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    16 February 2014 Volume 28 Issue 1
      
    Articles
    Establishment of sensorineural deafness model in C57 mice by cisplatin
    HE Jing-chun1, RUAN Qing-wei2, HAN Miao-miao1, JIN Bin1, LI Ke-yong1, DONG Pin1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  1-5.  doi:10.6040/j.issn.1673-3770.0.2013.237
    Abstract ( 1555 )   PDF (2145KB) ( 1773 )   Save
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    Objective   To establish a cisplatin-induced sensorineural deafness model in C57 mice. Methods   C57BL/6J mice were divided randomly into four groups:group A (5μL normal saline injected into the round window niche), group B (5μLcisplatin (1mg/mL) injected into the round window niche), group C (10μL cisplatin (1mg/mL) injected daily into middle ear cavity for 5 days), and group D ( cisplatin (6mg/kg) injected daily into the abdominal cavity for 5 days). 10 dB increase or above in the reaction threshold of  whole octave band auditory brainstem response (ABR) was to define the decline of the hearing capacity. The stereocilia and cuticular plate of hair cells stained with fluorescent phalloidin were observed. Results   In group A,C and D, the whole octave band ABR reaction thresholds showed no difference before and after the administration (P>0.05). However, the reaction threshold were all elevated 48h after the administration in B group (P<0.05). Meanwhile, in group B, outer hair cell (OHC) lesions were more severe than those of inner hair cell (IHC), and the hair cells lesions aggravated gradually from the base to apex of chochlea. Conclusion   The administration of cisplatin through the window niche is the effective method to establish sensorineural deafness model in C57 mice.

    Application of double vascularized soft tissue flap in open radical mastoidectomy
    LI Shao-hua, SUN Yi-fan, LU Biao-qing
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  6-7.  doi:10.6040/j.issn.1673-3770.0.2013.024
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    Objective   To investigate the clinical application of double vascularized soft tissue flap in open radical mastoidectomy. Method   From July 2009 to June 2012, 98 otitis media patients (98ears) with cholesteatoma were treated with open radical mastoidectomy. In 52 cases (52 ears), double  vascularized soft tissue flap was tamped into mastoid cavity, while pedicled temporalis myofascial flap was applied in the other 46 cases (46 ears), as control. Result   The time to achieve a dry ear in treatment and control group were (17.07±/-1.28) days and (22.96±/- 6.21) days, respectively(P<0.05). Conclusion   Obliteration of mastoid cavity with retroauricular vascularized soft tissue flap after open radical mastoidectomy shows the following advantages: ① maximum coverage of mastoid cavity; ② rapid re-epithelization of mastoid cavity and shortened time to obatin dry ear; ③ no further mastoid cavity cleaning.

    Repair of big tympanic membrane perforation with cartilage island-perichondrium under endoscopy and microscopy
    WANG Jin
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  8-9.  doi:10.6040/j.issn.1673-3770.0.2013.257
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     Objective   To investigate the effectiveness of big tympanic membrane perforation repaired with cartilage island-perichondrium under endoscopy or microscope. Methods   Thirty  patients with big tympanic membrane perforation underwent repair under endoscopy or microscope between 2010 and 2012. The clinic data were reviewed. Results   Among the patients, 15 cases were repaired by endoscopy and the other 15 cases were repaired by microscope. After follow-up for 3 months, the cure rate in  endoscope group was 100%, with  10 normal, 4 improved, but 1 unchanged hearing. The cure rate in the microscope group was 80%, with 12  normal, 1 improved and 2 unchanged hearing. Conclusion   Repair of big tympanic membrane perforation under endoscopy is easy and  time-saving, and the injury is samll. 

