Abstract:

Objective    To investigate the impact of aspirin intolerance triad on pulmonary function and asthma clinical control. Methods    106 patients with asthma alone or with asthma in combination with allergic rhinitis or patients with aspirin intolerance triad were divided into the asthma group(n=35), the asthma combined with allergic rhinitis(AR) group(n=35) and the aspirin intolerance triad(AIT) group(n=36) at Shanghai Shuguang Hospital. Forced vital capacity(FVC), forced expiratory volume in one second(FEV1), forced expiratory volume in one second/ forced vital capacity(FEV1% FVC),peak expiratory flow(PEF), the Asthma Control Test(ACT) score and the Asthma Control Questionnaire(ACQ)score were evaluated respectively among the asthma alone group ,the asthma combined with AR group and the AIT group. Results    Patients in the AIT group had significantly(P<0.05) lower FVC, FEV1, FEV1% FVC and PEF than the asthma alone group. However patients in the AIT group had the same FVC, FEV1 and PEF as those in the asthma combined with AR group except for FEV1% FVC. The ACT score(14.2±4.5) and the ACQ score(2.7±1.5) in patients with AIT were significantly different with the asthma alone group, but were not significantly different with the asthma combined with AR group. Conclusion    AIT patients have serious airway inflammation and high airway resistance, and their lung functions and level of asthma control are bad. FEV1% FVC may be an effective and sensitive index to diagnose or evaluate AIT.

Key words: Aspirin intolerance triad, Allergic rhinitis, Pulmonary function, Asthma control questionnaire, Asthma, Asthma control test