JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Expression and distribution of aquaporin1 in nasal polyps

YAO Li1，LI Xue-pei2，LIU Ping-ping3，ZHENG Shi-xin1， LIU Feng-an1   

  1. Department of Otolaryngology, 1. Peking University Shenzhen Hospital, Shenzhen 518036;2. Peking University Third Hospital, Beijing 100083;3. Shenzhen Second People′s Hospital, Shenzhen 518039
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-08-24 Published:2007-08-24
  • Contact: YAO Li

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Abstract: Objective: To explore the expression and distribution of aquaporin1(AQP1) in the formation and development of nasal polyps.Methods: Thirty cases of normal inferior turbinates and sixty cases of nasal polyps were enrolled in this study. In the nasal polyp group, there were 10 cases of type II phase 1, 15 cases of type II phase 2, 25 cases of type II phase 3, and 10 cases of type III. Expression of AQP1 in both groups was determined by the Elivision plus immunohistochemistry technique. Results: (1) Positive AQP1 cells in the epithelial cell layer of nasal polyps were significantly fewer than those of the inferior turbinate (P＜0.01) and positive AQP1 cells of nasal polyps of the type Ⅱ phase 1 were significantly more than those of the type Ⅲ or type Ⅱ phase 3 (P＜0.01). (2) Positive AQP1 cells in both the vessel endothelium and the glandular epithelium from the type Ⅲ, type Ⅱ phase 3 of nasal polyps were significantly more than those from the type Ⅱ phase 1 nasal polyps and the inferior turbinate (P＜0.01). Conclusion: AQP1 might play an important role in the formation and development of nasal polyps. Exploration of the regulation of AQP1 contributes toward evaluating the pathogenesis of nasal polyps.

Key words: Aquaporin1, Nasal polyps, Immunohistochemisty

CLC Number: 

  • R765.23
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