    Regeneration of motor neurons induced by different concentrations of GDNF in vitro
    XIA Si-wen1,2, CHEN Shi-cai1, HUANG Yi-deng2, LI Meng1, LI Xiao-yu1, ZHENG Hong-liang1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  10-13.  doi:10.6040/j.issn.1673-3770.0.2013.286
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    Objective   To investigate the regeneration of motor neurons induced by different concentrations of glial cell line-derived neurotrophic factor(GDNF) in vitro to determine the optimal GDNF concentration. Methods   With the motor neuron regeneration model, different concentrations of GDNF were added into the chamber and the formation of a stable concentration gradient was achieved. After 72-hour cell culture, the optimal concentration of GDNF to induce the regeneration was determined by measuring the angles and lengths of growth cones on motor neurons under different concentrations. Results   For the regeneration of motor neurons, there was no significant difference between GDNF 200ng/mL group and GDNF 100ng/mL group (P>0.05), however, both groups showed better effects than the blank control group and GDNF 50ng/mL group (P<0.05).  The difference between the latter two groups was not significant (P>0.05). Conclusion    GDNF could induce the regeneration of motor neurons significantly, and the optimal concentration in vitro is 100ng/mL.

    Expression of a proliferation-inducing ligand in laryngeal squamous cell carcinoma
    WEI Xi-jian1, YIN Rui-lan2, GUO Xing3
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  14-16.  doi:10.6040/j.issn.1673-3770.0.2013.226
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    Objective   To investigate the expression of a proliferation-inducing ligand(APRIL) in laryngeal squamous cell carcinoma(LSCC). Methods   Expression of APRIL was detected in 150 laryngeal squamous cell carcinoma samples and 150 para-carcinoma tissue by SABC immunohistochermical method.  The relationship between APRIL expression and the clinical staging of LSCC was analyzed. Results   Expression of APRIL protein in para-carcinoma tissue was 6.7%(10/150)but 89.3%(134/150)in tumor tissues.The weighted scores of APRIL in different stages of LSCC were gradually and significantly increased(P<0.05), APRIL expression level was closely associated with TNM stage(P<0.05). Conclusion   These findings suggest that the APRIL expression are high in LSCC and significantly correlated with tumor staging.

    Endoscopic reconstruction of skull base in animal experiments
    ZANG Yun-peng, LIU Ting-ting, SHANG Qing-jun, YU Qian-qian, JIANG Xiao-dan, LI Shen-ling, DANG Zhi-hong, HUANG Tian-qiao, ZHANG Nian-kai
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  17-21.  doi:10.6040/j.issn.1673-3770.0.2013.256
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    Objective   To explore the impaction and significance of radiation therapy on repair of skull base defect with nasal septum mucosa flap with pedicle in rabbit models. Methods   Ten fresh white rabbit bodies served for the anatomy research of blood supply of nasal septum mucosa flap. Twenty  New Zealand white rabbits were induced into models of skull base defect and cerebrospinal fluid rhinorrhea. Nasal septum mucosa flap with pedicle was employed to reconstruct the defect and repair the leakage.  Seven  days and 10 days after the operation, wound healing and leakage were observed by nasal endoscopy. Twenty-one  days after the operation, 10 rabbits which accepted the surgical treatment as the experimental group were randomly drew to get radiation therapy, the other 10 as the control group.  One day and 14 days after the radiation therapy, repair area of the experiment and the control groups were respectively observed by nasal endoscopy. Results   Seven  blood supplies of the nasal septum mucosa flap come from behind and below the nasal septum, 2 blood supplies come from behind the nasal septum 1cm away, and 1 did not show obvious blood supply. Twenty  rabbits models of skull base defect and cerebrospinal fluid rhinorrhea and the nasal septum mucosa flap with pedicle was employed to reconstruct the defect and repair the leakage were successfully established and survived without any complication as continuous rhinorrhea of cerebrospinal fluid, local tissue eminence and neurological function defect.Ten  rabbits of the experiment group which accepted radiation therapy and 10 rabbits of the control group were all survived, but the speed of wound healing of the rabbits of the experiment group was fairly slower. Conclusion   Repair of skull base defect with the nasal septum mucosa flap with pedicle in rabbit models is feasible, and radiation therapy can delay the speed of healing of the nasal septum mucosa flap with pedicle.

