JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2016, Vol. 30 ›› Issue (4): 26-29.doi: 10.6040/j.issn.1673-3770.0.2016.032

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Study on single nucleotide polymorphisms of partial allergic rhinitis-associated haplotype module genes.

TENG Weiqiang1, CHEN Xiaoping2, ZHANG Yan2, ZHOU Enhui3, YAO Wenhao3, LI Li   

  1. 1. Department of Otolaryngology &Head and Neck Surgery, Shanghai Changzheng Hospital, Shanghai 200003, China;2. Department of Otolaryngology &Head and Neck Surgery, Gongli Hospital of Pudong Area, Shanghai 200135, China;3. Ningxia Medical University, Yinchuan 750004, Ningxia, China
  • Received:2016-01-24 Online:2016-08-16 Published:2016-08-16

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Abstract: Objective To detect whether there exist allergic rhinitis-associated hapoltype module genes(SDAD1, CXCL10, CXCL11 and EoBL)and single nucleotide polymorphisms(SNP)on chromosome as well as whether these genes affect on SNP. Methods The blood sample DNA of patients with allergic rhinitis in hereditary background group and distribution group was extracted, and gene sequencing was conducted following polymerase chain reaction(PCR)primer design, synthesis and amplification. Results A total of 46 sites were detected in both groups, of which 34 had mutations, with total mutation rate being 78.3%. And there was significant difference in the gene mutation of allergic rhinitis between hereditary background group(66.67%)and distribution group(78.57%)(P=0.58). Conclusion SDAD1, CXCL9, CSCL10 and CXCL11 genes are expressed successively on chromosome haplotype modules in patients with allergic rhinitis, and SNP is extensively distributed on allergic rhinitis-associated genes, including SDAD1, CXCL10, CXCL11 and EoBL, but hereditary factors have insignificant influence on these mutations.

Key words: Haplotype module genes, Single nucleotide polymorphisms, Allergic rhinitis

CLC Number: 

  • R765.21
[1] Bachert C, Jorissen M, Bertrand B, et al. Allergic Rhinitis and its impact on asthma update(ARIA 2008). The Belgian perspective[J]. B-ENT, 2008, 4(4):253-257.
[2] Settipane R A, Charnock D R. Epidemiology of rhinitis:allergic and nonallergic[J]. Clin Allergy Immunol, 2007, 19:23-34.
[3] 胡頔, 胡国华, 魏萍, 等. IL-23R基因多态性与变应性鼻炎遗传易感性研究[J]. 临床耳鼻咽喉头颈外科杂志, 2014(2):85-89. HU Di, HU Guohua, WEI Ping, et al. Association between IL-23R gene polymorphism and genetic susceptibility of allergic rhinitis[J]. J Clin Otorhinolaryngol Head Neck Surgery, 2014(2):85-89.
[4] 王长青, 彭诗东. TIM-3基因的多态性与变应性鼻炎的相关性[J]. 山西医药杂志, 2008, 37(15):688-690. WANG Changqing, PENG Shidong. Study on relationship between polymorphism sites of tim-3 and allergic rhinitis in a population of adult hans from shanxi province of china[J]. Shanxi Med J, 2008, 37(15):688-690.
[5] Zhang J, Noguchi E, Migita O, et al. Association of a haplotype block spanning SDAD1 gene and CXC chemokine genes with allergic rhinitis[J]. J Allergy Clin Immunol, 2005, 115(3):548-554.
[6] Kim J J, Lee J H, Jang C H, et al. Chemokine RANTES promoter polymorphisms in allergic rhinitis[J]. Laryngoscope, 2004, 114(4):666-669.
[7] Chae S C, Park Y R, Oh G J, et al. The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis[J]. Immunogenetics, 2005, 56(10):760-764.
[8] 马莉, 陈大灵, 章如新, 等. 江苏南通地区变应性鼻炎遗传流行病学研究[J]. 中华耳鼻咽喉头颈外科杂志, 2007, 42(9):643-646. MA Li, CHEN Daling, ZHANG Ruxin, et al. Genetic epidemiological study on allergic rhinitis in nantong region of jiangsu province[J]. Chin J Otorhinolaryngol Head Neck Surgery, 2007, 42(9):643-646.
[9] 熊伯华, 何哲玲, 覃平, 等. 一个变应性鼻炎家系的遗传特征及调查分析[J]. 实用预防医学, 2006, 13(1):120-121. XIONG Bohua, HE Zheling, QIN Ping, et al. An investigation and analysis of the genetic characteristics of allergic rhinitis genealogy[J]. Pract Preven Med, 2006, 13(1):120-121.
[10] 王辉, 程志英, 任润兰. 174例变应性鼻炎与遗传和环境因素的关系[J]. 中国自然医学杂志, 2007, 9(2):112-114. WANG Hui, CHENG Zhiying, REN Runlan. A case-control study of the genetic and environmental factors of allergic rhinitis[J]. Chin J Natural Med, 2007, 9(2):112-114.
[11] Dávila I, Mullol J, Ferrer M, et al. Genetic aspects of allergic rhinitis[J]. J Investig Allergol Clin Immunol, 2009, 19(Suppl 1):25-31.
[12] 许昱. 基因和环境的相互作用与变应性鼻炎[J]. 中国医学文摘(耳鼻咽喉科学), 2011,26(6):328-331. XU Yu. Genes interaction with the environment and allergic rhinitis[J]. Chin ENT News Reviews, 2011,26(6):328-331.
[13] 崔忠涛, 张华, 刘云连, 等. 新疆部分地区维、汉族变应性鼻炎患者HLA-DQB1基因多态性分析[J]. 临床耳鼻咽喉头颈外科杂志, 2011, 25(14):645-648. CUI Zhongtao, ZHANG Hua, LIU Yunlian, et al. Analysis of hla-dqb1 polymorphism for patienets with allergic rhinitis of uygur and han people in xinjiang[J]. J Clin Otorhinolaryngol Head Neck Surg, 2011, 25(14):645-648.
[14] 崔忠涛, 张华. 新疆部分地区汉族变应性鼻炎患者HLA-DRB1基因多态性分析[J]. 新疆医科大学学报, 2010, 33(3):253-254,257. CUI Zhongtao, ZHANG Hua. Analysis of hla-drb1 polymorphism for patienets with allergic rhinitis of han people in xinjiang[J]. J Xinjiang Med Univ, 2010, 33(3):253-254,257.
[15] 张媛, 张罗, 韩德民. 变应性鼻炎的遗传学基础[J]. 临床耳鼻咽喉头颈外科杂志, 2007, 21(23):1101-1104. ZHANG Yuan, ZHANG Luo, HAN Demin. The genetic basis of allergic rhinitis[J]. J Clin Otorhinolaryngol Head Neck Surg, 2007, 21(23):1101-1104.
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