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24 August 2007 Volume 21 Issue 4
Articles
Plasma radio-frequency ablation in treatment of obstructive sleep apnea hypopnea syndrome
MENG Da-wei,MA Yun-peng,BAO Ji-min,LI Zhe
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 294-296 .
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Objective： To investigate the clinical effect of plasma radio-frequency in treatment of obstructive sleep apnea hypopnea syndrome(OSAHS). Method: Thirty-eight cases of OSAHS were treated by plasma radio-frequency ablation and the clinical data of these cases were also retrospectively analyzed. Results：The operation time was 8-15min, hemorrhage was 2-15ml. At post-operative 6 months, 56% cases had an effect, 41% had an improvement, and 3% had no effect, and the total effective rate was 97%. At post-operative 12 months, 53% had an effect, 38% had an improvement, and 9% had no effect, and the total effective rate was 91%. The longest time of apnea, the longest time of hypopnea, the lowest SaO2 and apnea-hypopnea index were statistically significant before and after operation, but there was not a significantly different between post-operative 6 and 12 months. Conclusion： Plasma radio-frequency ablation is convenient, simple and safe for obstructive sleep apnea hypopnea syndrome.
Hard palate shortening combined with uvulopalatopharyngolasty in the treatment of obstructive sleep apnea syndrome
WU Hao,DING Xiao-jun,ZHOU Wei-rong,LU Jun,YOU Yi-wen,NIU Guan-yi,CHENG Ya-quan
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 297-299 .
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Objective：To explore the curative effect of hard palate shortening (HPS) combined with uvulopalatopharyngolasty (UPPP) in the treatment of obstructive sleep apnea syndrome. Methods： Sixteen patients with OSAHS were subjected to HPS combined with UPPP. The pre-and post-ESS scores, polysomnography (PSG), Muller test, and cephalometric data were compared. Results：The grade of ESS, PSG and SaO2 was statistically significant (P＜0.05), and the upper airway space was obviously wider than that of the pre-operative. It was showed by Mueller′s method that the collapse degree of the pharyngeal wall was significantly decreased during inspiration. Conclusion： For OSAHS patients with an obviously narrow bony pharyngonasal and velopharyngeal cavity， HPS combined with UPPP improves not only the surgical effective power but also the curative rate.
CT imaging of upper airway stricture at the lingual region of obstructive sleep apnea hypopnea patients
LI Shu-hua,DUAN Ying-xia,SHI Hong-jin,DONG Wei-dong,ZOU Lian-gui
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 300-302 .
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Objective: To study the CT imaging of upper airway at the lingual region stricture for obstructive sleep apnea hypopnea (OSAHS) patients and to explore its meaning. Methods: One hundred patients with OSAHS were enrolled in this study and divided into two groups :the stricture group (24 cases) and the non-stricture group (76 cases). The dimension of the lingual region airway, the thickness of the retro-pharyngeal and the lateral pharyngealtissue， and the width and length of the tongue were determined. Results: There was no difference of age, BMI, AHI and pulse oxygen between the stricture group and the non-stricture group. The coronal and the arrow diameters of the stricture group were less than those of the non-stricture group. The thickness of the retropharyngeal and lateral pharyngeal wall, and the width and length of the tongue of the stricture group were larger than those of the non-stricture group. Conclusion: Lingual region stricture occurs in about 24% of patients with OSAHS, which may be caused by the incrassation of the retropharyngeal and lateral pharyngeal wall and fleshy tongue.
Peri-operative treatment of patients with severe obstructive sleep apnea hypopnea syndrome
ZHANG Qing-quan,ZHANG Hua,WANG Kun,SONG Xi-cheng,SUN Yan,WANG You-fu,WANG Qiang,LU¨ Qiao-ying
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 303-306 .
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Objective: To explore the peri-operative treatment of patients with severe obstructive sleep apnea hypopnea syndrome(OSAHS). Method: The data of peri-operative treatment of 452 patients with severe OSAHS receiving general anesthesia surgery from July 1994 to April 2006 were retrospectively analyzed. Result: 356 patients suffered from temporary velopharyngeal inadequacy and recovered 7 to 30 days later, 27 suffered from primary hemorrhage and 11 suffered from secondary hemorrhage. Conclusion: Peri-operative treatment, in addition to medicine, positive airway pressure therapy or tracheotomy and peri-control of sleep and blood pressure are all beneficial for patients with severe OSAHS.