    Evaluation indexes for treatment plan and curative effect evaluation in nasopharyngeal carcinoma patients with postradiotherapy chronic rhinosinusitis
    LIU Yang-yun1, CHEN Zhi-xi2, JIANG Wen1, LI Zheng-xian1, MAO Kun-hua1
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  22-26.  doi:10.6040/j.issn.1673-3770.0.2013.274
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    Objective   To investigate the value on different evaluation indexes for nasopharyngeal carcinoma patients with post-radiotherapy chronic rhinosinusitis (post RT-CRS).  Methods   Ninty-eight  post RT-CRS patients were divided into 3 groups: the expectant treatment (group 1), the maxillary natural ostium enlargement (group 2) and the combined fenestration operation(group 3) under nasal endoscopy. Visual analogue score (VAS), sinus CT lund-mackay scores, and endoscopic lund-kennedy scores before and after treatment were analyzed.  Results   Only the VAS of purulent secretion was statistically different in group 1, but the VAS of purulent secretion and facial gas pains were statistically different in groups 2 and 3, and the curative effect of group 3 was better than that of group 2. The curative effect of maxillary sinusitis and sphenoid sinusitis were unsatisfied in group 1. The good curative effect to all sinusitis was found in the groups 2 and 3, and the curative effect of group 3 was better than group 2. The sinus CT lund-mackay scores and the endoscopic lund-kennedy scores before and after treatment had no statistical difference in group 1. The statistical difference of the lund-mackay scores could been found between groups 2 and 3 before and after treatment, post-treatment in groups 2 and 3, between the expectant group and the operation groups. The endoscopic lund-kennedy scores had no statistical difference in all groups. Conclusion   ① Maxillary natural ostium enlargement in combination with  fenestration operation under nasal endoscopy is better for post RT-CRS patients with high VAS of  purulent secretion and facial gas pains. ② As to evaluation of the extent of disease before treatment and the operation effect, sinus CT lund-mackay scores is better than  other evaluation indexes.

    Comparison of curative effect between coblation inferior turbinate reduction and inferior turbinoplasty in treatment of chronic rhinitis
    XU Wen-ya, LIU Ting-ting, JIANG Xiao-dan, DANG Zhi-hong, LOU Shuai-shuai, ZHANG Nian-kai
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  27-30.  doi:10.6040/j.issn.1673-3770.0.2013.251
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    Objective   To compare the clinical effect on nasal obstruction and mucociliary function between coblation inferior turbinate reduction (CITR) and inferior turbinoplasty in treatment of chronic rhinitis and to explore which is more effective. Methods   Forty patients with chronic rhinitis were randomly divided into two groups: the CITR group and the inferior turbinoplasty group. A standard visual analog scale (VAS) was used to assess the nasal obstruction before the operation, one week, one month and three months after the treatment. A Saccharin test was used to evaluate the nasal mucocilary transportation before and 3 months after the treatment. Results   Coblation inferior turbinate reduction resulted in little intra-operative bleeding and duration and few post-operative complications. After 3 months, nasal obstruction was significantly improved in both the coblation and the control groups. The two methods made no difference on nasal mucociliary function. Conclusion   For chronic rhinitis, when the pathological changes is simply mucosal hypertrophy, and coblation inferior turbinate reduction is significant in efficiency. When there is turbinate bone hypertrophy or abnormal morphology,  inferior turbinoplasty is better in efficiency.

