JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2010, Vol. 24 ›› Issue (2): 26-29.

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 Expressions of SOCS3 and Eotaxin-2 in allergic rhinitis

WANG Xinlong1， ZHAO Jiandong2   

  1. 1.  School of Medicine，Shandong University，Jinan 250012，China；
     2. Department of Otolaryngology，Second Affiliated Hospital，Shandong University，Jinan 250033，China
  • Received:2010-03-09 Revised:2010-03-24 Online:2010-04-16 Published:2010-04-16

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Abstract:

Objective  To investigate expressions of SOCS3 and Eotaxin-2 in allergic rhinitis(AR)． Methods  Twenty cases of allergic rhinitis nasal mucosa tissues served as the experimental group and fifteen cases of deflection of nasal septum nasal mucosa tissues as the control group．Immunohistochemisty was performed to detect expressions of SOCS3 and Eotaxin-2．The relationship between SOCS3 and Eotaxin-2 expressions was analyzed．Results  SOCS3 and Eotaxin-2 expressions were increased in the AR patients．There were positive staining in inflammatory cells, vascular endothelial cells，epithelial cells and glandular epithelium cells．Compared with the control group，expressions of SOCS3(0.2401±0.01463) and of Eotaxin-2(0.2398±0.01423) significantly higher than those in the control group(P<0.01). The SOCS3 expression was closely related to Eotaxin-2 expression(r=0.951,P<0.01).      Conclusion  Increased expressions of SOCS3 and Eotaxin-2 in allergic rhinitis are well evidenced. SOCS3 shows positive correlation with Eotaxin-2.

Key words: Rhinitis， allergic； SOCS3； Eotaxin-2

CLC Number: 

  • R765．21
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