Pharyngeal side effects following uvulopalatopharyngoplasty in patients with obstructive sleep apnea hypopnea syndrome
XU Fu-jie,LU Ai-jun
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 307-308 .
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Objective： To evaluate the incidence of pharyngeal xeransis and pharyngeal paraesthesia following uvulopalatopharyngoplasty(UPPP) in patients with obstructive sleep apnea syndrome (OSAS). Method： Fifty-two patients were subjected to UPPP and followed up. Questionnaires were used to compare the incidence of pharyngeal xeransis and pharyngeal paraesthesia between them and healthy controls. Results： During a 5-year follow-up, 16 of the 46 patients excluding diabetics had pharyngeal xeransis and 22 had pharyngeal paraesthesia. In the control group, 12 had pharyngeal xeransis and 12 had pharyngeal paraesthesia. There was a significant difference between the two groups. Conclusions： Pharyngeal xeransis and pharyngeal paraesthesia are more common in patients after UPPP than in healthy adults, which may be a result of wound excitation and cicatricle concrescence. The timbre is possibly not changed.
Excision of the huge vocal cord polyp under electronic laryngoscopy
HUANG Yi-deng,XIA Si-wen,HUANG Zi-xi,MA Qiong-fan,HU Xian-hui
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 309-311 .
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Objective: To explore the effect of the excision of the huge vocal cord polyp by an electronic laryngoscope. Method: Ten cases, of which three cases suffered from dyspnes in degree I were subjected to excision of the huge vocal cord polyp with an electronic laryngoscope under local anesthesia. Results: Eight cases were cured by one operation and two cases by two operations. No complications were found. All patients had a normal voice by vocal evaluation and vocal acoustic parameter analysis at post-operative three months. Conclusion: It is feasible to excise the huge vocal cord polyp with an electronic laryngoscope. For it, sufficient surgical skills, local anesthesia, and preparations of tracheotomy are necessary.
Pathological changes of the nasal mucosa of guinea pigs with allergic rhinitis
JI Xiao-bin,DU Hong,ZANG Lin-quan,LI Wen,XIE Jun,WANG Lei
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 312-315 .
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Objective： To investigate the pathological changes of the nasal mucosa in guinea pigs with allergic rhinitis. Methods： Toluene 2, 4-diisocyanate was mixed with florence oil in a concentration of 10% and this solution was dripped into the nostrils to induce a sensitization process. Eight guinea pigs were established with allergic rhinitis by this solution and another 8 were used as controls. Nasal mucosa tissues were observed under a light microscope. Results： False multiple coat cilium columnar epithelial cells of the nasal mucosa in the control group were found successive, intact and distinct. Normal mucosal epithelium, lamina propria and submucosa were also found in the control group. However, in the experimental group mucosal epithelium was damaged and shed, goblet cells were proliferated, squamose metaplasm and epithelial necrosis occurred, serous glands in the lamina propria were vigorously proliferated, blood vessels were expanded, tissue edema was formed, and plenty of inflammatory cells such as eosinophil and mast cells were present in great number and infiltrated, which were all roughly identical to the clinical manifestations of allergic rhinitis. Conclusion： The nasal mucosa in allergic rhinitis has characteristics of inflammatory pathological changes.
Expression and distribution of aquaporin1 in nasal polyps
YAO Li,LI Xue-pei,LIU Ping-ping,ZHENG Shi-xin,LIU Feng-an
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 316-319 .
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Objective: To explore the expression and distribution of aquaporin1(AQP1) in the formation and development of nasal polyps.Methods: Thirty cases of normal inferior turbinates and sixty cases of nasal polyps were enrolled in this study. In the nasal polyp group, there were 10 cases of type II phase 1, 15 cases of type II phase 2, 25 cases of type II phase 3, and 10 cases of type III. Expression of AQP1 in both groups was determined by the Elivision plus immunohistochemistry technique. Results: (1) Positive AQP1 cells in the epithelial cell layer of nasal polyps were significantly fewer than those of the inferior turbinate (P＜0.01) and positive AQP1 cells of nasal polyps of the type Ⅱ phase 1 were significantly more than those of the type Ⅲ or type Ⅱ phase 3 (P＜0.01). (2) Positive AQP1 cells in both the vessel endothelium and the glandular epithelium from the type Ⅲ, type Ⅱ phase 3 of nasal polyps were significantly more than those from the type Ⅱ phase 1 nasal polyps and the inferior turbinate (P＜0.01). Conclusion: AQP1 might play an important role in the formation and development of nasal polyps. Exploration of the regulation of AQP1 contributes toward evaluating the pathogenesis of nasal polyps.