    Relationship between radioactive otitis media and changes in cross section area of tensor veli palatine (TVP) muscle after radiotherapy in patients with nasopharyngeal carcinoma
    YANG Jian-ming
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  31-33.  doi:10.6040/j.issn.1673-3770.0.2013.212
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    Objective   To study the relationship between radioactive otitis media and changes in cross section area of tensor veli palatine (TVP) muscle after radiotherapy in patients with nasopharyngeal carcinoma. Methods   Retrospectively analyze the clinical data of 36 patients with nasopharyngeal carcinoma who accepted radiotherapy in our hospital from January, 2007  to January, 2011. The cross section area (CSA) of TVP and medial pterygoid (MP) muscle of all the patients were measured before and after radiotherapy, meanwhile the incidence of SOM was surveyed after radiotherapy. Results   Twenty-four  cases (44 ears) developed post-irradiation SOM after the radiotherapy. STVP, SLTVP, SRTVP, SLTVPM, SRTVPM, SLTVPF, SRTVPF, SMP, SLMP and SRMP of all patients statistically decreased after radiotherapy (P<0.05). Ears with TVP atrophy had a high rate of incidence of SOM than ears without TVP atrophy (72.92% vs 37.50%, χ2=8.445, P=0.004). Conclusion   The atrophy occurs to the CSA of TVP and MP of patients with nasopharyngeal carcinoma, which may result in post-irradiation SOM.

    Prognostic significance of epithelial-mesenchymal transition state in patients with chronic sinusitis treated under endoscopy
    GUO Zhi-juan1, LI Pei-hua1, ZHANG Xiao-wen2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  34-38.  doi:10.6040/j.issn.1673-3770.0.2013.243
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    Objective   To investigate the epithelial-mesenchymal transition state (EMT) of patients with chronic sinusitis and to analyze the correlation of EMT with clinical data and symptom scores and its prognostic significance for patients. Methods   The nasal or sinus mucosa specimens of 30 patients with chronic sinusitis and 15 healthy people were collected. Real-time quantitative PCR (RT-PCR) was used to detect relative expressions of epithelial marker E-cadherin mRNA and mesenchymal marker α-SMA mRNA. Pearson was used to analyze its correlation with symptoms score. Results   Compared with the control group, the relative expression of epithelial cell marker E-cadherin mRNA decreased and α-SMA mRNA relative expression increased suggesting the existence of EMT; α-SMA mRNA expression was positively correlated with smoking, and E-cadherin mRNA expression was negatively correlated with age, disease duration and smoking (P<0.05); The correlation of sleep score, Lund-Kennedy total score, anterior ethmoid score and α-SMA mRNA expression was positive, while the correlation of nasal symptoms score, Lund-Kennedy total score, and Lund-Mackay total score and E-cadherin mRNA expression was negative(P<0.05). Conclusion   In the nasal or sinus mucosa of CRS patients without nasal polyps, EMT exists. The more severe the CRS is, the more obvious the EMT is. EMT has a certain suggestive significance for prognosis and outcome of the patients.

    Analysis of allergen spectrum among 1-12 years old children with allergic rhinitis in Beijing region
    DAI Wei-li, ZHANG Jie, ZHANG Ya-mei
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  39-45.  doi:10.6040/j.issn.1673-3770.0.2013.198
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    Objective   To investigate the inhalant allergen spectrum among 1-12 years old children with allergic rhinitis in Beijing region. Methods   A sensitive quantitative allergen screen system(Allergy Screen)and its allergen diagnosis reagent in vitro were carried out in 663 children(1-12 years old)with allergic rhinitis in BeiJing region for the sIgE of inhalant allergen. The trend of inhaled allergen positive rate in different ages was also observed. Results   ① All the patients showed positive reaction to inhalation allergen. The most common allergen found in patients was mixed fungi(61.4%), followed by house dust mite(32.6%), house dust(28.2%) and mugwort(23.8%) ect. The top three allergens of sIgE≥Ⅲ grade accounting corresponding positive cases were mugwort (70.9%, 112/158), the mixed fungi (63.9%, 260/407) and house dust mite (56.5%, 122/216). ② With the growth of age, the positive rate of mixed fungi was overall downward trend. The positive rate of household dust mites was overall upward trend. Distribution of house dust mite in groups A-D was statistically significant (χ2=17.757,P<0.001). ③ The distribution of mugwort (χ2=10.636,P=0.014), mixed fungi (χ2=8.298,P=0.040) and house dust(χ2=11.681,P=0.005) of sIgE≥Ⅲ grade in A - D groups was statistically significant. ④ The curve of the percentage of a pasture class humulus scandens and dwarf ragweed allergen sIgE≥Ⅲ grade accounted corresponding positive cases was lower than the curve of the mugwort, but higher than the curve of the woody plants tree pollen. ⑤ Patients with single positive allergen of mixed fungi were the most common,followed by dual positive allergens. The most common dual allergens combination was mixed fungi plus house dust mite. Conclusion   The primary allergen in children with allergic rhinitis in Beijing region is mixed fungi. With the growth of age, all kinds of allergens have its trend changes. The allergy strength of fall weed pollen is stronger than pasture, and pasture is stronger than woody plants tree pollen. Single positive allergen is the most common.

