Abstract: Objective To explore the relevant prognostic factors of sudden deafness and selection of course of treatment. Methods Theclinical data of 185 patients with sudden deafness(228 ears)treated in the Affiliated Hospital of Qingdao University were retrospectively analyzed. The influence of gender, age, lesion sides, concurrent symptoms, audiogram types, duration between onset and treatment, pure tone average of injury frequency and course of treatment on overall response rate(ORR)was analyzed. After screening the relevant factors, multi-factor binary Logistic regression analysis was applied. Results Among 228 ears, 144 ears were non-effective, 31 ears were effective, 23 ears were markedly effective, and 30 ears were healed. ORR was 36.8%. Single factor analysis showed that gender, age, audiogram types, duration between onset and treatment, pure tone average of injury frequency and course of treatment were closely related to ORR(P<0.05), but not to lesion sides and concurrent symptoms, such as vertigo, tinnitus and ear fullness(P>0.05). Multi-factor regression analysis displayed that gender, age,audiogram types, duration between onset and treatmentand course of treatment all had a certain correlation with ORR(P<0.05), but the pure tone average of injury frequency was not correlated with ORR(P>0.05). Conclusion The prognosis of female patients is better than male patients. With age growing and duration between onset and treatment prolonging, the ORR has the decreased tendency. The prognosis oflow-frequencydescending type isthe best,followed by the flat-type andcompletely deafness type, and the high-frequencydescending type is the worst. Early treatment can improve the clinical efficacy of sudden deafness, and the patients who failin the first course of treatment shouldcontinue to be treated for two courses of treatment.

Key words: Relevant factors, Sudden deafness, Prognosis, Course of treatment