JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Modification of endostatin with low molecular weight heparin and its angiogenesis effects on rabbit corneas

ZHU Wei1，TAO Xiang-chen2，LI Xin2，YUAN Zhong-fang2，MU Guo-ying2   

  1. 1. School of Medicine, Shandong University, Jinan 250012， Shandong;2. Department of Ophthalmology, Jinan Central Hospital, School of Clinical Medicine, Shandong University,  Jinan 250013
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-10-24 Published:2007-10-24
  • Contact: ZHU Wei

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Abstract: Objective To investigate the modification of endostatin (ES) with low molecular weight heparin (LMEH) and its inhibitory effects on corneal neovascularization（CNV）. Methods ES was modified with LMWH by a chemical method. The rabbit CNV model was made with alkali burning. LMWHES(group 1)， ES (group 2) and normal saline(control group) were subconjunctivally injected. Results The blood vessel was shorter and smaller in group 1 than in the other two groups(P<0.05) and the expression of VEGF in group 1 was also significantly lower than that of the other two groups(P<0.05). Conclusions LMWHES can effectively inhibit the growth of CNV and is superior to ES.

Key words: Low molecular weight heparin, Endostatin, Modification, Cornea, Neovascularization, Rabbit

CLC Number: 

  • R778.1
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