    Curative effect of traditional Chinese medicine in combination with western medicine on chronic sinusitis in children
    LIU-Quan, L Chuan-zhen
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  46-47.  doi:10.6040/j.issn.1673-3770.0.2013.351
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    Objective   To observe the curative effect of traditional Chinese medicine in combination with western medicine on chronic sinusitis in children. Methods   120 children with chronic sinusitis were divided at random.60 cases were treated by traditional Chinese in combination with western medicine and 60 cases were treated by western medicine as control. ResultThe general effective rate of the treatment group was 86.7% and of the control group was 68.3% (P<0.05). Conclusion   Traditional Chinese medicine in combination with western medicine has good curative effect on children with chronic sinusitis.

    Expression and significance of aquaporin-4 in nasal polyps
    XU Zhen1, YU Hai-ling1, LIU Bing2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  48-50.  doi:10.6040/j.issn.1673-3770.0.2013.236
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    Objective   To study the expression and distribution of aquaporin4 (AQP-4) in nasal polyps and to explore the AQP-4 on formation of nasal polyps mechanism and function. Methods   By an immunohistochemical method, the test was carried out to explore the expression and distribution of AQP-4 in 60 nasal polyps and 30 inferior turbinate mucous membranes (all samples were chosen from clinical operations and fresh issues). The statistical analysis was performed with a two independent sample t-test. Results   Whether in nasal polyps or in inferior turbinate mucous membranes, AQP-4 was distributed in the epithelial cells, lamina propria glands cell, vascular endothelial and blood sinus. Nasal polyps in the epithelial cells, vascular endothelial and blood sinus number of positive cells were higher than in inferior turbinate mucosa with statistically significant differences. Conclusion   The expression of AQP-4 is significantly higher in epithelial cell, vascular endothelial and blood sinus, which reveals that AQP-4 is associated with rhinal secretion increase and nasal mucosa edema.

    Intranasal endoscopic dacryocystorhinostomy for chronic dacryocystitis
    SHI Yu-yong, LIU Ding-rong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  51-53.  doi:10.6040/j.issn.1673-3770.0.2013.269
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    Objective   To investigate the surgical approach, techniques and clinical efficacy of dacryocystorhinostomy under nasal endoscope in treatment of chronic dacryocystitis. Methods   Twenty-eight cases(30 eyes) of chronic dacryocystitis had undergone endoscopic dacryocystorbinostomy and were rinsed the lacrimal passage and nasal cavity routinely under nasal endoscopy after operation. Results   All chronic dacryocystitis were followed up in 6 months. The curative rate was 93.33% and the efficiency rate was 100%. Conclusion   Dacryocystorbinostomy is effect for chronic dacryocystitis with less injury.

    Retrograding silicon tube implantation into nasolacrimal canal in the process of dacryocystography for chronic dacryocystitis in 74 patients
    CHU Cui-ying, JIANG Guang-wei, QU Ming-xuan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  54-55.  doi:10.6040/j.issn.1673-3770.0.2013.202
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    Objective   To evaluate the clinical effect of retrograding implantation of silicon tube into nasolacrimal canal in combination with dacryocystography in treating chronic dacryocystitis.  Methods   Seventy-four patients with chronic dacryocystitis were performed retrograding implantation of silicon tube into nasolacrimal canal. All of the cases were given eyedrops, and the lacrimal passages were regularly irrigated after the surgery. Results   Followed up for a period of 6 months to 2 years, 68 (91.90%) eyes recovered, 4 (5.40%) had improvement, and 2 showed no change. The treatment was effective in 97.30 % of the patients. Conclusion   This method can be used in a wide range of indications, and it has advantages of convenient manipulation, saving time, and resulting in little pain, good effect, rapid recovery.

