ISSN 1673-3770 CN 37-1437/R
JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (3): 24-28.doi: 10.6040/j.issn.1673-3770.0.2015.340
Previous Articles Next Articles
HU Wenliang, ZHENG Yanqiu, CUI Xiaobo, CUI Yanru, SUN Yuanhao
CLC Number:
| [1] Gourin C G, Terris D J. Carcinoma of the hypopharynx[J]. Surg Oncol Clin N Am, 2004, 13(1):81-98. [2] Buckley J G, MacLennan K. Cervical node metastases in laryngeal and hypopharyngeal cancer: a prospective analysis of prevalence and distribution[J]. Head Neck, 2000, 22(4):380-385. [3] American Society of Clinical Oncology, Pfister D G, Laurie S A, et al. American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer[J]. J Clin Oncol, 2006, 24(22):3693-3704. [4] Piirsoo A, Kasak L, Kauts M L, et al. Protein kinase inhibitorSU6668 attenuates positive regulation of Gli proteins in cancer[J]. Biochim Biophys Acta, 2014, 1843(4):703-714. [5] Manning G, Whyte D B, Martine R, et al. The protein kinase complement of the human genome[J]. Science, 2002, 298(5600):1912-1934. [6] Okkenhaug K. Signaling by the phosphoinositide 3-kinase family inimmune[J]. Annu Rev Immunol, 2013, 31:675-704. [7] Kizub I V, Klymenko K I, Soloviev A I. Protein kinase C in enhanced vascular tone in diabetes mellitus[J]. Int J Cardiol, 2014, 174(2):230-242. [8] Barrett T, Suzek T O, Troup D B, et al. NCBI GEO: mining millions of expression profiles-database and tools[J]. Nucleic Acids Res, 2005, 33(Database issue):D562-566. [9] Joost S, Kalbermatten M, Bonin A. Spatial analysis method(sam): a software tool combining molecular and environmental data to identify candidate loci for selection[J]. Mol Ecol Resour, 2008, 8(5):957-960. [10] Basson M D, Zeng B, Downey C, et al. Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-β[J]. MolOncol, 2015, 9(2):513-526. [11] He L F, Wang T T, Gao Q Y, et al. Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells[J]. J Biomed Sci, 2011, 18(1):39-48. [12] Fridberg M, Kjellström S, Anagnostaki L, et al. Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls[J]. Pediatr Hematol Oncol, 2008, 25(6):528-540. [13] Xiao F, Zhang W, Zhou L, et al. microRNA-200a is an independent prognostic factor of hepatocellular carcinoma and induces cell cycle arrest by targeting CDK6[J]. Oncol Rep, 2013, 30(5):2203-2210. [14] Xia B, Yang S, Liu T, et al. miR-211 suppresses epithelial ovarian cancer proliferation and cell-cycle progression by targeting Cyclin D1 and CDK6[J]. Mol Cancer, 2015, 14(1):57-70. [15] Comstock C E, Augello M A, Goodwin J F, et al. Targeting cell cycle and hormone receptor pathways in cancer[J]. Oncogene, 2013, 32(48):5481-5491. [16] Zen Y, Harada K, Sasaki M, et al. Intrahepatic cholangio carcinoma escapes from growth inhibitory effect of transforming growth factor-beta1 by overexpression of cyclin D1[J]. Lab Invest, 2005, 85(4):572-581. [17] Wang J, Li X, Lu X, et al. The regulation of stat3 signal transduction pathway to G1 to S phase of laryngo carcinoma cell[J]. Clin J Otorhinolarynol Head Neck Surg, 2008, 22(15):699-703. [18] Kwon D Y, Lee H E, Weitzel D H, et al. Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition[J]. J Med Chem, 2015, 58(19):7659-7671. [19] Zupa A, Improta G, Silvestri A, et al. A pilot characterization of human lung NSCLC by protein pathway activation mapping[J]. J Thorac Oncol, 2012, 7(12):1755-1766. [20] Razidlo G L, Magnine C, Sletten A C, et al. Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion[J]. Cancer Res, 2015, 75(14):2907-2915. [21] Cheung C H, Coumar M S, Chang J Y, et al. Aurora kinase inhibitor patents and agents in clinical testing: an update(2011-13)[J]. Expert Opin Ther Pat, 2014, 24(9):1021-1038. [22] Murphy C G, Dickler M N. The Role of CDK4/6 Inhibition in Breast Cancer[J]. Oncologist, 2015, 20(5):483-490. [23] Chen C, Song X, Ma S, et al. Cdc42 inhibitor ML141 enhances G-CSF-induced hematopoietic stem and progenitor cell mobilization[J]. Int J Hematol, 2015, 101(1):5-12. [24] Gray J E, Altiok S, Alexandrow M G, et al. Phase 2 randomized study of enzastaurin(LY317615)for lung cancer prevention in former smokers[J]. Cancer, 2013, 119(5):1023-1032. [25] Rampling R, Sanson M, Gorlia T, et al. A phase I study of LY317615(enzastaurin)and temozolomide in patients with gliomas(EORTC trial 26054)[J]. Neuro Oncol, 2012, 14(3):344-350. [26] Blevins D P, Dadu R, Hu M, et al. Aerodigestive fistula formation as a rare side effect of antiangiogenic tyrosine kinase inhibitortherapy for thyroid cancer[J]. Thyroid, 2014, 24(5):918-922. [27] 潘新良, 雷大鹏, 许风雷, 等. 下咽癌的外科治疗[J]. 山东大学耳鼻喉眼学报, 2007, 21(1):1-6. PAN Xinliang, LEI Dapeng, XU Fenglei, et al. Surgical treatment of lower pharyngeal carcinoma[J]. J Otolaryngol Ophthalmol Shandong Univ, 2007, 21(1):1-6. |
| [1] | SUN Fanmin, ZHANG Juanmei, GAO Jie, ZHAO Jun. Advances in Shh, PI3K/AKT, and MMP-2 pathways and correlations in myopia [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 142-148. |
| [2] | PAN Linlin, WAN Jiaming, LI Yue, HE Long. Autophagy-related long noncoding RNA is a prognostic indicator for head and neck squamous cell carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 97-107. |
| [3] | KE Bingbing, CHEN Ming, WANG Hongyang, LI Chunyan, YIN Shankai. CAMK4-mediated oxidative stress injury in auditory central neurons induced by bilirubin [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 1-10. |
| [4] | YANG Ming, LIU Xuexia, ZHANG Hua. Progress of m6A recognition protein IGF2BPs in head and neck cancer [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 153-161. |
| [5] | WANG Mingming, LUO Yang, HE Shaojuan, ZHANG Xianxing, LI Xuezhong. Bioinformatic analysis of the transcriptome of basal stem cells of individuals with chronic rhinosinusitis with nasal polyps [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 6-15. |
| [6] | ZHANG Yonghong, ZHANG Hui, WANG Caihua, YANG Xinxin, WU Yungang, ZHAO Yufeng, PANG Taizhong, LI Xiaoyu. Construction of an immune-associated gene prognostic model and screening of targeted molecular drugs for laryngeal squamous cell carcinoma based on the TCGA database [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 54-62. |
| [7] | HAO Hong, CHEN Gang, WANG Lin’e. Key candidate genes associated with the molecular mechanisms of adenoid cystic carcinoma identified by bioinformatics [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(5): 99-106. |
| [8] | HOU Lingxiao, ZHANG Changcui, XU Anting, FAN Xintai, WANG Na. Role of CD4+ T cells from nasal mucosa in the pathogenesis of patients with seasonal allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(4): 96-104. |
| [9] | WANG Lingwa, WANG Ru, FANG Jugao. Bioinformatics analysis of key molecular markers for malignant transformation of laryngeal papilloma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2023, 37(1): 47-55. |
| [10] | CHENG Yao, ZHANG Zhen, YANG Ji, FENG Chengmin, DENG Qicheng, ZHANG Xi, ZHAO Rui, ZHU Xin, WU Junzhi, LIU Hai, DENG Shishan. Expression and clinical significance of CIP2A in hypopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2022, 36(2): 40-44. |
| [11] | QI Wenwen, CHEN Luqiu, JIA Tao, CHEN Xuemei, ZHANG Jie, ZHANG Hao, JIN Peng, ZHANG Hu. Potential biomarkers and bioinformatics analysis of differentially expressed genes in recurrent laryngeal papilloma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(5): 75-84. |
