, Lechien JR. Saliva pepsin level of laryngopharyngeal reflux patients is not correlated with reflux episodes[J]. Laryngoscope, 2020, 130(5): 1278-1281. doi:10.1002/lary.28260 [81] Dhillon VK, Akst LM. How to approach laryngopharyngeal reflux: an otolaryngology perspective[J]. Curr Gastroenterol Rep, 2016, 18(8): 44. doi:10.1007/s11894-016-0515-z [82] Jing WY, Luo WL, Lou L. Diagnostic utility of salivary pepsin in laryngopharyngeal reflux: a systematic review and meta-analysis[J]. Braz J Otorhinolaryngol, 2023, 89(2): 339-347. doi:10.1016/j.bjorl.2022.10.050 [83] Calvo-Henríquez C, Ruano-Ravina A, Vaamonde P, et al. Is pepsin a reliable marker of laryngopharyngeal reflux? A systematic review[J]. Otolaryngol Head Neck Surg, 2017, 157(3): 385-391. doi:10.1177/0194599817709430 [84] Guo ZH, Jiang JL, Wu H, et al. Salivary peptest for laryngopharyngeal reflux and gastroesophageal reflux disease: a systemic review and meta-analysis[J]. Medicine, 2021, 100(32): e26756. doi:10.1097/MD.0000000000026756 [85] Klimara MJ, Johnston N, Samuels TL, et al. Correlation of salivary and nasal lavage pepsin with MII-pH testing[J]. Laryngoscope, 2020, 130(4): 961-966. doi:10.1002/lary.28182 [86] Na SY, Kwon OE, Lee YC, et al. Optimal timing of saliva collection to detect pepsin in patients with laryngopharyngeal reflux[J]. Laryngoscope, 2016, 126(12): 2770-2773. doi:10.1002/lary.26018 [87] 王磊, 李保卫, 王刚, 等. 阻塞性睡眠呼吸暂停低通气综合征患者夜间碱反流初步研究[J]. 山东大学耳鼻喉眼学报, 2023, 37(6): 75-79, 92. doi:10.6040/j.issn.1673-3770.0.2022.138 WANG Lei, LI Baowei, WANG Gang, et al. A preliminary study on nocturnal alkali reflux in OSAHS patients[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 75-79, 92. doi:10.6040/j.issn.1673-3770.0.2022.138 [88] Gupta N, Green RW, Megwalu UC. Evaluation of a laryngopharyngeal reflux management protocol[J]. Am J Otolaryngol, 2016, 37(3): 245-250. doi:10.1016/j.amjoto.2016.01.008 [89] 张杉, 陈秋, 周方伟, 等. 生物标志物在咽喉反流中的研究进展[J]. 山东大学耳鼻喉眼学报, 2024, 38(6): 46-54. doi:10.6040/j.issn.1673-3770.0.2024.122 ZHANG Shan, CHEN Qiu, ZHOU Fangwei, et al. Research progress of biomarkers in laryngeal reflux[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(6):46-54. doi:10.6040/j.issn.1673-3770.0.2024.122 [90] Ford CN. Evaluation and management of laryngopharyngeal reflux[J]. JAMA, 2005, 294(12): 1534-1540. doi:10.1001/jama.294.12.1534 [91] Lechien JR, Muls V, Dapri G, et al. The management of suspected or confirmed laryngopharyngeal reflux patients with recalcitrant symptoms: a contemporary review[J]. Clin Otolaryngol, 2019, 44(5): 784-800. doi:10.1111/coa.13395 [92] Lechien JR, Finck C, Khalife M, et al. Change of signs, symptoms and voice quality evaluations throughout a 3- to 6-month empirical treatment for laryngopharyngeal reflux disease[J]. Clin Otolaryngol, 2018, 43(5): 1273-1282. doi:10.1111/coa.13140 [93] Reichel O, Dressel H, Wiederänders K, et al. Double-blind, placebo-controlled trial with esomeprazole for symptoms and signs associated with laryngopharyngeal reflux[J]. Otolaryngol Head Neck Surg, 2008, 139(3): 414-420. doi:10.1016/j.otohns.2008.06.003 [94] Kinoshita Y, Ishimura N, Ishihara S. Advantages and disadvantages of long-term proton pump inhibitor use[J]. J Neurogastroenterol Motil, 2018, 24(2): 182-196. doi:10.5056/jnm18001 [95] Kahrilas PJ, Bredenoord AJ, Fox M, et al. The Chicago Classification of esophageal motility disorders, v3.0. Neurogastroenterol Motil. 