    Comparison of endoscopic resection  and a  conventional method for  submandibular gland
    TANG Su-cheng, CHEN Wei-xiong, WANG Yue-jian, ZHU Zhao-feng, HE Fa-yao, ZHANG Jian-li
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  56-58.  doi:10.6040/j.issn.1673-3770.0.2013.228
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    Objective   To investigate the feasibility and advantage of endoscopic resection of submandibular gland through a minimal incision. Methods   Twenty-six  patients, diagnosed as benign diseases of submandibular gland from 2006 to 2012, were treated with endoscopic resection of submandibular gland through a 2.0-2.5cm skin incision. The incision length, intraoperative bleeding, operation duration drainage of the wound and complication were reviewed and compared with the control group in which 65 patients received conventional surgical resection. Results   Surgery in all the 91 patients were successfully performed without relapse during the follow-up (1 to 5 years). Of the endoscopic group,the incision length, total intraoperative bleeding ,operation duration and drainage of the wound were 2.3±0.2cm, 9.4±2.2mL, 74±10min and 17.2±5.7mL, respectively. One case suffered from tongue numbness which disappeared in 2 weeks. No facial and hypoglossal nerve paralysis occurred  postoperatively. Compared with the control group, the incision length and bleeding dramatically decreased,  while the difference of operational duration was not significant. Conclusion   Endoscopeic resection of submandibular gland through a minimal incision could obtain better cosmetic results, which is a feasible way to treat benign submandibular gland disease.

    Cranio-maxillofacial trauma (500 cases report)
    ZHENG Li-you1, LI Xue-jun2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  59-61.  doi:10.6040/j.issn.1673-3770.0.2013.195
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    Objective   To investigate the demographic, causes and clinical characteristics of cranio-maxillofacial trauma (CMT) to determine the appropriate treatment. Methods   Among 1265 cases of ENT and/or maxillofacial injury, clinical data of 500 patients accompanied with brain injury were reviewed. Results   In 1256 cases, injuries located at or above the nasal-acoustic line in 388 cases(30.67%) but under the plane in 112 (8.85%). The incidence of brain injury was significantly associated with this plane(P<0.01). In 500 CMT cases, the male to female ratio was 4.1  to 1, with the common ages ranging from 20 to 49. The leading cause of trauma was traffic accident(47.80%). As for brain injury, there were 59.40% concussion, 11.80% brain contusion, and 6.20% intracranial hematoma. According to GCS scoring system, 88.40% belonged to mild injuries and according to GOS prognostic score, and 95.4% recovered well. Conclusion   Male is prone to CMT than females, esp. for young adults. The main reason is traffic accident. The nasal-acoustic line is helpful for the diagnosis. With correct and effective treatment, the death toll will be minimal.

    Applicaiton of near hairline coronal incision in otolaryngology and head and neck surgery
    GOU Dong-ming1, WANG Hai1, CHEN Jian-chao2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  62-64.  doi:10.6040/j.issn.1673-3770.0.2013.224
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    Objective   To explore the application of near hairline coronal incision in otolaryngology and head and neck surgery.  Methods   Totally, 28 patients were operated with near hairline coronal incision, including 20 internal fixation of zygomatic complex fracture, 4 frontal sinus cyst excision, 2 frontal sinus osteoma excision and 2 frontal benign tumor excision.  Results   All the 28 cases achieved satisfying curative results with primary wound healing. No facial scar, facial nerve paralysis or cerebrospinal fluid leakage occured after the operations.  Conclusion   The near hairline coronal incision is frequently applied in craniocerebral and maxillofacial surgery. The operative view is also sufficient for otolaryngology head and neck surgery. Compared with traditional approaches, it is more convenient for some upper or middle facial operations and can improve the quality of operation. Moreover, direct vision can avoid the complications, such as facial nerve injury and cerebrospinal fluid rhinorrhea. Meanwhile, it can effectively avoid the incision-related scar in conventional facial operations. In conclusion, this approach warrants the wide application in otolaryngology head and neck surgery.

