JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

• Articles • Previous Articles     Next Articles

Pathological changes of the nasal mucosa of guinea pigs with allergic rhinitis

JI Xiao-bin1,DU Hong2,ZANG Lin-quan3,LI Wen2, XIE Jun3,WANG Lei1   

  1. 1. Department of Otorhinolaryngology, Guangzhou First People′s Hospital;2. Department of Pathology, Guangzhou First People′s Hospital;3. Department of Pharmacology, School of Preclinical Medicine, Sun Yat-sen University
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24
  • Contact: JI Xiao-bin

Abstract: Objective: To investigate the pathological changes of the nasal mucosa in guinea pigs with allergic rhinitis. Methods: Toluene 2, 4-diisocyanate was mixed with florence oil in a concentration of 10% and this solution was dripped into the nostrils to induce a sensitization process. Eight guinea pigs were established with allergic rhinitis by this solution and another 8 were used as controls. Nasal mucosa tissues were observed under a light microscope. Results: False multiple coat cilium columnar epithelial cells of the nasal mucosa in the control group were found successive, intact and distinct. Normal mucosal epithelium, lamina propria and submucosa were also found in the control group. However, in the experimental group mucosal epithelium was damaged and shed, goblet cells were proliferated, squamose metaplasm and epithelial necrosis occurred, serous glands in the lamina propria were vigorously proliferated, blood vessels were expanded, tissue edema was formed, and plenty of inflammatory cells such as eosinophil and mast cells were present in great number and infiltrated, which were all roughly identical to the clinical manifestations of allergic rhinitis. Conclusion: The nasal mucosa in allergic rhinitis has characteristics of inflammatory pathological changes.

Key words: Rhinitis, allergic, Disease models, animal, Nasal mucosa, Pathology

CLC Number: 

  • R765.41
[1] WANG Tan, WU Ke, LI Lianqing, GONG Lili. Factors associated with systemic adverse reactions after subcutaneous immunotherapy injections and treatment options [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 71-74.
[2] LU Hangui, LIN Xinsheng, YAO Danmian, WEI Yongxin, LI Chuangwei. Expression of IL-35 in allergic rhinitis and its effect on the immunoregulation of T cells [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 66-70.
[3] WANG Chi, LIU Xing, KONG Lei, HONG Xinghe, NING Bo. Clinical efficacy of endoscopic plasma radiofrequency ablation in the treatment of adenoid hypertrophy and sinusitis in children and its effect on nasal mucociliary clearance [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(5): 78-81.
[4] PU Hongbo, DU Xiaodong. Allergen test results in 2 000 patients with allergic rhinitis in Wuxi District [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 105-107.
[5] BAI Yong, YIN Yingchun, HAN Xuefeng, YIN Zhaofu, LI Xuezhong. Clinical analysis of low-grade myofibroblastic sarcoma of the head and neck [J]. J Otolaryngol Ophthalmol Shandong Univ, 2018, 32(4): 58-61.
[6] WU Xiangping. Influence of patient management on the clinical effect of sublingual dermatophagoides farinae drops in patients [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 68-72.
[7] CHEN Ming, YU Xuefei. Opinions on the treatment of chronic rhinosinusitis with allergic rhinitis [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(3): 18-22.
[8] LI Song, WANG Zonggui, YANG Jingpu, ZHANG Zhuping. Progress of transnasal endoscopic vidian neurectomy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(1): 72-76.
[9] LI Chao, CAO Yonghua, ZHANG Yanting, CHENG Fengli, REN Jianjun, ZHAO Changqing. Nasal endoscopy in the treatment of nasal mucosal hyperreactive rhinopathy [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2018, 32(1): 77-81.
[10] ZHI Lili, SONG Daoliang. Expressions of eosinophils and IL5 in antrochoanal polyps and nasal polyps. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 43-46.
[11] WAN Wenjin, WANG Wen, CHENG Lei. A meta-analysis of subcutaneous immunotherapy and sublingual immunotherapy in the treatment of dust mite-allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 103-108.
[12] HU Jindong, LIU Xinquan. Research progress of dry eye animal model. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(4): 109-113.
[13] CHENG Lei, QIAN Junjun, TIAN Huiqin. Research progresses on allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 1-3.
[14] XU Yu, TAO Zezhang. Pharmacotherapeutic strategies for allergic rhinitis:Ithe importance of individualization and normalization. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 4-8.
[15] LIU Ying, YE Xiaojing, ZHAO Cunli, JI Qing, HUANG Qian. Preventive treatment for seasonal allergic rhinitis. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2017, 31(3): 37-40.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!