| [12] | WANG Yayue,SUN Juan. Research progress on differentially-expressed protein kinases and inhibitors in hypopharyngeal carcinoma [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2021, 35(1): 119-124. |
| [13] | ObjectiveThe aim of this study was to provide new perspectives and targets for the treatment of HNSCC by screening differentially expressed genes during cetuximab treatment of head and neck squamous cell carcinoma(HNSCC)using bioinformatics. MethodsThe chip dataset, GSE109756, was downloaded from the GEO database, and the online analysis tool, GEO2R, was used to screen differentially expressed genes in head and neck squamous cell carcinoma tissues treated with and without cetuximab. The DAVID 6.8 and STRING online software were used to analyze the function of the differentially expressed genes, their pathway enrichment, and their protein interactions. Cytoscape was used to visualize and analyze the protein interactions. The online analysis tool, X2K, was used to find the transcription factors, the kinases of differentially expressed genes, and their mutual regulatory relationship with the targeted genes. ResultsNinety-one differentially expressed genes, including 50 up-regulated and 41 down-regulated genes(P<0.05; | logFC | > 1), were found in head and neck squamous cell carcinoma tissues treated with and without cetuximab. The GO and KEGG pathway analyses suggested that these differentially expressed genes were mainly enriched with immunomodulation, extracellular matrix, and other processes. Through the construction of a protein-protein interaction network, we screened CD163, VSIG4, and 3 other core differentially expressed genes(P<0.05), which were up-regulated after cetuximab treatment. In addition, our analysis shows that transcription factors, including SUZ12, TP63, and ESR1, played a key role in cetuximab treatment(P<0.05)and MAPK14, CDK1, and MAPK1 were the most important kinases during the process(P<0.05). ConclusionCD163, VSIG4, and the aforementioned transcription factors and protein kinases may be involved in the biological processes that underlie cetuximab treatment of HNSCC. This study provides new perspectives to facilitate further understanding of the biological mechanism that underlies cetuximab treatment of HNSCC and the exploration of the effectiveness of HNSCC treatment.. Analysis of differentially expressed genes during cetuximab treatment of head and neck squamous cell carcinoma using bioinformaticsYU Kena1, SUN Kaiyue2, ZHANG Jie1, JIN Peng1 1. Department of Otorhinolaryngology & Head and Neck Surgery, The Second Hospital of Shandong University, Jinan 250033, Shandong, China; 2. Shandong Provincial Otorhinolaryngology Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250022, Shandong, ChinaAbstract: [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2020, 34(4): 117-124. |
| [14] | LI Xiaoming, SONG Qi, LI Hongxia, TAO Zhenfeng, SHEN Yupeng, XIAO Shufen. Reconstruction of hypopharyngeal defects after ablation of advanced head and neck squamous carcinoma involving hypophaynx with pectoralis major myocutaneous flap. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(3): 4-9. |
| [15] | DONG Pin, YING Xinjiang, CHEN Xinwei, DENG Zhihong, ZHANG Shaoqiang, YU Ziwei, JIN Bin, SUN Zhenfeng, XIE Jin, ZHU Jiangcai. Preliminary clinical analysis of neo-adjuvant chemotherapy with nimotuzumab plus nedaplatin and fluorouracil in hypopharyngeal squamous cell carcinoma. [J]. JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY), 2016, 30(3): 10-14. |
|
||