    Analysis of foreign body induced retropharyngeal abscess
    SHANGGUAN Han-jing, GAO Xing-qiang, CHEN Wu-na, LUO Xian-yang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  65-66.  doi:10.6040/j.issn.1673-3770.0.2013.156
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    Objective   To investigate  the clinical characteristics of  foreign body induced retropharyngeal  abscess. Methods   Fourteen cases  of  foreign body induced  retropharyngeal  abscess  were  analyzed  retrospectively.  The  clinical  features were compared and summarized.  Results   ① The oneset age was  mostly  middle-aged; ② The sites and  ranges of  the   lesions  could be clearly  displayed  by  CT. ③ The key of treatment was  to  remove the  foreign  body  and  drain the abscess. Conclusion   The  Middle-aged  is  a  high incidence  group  for  foreign body induced retropharyngeal abscess. CT should  be  regarded  as the first choice to evaluate the lesion. The  approach  of  lateral neck incision  is the  main method to treat foreign body induced retropharyngeal abscess.

    Uvula-preserving uvulopalatopharyngoplasty  with two incisions under local anesthesia to treat moderate OSAHS caused by large tonsils
    LI Yong-qiang, ZHANG Wen-shan
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  67-69.  doi:10.6040/j.issn.1673-3770.0.2013.241
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    Objective   To discuss the method and effects of uvula-preserving uvulopalatopharyngoplasty  with two incisions under local anesthesia in the treatment of moderate OSAHS caused by large tonsils. Methods   Thirty-nine patients were treated by uvula-preserving uvulopalatopharyngoplasty with two incisions under local anesthesia. Two incisions meant that there was one incision at each side  and the incisions of tonsillectomy would unite with the reversed “U” incision on the soft palate . So the time could be saved and the difficulties of the operation could be reduced. During the postoperative follow-up, the patients’ symptoms, pharyngeal cavity and PSG were monitered. Results   The symptoms of all the patients in the group were improved  obviously. Compared with those before the treatment, AHI and the lowest SaO2 showed significant difference in 6 months and 12 months. Later.  33 cases were cured,including 4 excellence, 1 valid, and 1 invalid case 6 months later. Twelve months later, there were 32  cured cases, including 4 excellence, 2 valid, and 1 invalid cases. The total efficiency was 97.4%. No complications occurred. Conclusion   For the patients who suffer from moderate OSAHS caused by large tonsils, this method demonstrates lots of advantages such as safe procedure, fast recovery, good curative effect, and lowered medical cost.

    Clinical study of vitreous surgery for rhegmatogenous retinal detachment associated with choroidal detachment
    ZHANG Jing-jing1, HAN Fang-ju2
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  70-72.  doi:10.6040/j.issn.1673-3770.0.2013.207
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    Objective   To evaluate the efficacy of vitreous surgery combined with silicon oil tamponade for patients with rhegmatogenous retinal detachment associated with choroidal detachment. Methods   A total of 21 patients with rhegmatogenous retinal detachment associated with choroidal detachment were enrolled in this study.All the patients received vitrectomy and silicone oil tamponade with using non-contact wide-angle lens and some patients received combined lens surgery. The pre- and post-operative visual acuity, intraocular pressure(IOP) and retinal reattachment rate were analyzed. Results   The rate of retinal reattachment after single-surgery was 71.5%(15/21) and final reattachment rate was 90.5%(19/21). The best corrected visual acuity (BCVA) was >0.1 in 7 eyes (33.3%) after surgery, and visual acuity increased in 17 eyes (80.9%).  Average intraocular pressure(IOP) was 6.1mmHg before surgery and 14.8mmHg after surgery, with a significant difference between them (P<0.05).Conclusion   Vitreous surgery combined with silicon oil tamponade for patients with rhegmatogenous retinal detachment associated with choroidal detachment is efficient and safe.

