Abstract: Objective To study the clinical characteristics and comprehensive management of rhino-orbital cerebral mucormycosis. Methods A retrospective analysis of the clinical data of patients with rhino-orbital cerebral mucormycosis was performed, summarising the clinical features, diagnosis and treatment methods. Results Postoperative bacterial and fungal cultures suggested methicillin-resistant Staphylococcus epidermidis and filamentous fungal infection. Linezolide and voriconazole were not effective in treating the disease. After a repeat fungal culture, the patient was considered to have a Mucor infection and was treated with isavuconazole. After 6 months of follow-up, the swelling and pain in the left orbital area had disappeared and the left eyelid elevation function had fully recovered. However, vision did not improve. Conclusion The specific type of filamentous fungal infection of the nasal cavity and sinuses is sometimes difficult to identify and requires repeated testing. Early identification of the type of fungal infection can save valuable time in the comprehensive treatment of this disease. Rhino-orbital cerebral mucormycosis progresses rapidly, and timely surgical intervention and antifungal treatment of mucormycosis can effectively control the progression of the disease.

Key words: Mucormycosis, Sinus disease, Intraorbital complications, Endoscopic surgery, Comprehensive treatment