2015, 27(2):160-174. doi:10.1111/nmo.12477 [96] Gosling J, Plumb A, Taylor SA, et al. High-resolution anal manometry: Repeatability, validation, and comparison with conventional manometry[J]. Neurogastroenterol Motil, 2019, 31(6): e13591. doi:10.1111/nmo.13591 [97] 中国医疗保健国际交流促进会胃食管反流病学分会. 中国胃食管反流病多学科诊疗共识2022(一)[J]. 中华胃食管反流病电子杂志, 2022, 9(2): 51-86. doi:10.3877/cma.j.issn.2095-8765.2022.02.001 [98] 陈梅香, 陈婷, 侯晨婕, 等. 咽部异物感患者的高分辨率食管测压结果分析[J]. 听力学及言语疾病杂志, 2016, 24(6): 576-579. doi:10.3969/j.issn.1006-7299.2016.06.011 CHEN Meixiang, CHEN Ting, HOU Chenjie, et al. The high resolution esophageal manometry(HRM)of pharyngeal paraesthesia patients[J]. Journal of Audiology and Speech Pathology, 2016, 24(6): 576-579. doi:10.3969/j.issn.1006-7299.2016.06.011 [99] Ylitalo R, Baugh A, Li WH, et al. Effect of acid and pepsin on gene expression in laryngeal fibroblasts[J]. Ann Otol Rhinol Laryngol, 2004, 113(11): 866-871. doi:10.1177/000348940411301104 [100] 刘凡理, 陈波蓓, 黄赛瑜, 等. 胃食管反流对咽喉反流病患者的食管动力学影响[J]. 中国中西医结合耳鼻咽喉科杂志, 2016, 24(6): 446-449. doi:10.16542/j.cnki.issn.1007-4856.2016.06.014 LIU Fanli, CHEN Bobei, HUANG Saiyu, et al. The effect of gastroesophageal reflux in esophageal dynamics of laryngopharyngeal reflux disease[J]. Chinese Journal of Otorhinolaryngology in Integrative Medicine, 2016, 24(6): 446-449. doi:10.16542/j.cnki.issn.1007-4856.2016.06.014 [101] Omari TI, Ciucci M, Gozdzikowska K, et al. High-resolution pharyngeal manometry and impedance: protocols and metrics-recommendations of a high-resolution pharyngeal manometry international working group[J]. Dysphagia, 2020, 35(2): 281-295. doi:10.1007/s00455-019-10023-y [102] Pisegna JM, Yang S, Purcell A, et al. A mixed-methods study of patient views on reflux symptoms and medication routines[J]. J Voice, 2017, 31(3): 15-25. doi:10.1016/j.jvoice.2016.06.024 [103] Lechien JR, Crevier-Buchman L, Distinguin L, et al. Is Diet Sufficient as Laryngopharyngeal Reflux Treatment? A Cross-Over Observational Study[J]. Laryngoscope. 2022, 132(10): 1916-1923. doi:10.1002/lary.29890 [104] Huestis MJ, Keefe KR, Kahn CI, Tracy LF, Levi JR. Alternatives to Acid Suppression Treatment for Laryngopharyngeal Reflux[J]. Ann Otol Rhinol Laryngol. 2020, 129(10): 1030-1039. doi:10.1177/0003489420922870 [105] Vora A, Vance D, Alnouri G, Sataloff RT. Food Sensitivity and Laryngopharyngeal Reflux: Preliminary Observations[J]. J Voice. 2021, 35(3): 497.e5-497.e7. doi:10.1016/j.jvoice.2019.09.005 [106] Kim SI, Lechien JR, Ayad T, et al. Management of Laryngopharyngeal Reflux in Asia[J]. Clin Exp Otorhinolaryngol. 2020, 13(3): 299-307. doi:10.21053/ceo.2019.01669 [107] Qadeer MA, Phillips CO, Lopez AR, et al. Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials[J]. Am J Gastroenterol, 2006, 101(11): 2646-2654. doi:10.1111/j.1572-0241.2006.00844.x [108] Chang AB, Lasserson TJ, Kiljander TO, Connor FL, Gaffney JT, Garske LA. Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux[J]. BMJ. 2006, 332(7532): 11-17. doi:10.1136/bmj.38677.559005.55 [109] Lee KJ, Son BK, Kim GH, et al. Randomised phase 3 trial: tegoprazan, a novel potassium-competitive acid blocker, vs. esomeprazole in patients with erosive oesophagitis[J]. Aliment Pharmacol Ther, 2019, 49(7): 864-872. doi:10.1111/apt.15185 [110] Samuels TL, Yan K, Patel N, et al. Alginates for Protection Against Pepsin-Acid Induced Aerodigestive Epithelial Barrier Disruption[J]. Laryngoscope. 