    Clinical study of composite prism in treatment of juvenile myopia
    DAI Li-hua, ZHANG Xiu-guo, ZHANG Jing-jing, GUO Xia
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  73-75.  doi:10.6040/j.issn.1673-3770.0.2013.178
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    Objective   To investigate and evaluate the effects of composite prism on myopia progression in teenagers. Methods   One hundred and tuenty-six patients with myopia were randomly divided into two groups: treatment group (126 eyes) and control group(126 eyes). The treatment group weared composite prism and control group weared ordinary resin lenses. The two groups had no significant differences in age and refraction. They were followed up for 3 years, and refractive status, AC/A ratio,corneal curvature, and axial growth were evaluated and statistically analyzed.  Results   The myopic diopter deepened by (-0.43±0.24)DS in treatment group and (-0.91±0.56)DS in control group every year, and the difference was significant (P<0.01); the changes of the treatment group in axial length and corneal curvature had no statistical significance; more than 90% of the teenagers in treatment group felt very comfortable and no overt strabismus appeared. Conclusion   Composite prism can be used to control or slow the development of myopia effectively, and it is safe, comfortable, and acceptable for teenagers.

    Development of evaluation on voice
    KANG Sha-sha, LEI Da-peng
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  76-78.  doi:10.6040/j.issn.1673-3770.0.2013.231
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    With the development of life, patients who were attacked by voice disorders paid more attention to the recovery of voice, and more and more methods was used to evaluate the voice by computer technologies. At the same time, otolaryngologists paid more attentions on how to accurate assess voice and to guide treatment. This article is to synthesize a variety of different methods on evaluation of voice.

    Progress of candidate metastasis-suppressor gene and tumor
    LUO Xiao-zou, HONG Yu-ming
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  79-83.  doi:10.6040/j.issn.1673-3770.0.2013.205
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    Expression product of tumor metastasis suppressor gene(MTSS1) is an actin-binding protein which is widely expressed in many tissues but not metastatic tumors. MTSS1 plays important roles in the process of cell growth, tumor invasion and metastasis,. This article focuses on the structure, biological function and relationship of tumor metastasis suppressor gene with tumor metastasis.

    A review of tissue remodeling in chronic rhino-sinusitis
    LI Xue-sheng, QIAN Jin, LI Hou-en, LI Jin-rang
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  84-86.  doi:10.6040/j.issn.1673-3770.0.2013.143
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    Chronic rhino-sinusitis is characterized by persistent inflammation of the nasal and paranasal mucosa and is currently classified into two major subgroups on the basis of the absence or presence of nasal polyps. Current studies show that tissue remodeling existed in the chronic rhino-sinusitis developing. Transforming growth factor-beta and matrix metalloproteinases are critical factors involved in the remodeling process. To understand which kind of cytokine is involved and how it works will contribute to choose the best therapeutic target. Further study will be focused on the complicated pathway of tissue remodeling in chronic rhino-sinusitis.

    Serious nasal bleeding during pregnancy treated under endoscopy
    ZHANG Min, YIN Zhao-fu, BAI Yong
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  87-88.  doi:10.6040/j.issn.1673-3770.0.2013.208
    Abstract ( 1113 )   PDF (893KB) ( 464 )   Save
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    Cervical necrotizing fasciitis: case report and literature review
    WU Xi-fu, HUANG Jian-cong, ZHUANG Shi-min, HUANG Zi-zhen, YE Jin, ZHANG Ge-hua
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  89-90.  doi:10.6040/j.issn.1673-3770.0.2013.263
    Abstract ( 1250 )   PDF (1405KB) ( 733 )   Save
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    One case of titled disc syndrome misdiagnosed as optic atrophy
    LIU Zhe, HOU Yan-li, WANG Yan-ling
    JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY). 2014, 28(1):  91-92.  doi:10.6040/j.issn.1673-3770.0.2013.281
    Abstract ( 1714 )   PDF (1176KB) ( 1025 )   Save
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