Effects of reducing nasal airflow on wound healing after endoscopic sinus surgery
YUE Li-hua,JIANG Zhi-yi,LIN Gong-biao,CHENG Jin-mei,YI Zi-xiang
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 320-322 .
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Objective： To study the effects of reducing nasal airflow by placing a cotton ball in the anterior nostrils on wound healing after endoscopic sinus surgery. Methods： Among 192 patients treated with functional endoscpic sinus surgery, 30 patients who received a cotton ball placed in the anterior nostrils after removing the nasal stents were put in group A. Another 30 patients who did not receive a cotton ball placed in the anterior nostrils after removing the nasal stents in the same period were put in group B. The nasal endoscopic recordings at week 1, 2, 4 and 12 after endoscopic sinus surgery were analyzed. Results： Nasal crusts in group A were obviously fewer than in group B at week 4 after surgery. At week 12, the mucosal edema and cyst formation of the nasal cavity in group A were less than in group B. There were 11 cases with mild adhesions in group A and 22 cases with mild adhesions and 2 cases with severe adhesions in group B. Differences between the two groups were significant (P＜0.05). Patients with severe nasal crusts at week 4 after surgery had more severe adhesions, mucosal edema and cyst formation in the nasal cavity at week 12. Conclusions：Anterior nostril cotton placement after removing nasal stents is a simple and effective method to reduce nasal crust formation, which is a benefit to surgical wound healing for patients after endoscopic sinus surgery.
Endoscopic sinus surgery for inverted papilloma of the nasal cavity and paranasal sinuses
ZHANG De-zhang,LI Zhi-ru,DI Jie-yan
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 323-324 .
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Objective: To explore the effect of endoscopic sinus surgery for inverted papilloma of the nasal cavity and paranasal sinuses. Method: 18 patients with inverted papilloma of the nasal cavity and paranosal sinuses were operated on by endoscopic sinus surgery. Result: During a follow-up of 1-4.5 years only one recurred. Conclusion: Endoscopic sinus surgery has advantages of clear field and little injury and therefore it is effective for inverted papilloma of the nasal cavity.
Management of adult obstinate epistaxis by endoscopy
LIAN Zhuang,ZHANG Pan
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 325-326 .
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Objective: To explore the sites of adult obstinate epistaxis and investigate an effective and minimally invasive management for hemostasis under endoscopy. Method: Bleeding points were searched for and treated by electro-coagulation under an endoscope. Result: Bleeding was found in the olfactory cleft of the nasal septum and the top nasal septum in 68 cases (52.7%), at the superior wall of the inferior meatus in 37cases (28.7%), undernearth the sphenoethmoidal recess in 10 cases (7.8%), in the Little′s area in 8 cases (6.2%), in the posterosuperior area of the nasal septum in 5 cases (3.9%) and was indefinite in 1 case. Conclusion： Almost all bleeding points of adult obstinate epistaxis cases can be found under endoscopy and they are mainly distributed in the olfactory cleft of the nasal septum and the top nasal septum, or at the superior wall of the inferior meatus. Electro-coagulation under endoscopy is an effective and minimally invasive management for adult obstinate epistaxis.
Related-factors of the prognosis of epistaxis
HUANG Min-qi,GUO Zhen-ping
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 327-328 .
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Objective: To explore the factors relating to the prospective effect of epistaxis. Method: The clinical data of 126 cases with epistaxis were retrospectively analyzed. Result: Age, disease process, hypertension, psychological condition and Luohuazizhu tablets were all related to the prognosis of epistaxis. Conclusion: Drug therapy combined with Louhuazizhu tablets for three days and psychological leading are effective on epistaxis.
Septorhinoplasty with reservation of the cartilage
YIN Guo-hua,ZHONG Xiao
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 329-331 .