2022, 132(12): 2327-2334. doi:10.1002/lary.30087 [111] Xu XH, Lv HJ, Yu L, et al. A stepwise protocol for the treatment of refractory gastroesophageal reflux-induced chronic cough[J]. J Thorac Dis, 2016, 8(1): 178-185. doi:10.3978/j.issn.2072-1439.2016.01.50 [112] Meng ZW, Lou SS, Tan J, et al. Nuclear factor-kappa B inhibition can enhance apoptosis of differentiated thyroid cancer cells induced by 131I[J]. PLoS One, 2012, 7(3): e33597. doi:10.1371/journal.pone.0033597 [113] Van WC. Nuclear factor-kappaB in development, prevention, and therapy of cancer[J]. Clin Cancer Res, 2007, 13(4): 1076-1082. doi:10.1158/1078-0432.CCR-06-2221 [114] LoTempio MM, Veena MS, Steele HL, et al. Curcumin suppresses growth of head and neck squamous cell carcinoma[J]. Clin Cancer Res. 2005, 11(19 Pt 1): 6994-7002. doi:10.1158/1078-0432.CCR-05-0301 [115] Shaker R, Babaei A, Naini SR. Prevention of esophagopharyngeal reflux by augmenting the upper esophageal sphincter pressure barrier[J]. Laryngoscope, 2014, 124(10): 2268-2274. doi:10.1002/lary.24735 [116] Yadlapati R, Craft J, Adkins CJ, et al. The upper esophageal sphincter assist device is associated with symptom response in reflux-associated laryngeal symptoms[J]. Clin Gastroenterol Hepatol, 2018, 16(10): 1670-1672. doi:10.1016/j.cgh.2018.01.031 [117] Yadlapati R, Pandolfino JE, Greytak M, et al. Upper Esophageal Sphincter Compression Device as an Adjunct to Proton Pump Inhibition for Laryngopharyngeal Reflux[J]. Dig Dis Sci. 2022, 67(7): 3045-3054. doi:10.1007/s10620-021-07172-2 [118] Sidwa F, Moore AL, Alligood E, Fisichella PM. Surgical Treatment of Extraesophageal Manifestations of Gastroesophageal Reflux Disease[J]. World J Surg. 2017, 41(10): 2566-2571. doi:10.1007/s00268-017-4058-8 [119] Weber B, Portnoy JE, Castellanos A, et al. Efficacy of anti-reflux surgery on refractory laryngopharyngeal reflux disease in professional voice users: a pilot study[J]. J Voice, 2014, 28(4): 492-500. doi:10.1016/j.jvoice.2013.12.009 [120] Wu W, Li LY, Qu CM, et al. Reflux finding score is associated with gastroesophageal flap valve status in patients with laryngopharyngeal reflux disease: a retrospective study[J]. Sci Rep, 2019, 9(1): 15744. doi:10.1038/s41598-019-52349-5 [121] Lechien JR, Dapri G, Dequanter D, et al. Surgical Treatment for Laryngopharyngeal Reflux Disease: A Systematic Review[J]. JAMA Otolaryngol Head Neck Surg, 2019, 145(7): 655-666. doi:10.1001/jamaoto.2019.0315 [122] Ward MA, Ebrahim A, Kopita J, et al. Magnetic sphincter augmentation is an effective treatment for atypical symptoms caused by gastroesophageal reflux disease[J]. Surg Endosc, 2020, 34(11): 4909-4915. doi:10.1007/s00464-019-07278-9 [123] Chandan S, Mohan BP, Khan SR, et al. Clinical efficacy and safety of magnetic sphincter augmentation(MSA)and transoral incisionless fundoplication(TIF2)in refractory gastroesophageal reflux disease(GERD): a systematic review and meta-analysis[J]. Endosc Int Open, 2021, 9(4): 583-598. doi:10.1055/a-1352-2944 [124] Snow GE, Dbouk M, Akst LM, et al. Response of Laryngopharyngeal Symptoms to Transoral Incisionless Fundoplication in Patients with Refractory Proven Gastroesophageal Reflux[J]. Ann Otol Rhinol Laryngol, 2022, 131(6): 662-670. doi:10.1177/00034894211037414 [125] 中国医疗保健国际交流促进会胃食管反流病学分会胃食管反流病射频治疗专家协作组. 中国胃食管反流病射频治疗专家建议[J]. 中华消化杂志, 2024, 44(7): 453-460. doi:10.3760/cma.j.cn311367-20240430-00174 Expert Collaborative Group on Radiofrequency Therapy for Gastroesophageal Reflux Disease, Gastroesophageal Reflux Disease Branch, China International Exchange and Promotive Association for Medical and Health Care. Chinese expert suggestion on radiofrequency therapy for gastroesophageal reflux disease[J]. Chin J Dig, 2024, 44(7): 453-460. doi:10.3760/cma.j.cn311367-20240430-00174 [126] Gao X, Wang ZG, Wu JM, et al. Radiofrequency treatment on respiratory symptoms due to gastroesophageal reflux disease[J]. Chin Med J, 2011, 124(7): 1006-1009. [127] Sui X, Deng C, Wang L, et al. Medium-term clinical efficacy of endoscopic antireflux mucosectomy on laryngopharyngeal reflux: a retrospective multicenter cohort study[J]. Gastrointest Endosc. 2023, 98(6): 893-900. doi:10.1016/j.gie.2023.07.001 |
