Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2025, Vol. 39 ›› Issue (4): 108-113.doi: 10.6040/j.issn.1673-3770.0.2024.382

• Research Progress • Previous Articles     Next Articles

The role and significance of the skull base fascial tissue barrier in endoscopic resection of locally early recurrent nasopharyngeal carcinoma

WU Jiarong, QIU Qianhui   

  1. Department of Otorhinolaryngology & Head and Neck Surgery, Guangdong Provincial People's Hospital (Guanadong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China
  • Online:2025-07-20 Published:2025-08-11

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Abstract: Historically, the standard management of recurrent nasopharyngeal carcinoma(rNPC)involved two cycles of radiotherapy. However, the efficacy of the second cycle was suboptimal, resulting in a 5-year survival rate that fell below expectations and severe side effects, including radionecrosis, multiple cranial nerve deficits, and nasopharyngeal hemorrhage. These complications significantly impaired patients' quality of life and, in some cases, led to fatal outcomes.Recently, advancements in surgical techniques have emerged, offering a novel approach to managing rT1-rT3 recurrent nasopharyngeal carcinoma. For early-stage rNPC patients with rT1-rT3 tumors located in the midline area, the ability of endoscopic surgery to achieve complete tumor resection and R0 status is critical for their prognosis. The skull base fascial tissue, an integral connective tissue on the surface of the skull base, plays a crucial role. It adheres to the superficial aspect of the skull base muscles and the deep aspect of the mucous membranes. Its dense structure and strategic location provide a natural barrier against malignant tumors.Consequently, examining the clinical significance of the skull base fascial tissue in determining the extent of nasopharyngeal surgical resection can enhance clinical diagnostics and therapeutic strategies. This paper reviews the structural characteristics of the skull base fascia and its role and significance in resisting tumor invasion during early rNPC nasopharyngeal resection, highlighting its potential to improve clinical guidance in the management of this disease.

Key words: Nasopharyngeal carcinoma, Skull base, Fascia, Endoscopic surgery, Nasopharyngectomy

CLC Number: 

  • R766
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