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Objective: To explore a way of reserving the cartilage in nostril septum surgery. Method: Based on different types of the deflection of the nasal septum, three operative procedures (A, B and C) were designed in 156 cases. Results: The operative period was shortened and the bleeding was decreased. During a follow-up of one to six months, no complications occurred. Conclusions: Septorhinoplasty with reserving of the cartilage of the nasal septum is more micro-invasive with the advantages of small injury, little bleeding and short operative time.
Radio-frequency and stryker instruments under nasal endoscopy for 68 cases of adenoidal hypertrophy
XIAO Lu,LIAN Zhuang,ZHANG Pan,LEI Da-peng
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 332-333 .
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Objective: To investigate the curative effect of radio-frequency and stryker instruments under nasal endoscopy on adenoidal hypertrophy in children. Methods: 68 patients with adenoidal hypertrophy were treated by radio-frequency combined with stryker instruments under nasal endoscopy. Results: 63 cases were cured and 5 cases were improved. Conclusion: Radio-frequency combined with stryker instruments under nasal endoscopy has advantages of clear view, minimal invasion, safety and effectiveness for adenoidal hypertrophy.
Correlation between skill and relapse in endoscopic sinus surgery
LIANG Hong-min,LI Yong-li,GUO Qing-bao
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 334-335 .
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Objective: To study the correlation between skill and relapse in endoscopic sinus surgery. Method: Relapse induced by improper operative procedures from 2001 to 2005 in our hospital was retrospectively analyzed. Result: Factors of relapse were as follows: the exalted deviation of nasal septum was not remedied; the focus between the egger nasi and the frontal recess was not completely operated on; the ethmoid sinus was not completely opened; the middle turbinate was improperly operated on; the uncinate process was hung over; the ostium maxillary was narrow; polyp in the maxillary sinus was not completely removed; the nasal mucosa stuck together; hypertrophy of the inferior turbinate was not operated on. Conclusion: Great knowledge of anatomy and operative skill and proper treatment of the easily recurrent focus are important to avoid relapse.
Treatment for adhesion following nasal endoscopy in chronic sinusitis
WEI Fu-yi,QIN Wen-ge,QIN Qi-cai,SU Xing-gui,YAO Zhi-yuan,YANG Kai-yan,LI Shu-zheng
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 336-337 .
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Objective: To investigate the effects of different managements on nostril adhesion after nasal endoscopy. Methods: A total of 340 patients were randomly divided into two groups: Mitomycin was locally applied to 160 cases (308 sides) in the treatment group and not used for 180 patients (346 sides) in the control group. All were given Rhinocor and routine irrigation to nostrils after surgery. Result: The prevalence of adhesion and the curative rate were significantly different between the two groups. Conclusion: Local application of Mitomycin following nasal endoscopy can significantly reduce adhesion in nostrils and raise the curative rate of chronic sinusitis.
Transnasal endoscopic management for hidden severe epistaxis
LOU Zheng-cai
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 338-340 .
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Objective: To explore the effect of endoscopy for hidden severe epistaxis. Methods: One hundred and six patients were examined by endoscopy and treated by selectively minimum invasive surgery. Results: The bleeding points were discovered by one examination in 93 cases （87.74%）, by two treatments of the nasal anomalous structure and nasal diseases in 11 cases （10.37%）, and were uncertain in 2 cases（1.89%）. Ninety cases(84.91% ) were cured by one treatment, 14 cases(13.20% ) by two and 2 cases by three. There was no relapse during a followedup for 3 months after management. One case had nasal septum perforation. Conclusion: Refractory epistaxis should be individually treated: first to be found and second to be treated under endoscopy.
Curative effect of cocal cord surgical treatment with a suspension micro-laryngoscope under general anesthesia:a report of 135 cases
ZHAO Ya-ming,GU Neng-rong,ZHANG Gui-juan
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 341-342 .
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Objective: To investigate the clinical curative efficacy of micro-laryngoscopic surgery on polyps, nodules, leukoplakia and cysts of the vocal cords with a suspension micro-laryngoscope under general anesthesia. Methods: The clinical data of 135 cases from 1999 to 2001 in our hospital were reviewed and analyzed. All received laryngoscopic examination before the surgery and regular pathologic determination after the surgery. All cases were followed up for half a year to 7 years. Results: Among 121 cases of vocal cord polyps, 118 cases recovered pronunciation within 2 weeks and 3 cases recovered less well due to a large trauma. No nodules, leukoplakia and cysts of the vocal cords relapsed within half a year in the following up. The success rate was 97.78%. Conclusion: Surgery for localized pathological changes with a suspension laryngoscope under general anesthesia is a safe and reliable treatment with a low rate of relapse.