| [1] | LI Gui, YANG Yanli, LI Donghai, YAN Xiuying. Adult orbital xanthogranulomatous disease with clinicopathological analysis report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 80-85. |
| [2] | PENG Yuting, LI Jianhao, WANG Yan. Orbital apex syndrome secondary to nasal-orbital-skull base malignant tumor: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 105-111. |
| [3] | CHEN Haiyan, WANG Ping. Easily misdiagnosed posterior scleritis:a case and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 126-130. |
| [4] | ZHU Lang, LIU Zhiqi. Utilization of real-world data from mobile health applications in therapeutic interventions for allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(4): 135-139. |
| [5] | ZHOU Yuhong, DENG Yingping. Progress of corneal collagen cross-linking for the treatment of thin keratoconic corneas [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(1): 115-121. |
| [6] | WANG Lei, LI Baowei, WANG Gang, LIU Hongdan, HAN Haolun, ZHANG Xiaoli, WU Wei. A preliminary study on nocturnal alkali reflux in OSAHS patients [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 75-79. |
| [7] | ZHANG Yuhuan, ZHANG Junbo, YIN Guoping, YUAN Xuemei, CAO Xin, SUN Yu, CHEN Qiang, YE Jingying. Comparative analysis of polysomnography parameters between the first and second halves of the night in snoring patients [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 112-117. |
| [8] | ZONG Chunlin, LU Jinbiao, YANG Yong, SU Zhongping, YU Bo. Application study of the MDT module combined with a flipped classroom in clinical teaching of pediatric OSA [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(6): 139-144. |
| [9] | XU Cong, LU Guowei, LÜ Yongbin, LIU Dawei, SONG Xicheng, SUN Yan. Intracranial pneumatosis caused by peritonsillar abscess incisional drainage: a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 63-67. |
| [10] | ZHOU Xiaoqing, YAN Yajie, LI Yingchun. Treatment of hoarseness based on physiological function of the liver [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 74-79. |
| [11] | ZHANG Xiaohan, WEI Li, YANG Kaili, CHEN Haiyan, LI Yansong, WANG Ping. Study on the change of OCTA and its correlation with visual acuity in patients with CSC before and after TCM syndrome differentiation and treatment [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 115-122. |
| [12] | ZHAO Hui, HUANG Chao, CUI Wenxuan, SI Mingwei, YANG Mengyao, WANG Hong, ZHOU Fang. Retinal artery occlusion during treatment of primary vitreoretinal lymphoma:a case report and literature review [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 123-127. |
| [13] | JIN Jing, LENG Hui. Progress in treatment of olfactory dysfunction following SARS-Cov-2 [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 162-174. |
| [14] | ZHANG Kunyi, XIAO Xuping. Research progress in the clinical treatment and drug regimen for patients with pregnancy rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 175-183. |
| [15] | QIN Nian, XIAO Yu, ZHANG Kunyi, LI Jingkun, XIAO Xuping. Application of metagenomic next-generation sequencing in cervical necrotizing fasciitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 192-197. |
|
||