Endoscopic surgery and premanagement implantation of a place holder for osteoma of the frontal sinus
LI Zhi-shen,LI Jing,GONG Li-li
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 343-345 .
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Objective: To explore the clinical value of the supraorbital keyhole approach for removing frontal sinus osteoma with permanent implantation of a place holder by nasal endoscopy. Methods： The supraorbital keyhole approach operation with permanent implantation of a place holder by nasal endoscopy was performed on 18 patients with frontal sinus osteoma from 1.2001 to 6.2005. Implantations were kept for 1 to 3 months. Results: All were cured without relapse and complications. Conclusion: This way is method with a clear operative area, minimally invasive, little blood loss, well drainage and no operative scars left on the face.
Correlation between chronic cough and postnasal drip syndrome in children
LI Shu-jie,ZHANG Feng,GAO Zhen-feng,LU¨ Ling-yan,WU Yu-mei
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 346-348 .
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Objective: To explore the correlation between chronic cough and postnasal drip syndrome(PNDS) in children. Method: A retrospective study was carried out among 75 cases of postnasal drip syndrome. Results: Chronic cough was the main complaint but no obvious lesions were found in the throat, trachea and branches, however, definite lesions were determined in the nasal cavity and/or paranasal sinuses including chronic rhinitis, nasosinusitis, allergic rhinitis and adenoiditis. 30 cases were misdiagnosed as repetitive respiratory infection, bronchitis, variant asthma, foreign bodies in the respiratory tract, or pneumonia, and in 13 cases a diagnosis was missed. Conclusion: Postnasal drip syndrome can be cured following effective treatment.
Non-epithelial tumor of the nose and nasal sinus in 9 cases
XIAN De-sheng,SU Bing-ze,ZHOU Xue-jun,HUANG Ji-hong,WANG Hai-mei
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 349-351 .
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Objective: To improve diagnotic ability of nonepithelial tumor in nostrils and nasal sinuses.Method: The clinical data of 9 cases of nonepithelial tumor of nostrils and nasal sinuses were retrospectively analyzed. Result: 5 cases died,1 case relapsed and the other 3 cases did not relapse after 1 to 3 years. Conclusion: The clinical features of nonepithelial tumor of the nose and nasal sinuses are not typical. Besides imaging and histopathology, immunohistochemistry is also important for diagnosis.
Objective acoustic analysis of the voice in early glottic laryngeal carcinoma following laser surgery
ZHU Zhao-feng,WANG Yue-jian, LIANG Yu-yan, CHEN Wei-xiong,CHEN Rui-kai
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 352-354 .
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Objective: To explore voice restoration of patients with glottic laryngeal carcinoma after laser surgery. Method: A computer vocal acoustics test system (Dr.speech for Windows) was used to determine the voice quality of 66 patients with glottic laryngeal carcinoma. Results: The value of jtter was not changed a lot, but the value of shimmer NNE was decreased at 3 months after surgery and the voice quality was significantly improved at 6 months after surgery and then in a steady state for typeⅡcompared with those for other types(P＜0.01). Voice quality was improved in type Ⅲ at 6 months after surgery compared with that in types Ⅳ and Ⅴ (P＜0.05) and it was not improved in types Ⅳ and Ⅴ at 1 year after surgery. Conclusion: Recovery time and quality are different in different types of laser surgery. The surgical range is closely related to the recovery of laryngeal structure and voice function.
A comparative study on two surgical techniques for benign parotid tumors
ZHANG Jia-xiong,XIAO Qin,WEI Ming,ZHOU Wen-ru,TANG Ya-nan,PANG Ling,ZOU Wen-tao,ZHU Yu-fang
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 355-356 .
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Objective: To evaluate the results of superficial parotidectomy and regional resection both with preservation of the Steven′s duct. Methods： 20 cases were subjected to superficial parotidectomy and 11 cases to regional resection both with preservation of the Steven′s duct. Complications and treatment outcomes were analyzed. Result: The results of regional resection are better than those of superficial parotidectomy. Conclusion: Regional resection with preservation of the Steven′s duct is a possible alternative for some patients, especially those with benign parotid tumor.
C-reactive protein level of patients with head and neck tumor before operation
CHEN Zhi-jun,MU Ying-xin,WANG Ping
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 357-359 .
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Objective： To investigate the relationship of C-reactive protein(CRP) level of patients with head and neck tumor before operation and the infection after operation. Methods: The content of CRP, ABL and WBC in 177 patients with head and neck tumor preoperative 1day was determined. The data of C-reactive protein and infection after operation were analyzed by a statistical method. Results: Twentyone patients (11.9%) had infection after operation, whose CRP level was much higher than patients without infection (t=2.835，P＜0.01)．The infection rate of patients with an increased CRP level was significant higher than that with a normal CRP level (χ2=6.18,P＜0.01). Moreover, the admission period was obviously prolonged (t=2.215，P＜0.05)．Conclusion: As the serum CRP is raised in patients with head and neck tumor before operation, the infection risk significantly increases after operation.
Effect of Paclitaxel on the hearing threshold in guinea pigs
JIANG Yi,LI Rui-yu,CHEN Yong
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 360-361 .
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Objective: To investigate the effects of Paclitaxel on the hearing threshold in guinea pigs. Methods: Thirty female guinea pigs were randomly divided into one control group and five experimental groups. The control group received no medications while the five experimental groups were intraperitoneallly subjected with different doses of Paclitaxel. Prior to medication and after the ending of medication, all animals underwent auditory brainstem response (ABR) testing bilaterally. Results: Hearing levels were significantly decreased in the experimental groups. No correlation was found between the dose given and the degree of hearing loss. Conclusion: Paclitaxel causes mild to moderate sensorineural hearing loss.
Perforation of the tympanic membrane in 256 cases
WU Liu-qing,LIU Hong-qi,TANG Xiang-rong,LIANG Zhi-cheng
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 362-363 .
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Objective: To explore the clinical features of perforation of the tympanic membrane and to discuss factors relating to patient condition. Method: The clinical data of 265 cases in hospital from 1996 to 2006 were retrospectively analyzed. Results: Indirect damages were more than direct damages and they were mainly located in the intense position in 239 cases. 246 cases had conductive deafness and 28 had complications of vertigo, facial paralysis of concussion of the brain. After treatment, 244 cases were cured and others had permanent deafness and other symptoms. Conclusion: Each kind of flesh wound may cause not only perforation of the tympanic membrane, but also damage to the middle ear, the internal ear and even the brain. The degree, promptness and comprehensive treatment, condition of ear trouble and the whole body are all closely related to restoration and prognosis.
Cervical necrotizing fasciitis: a clinical report of 6 cases
SU Kai-ming,YIN Shan-kai,LU Wen-ying,ZHANG Yu-jun,TANG Xu-lan,ZHU Hua-ming
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 364-367 .
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Objective: To improve the acknowledgement of surgeons on cervical necrotizing fasciitis. Methods: Six cases of cervical necrotizing fasciitis were treated in our hospital from 1999 to 2006 and the clinical data were retrospectively analyzed. Results: All the patients were treated with active surgical debridement and medical therapy. Five cases were cured and one case died due to severe complications including sepsis and multiple organ failure. Conclusion: Necrotizing fasciitis of the neck is a rapidly progressive soft tissue infection with high morality. Successful treatment of this disease consists of radical surgical debridement as early as possible, broad-spectrum of antibiotics and supportive therapy.
Reconstruction of the palatal defect by folding radialis forearm free flap
CHEN Xu-bing,HU Wei
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2007, 21(4): 368-369 .
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Objective： To explore the repair method of maxilla and palate defects by folding radialis forearm free flaps. Method: The clinical data of 4 cases of the folding radialis forearm free flaps for instant maxilla and palate reconstruction were retrospectively analyzed. Result: All the forearm free flaps were well healed. The oral cavity was completely parted from the nasal cavity, which helped to maintain adequate phonation and swallowing function. The outline form of the face and palate was satisfactorily restored. Conclusion: The folding radialis forearm free flap is effective and it is the first choice in repairing maxilla and palate defects.
