JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY) ›› 2018, Vol. 32 ›› Issue (3): 68-72.doi: 10.6040/j.issn.1673-3770.0.2018.044

Previous Articles     Next Articles

Influence of patient management on the clinical effect of sublingual dermatophagoides farinae drops in patients

WU Xiangping   

  1. Department of Otorhinolaryngology, Dongguan Kanghua Hospital, Dongguan 523080, Guangdong, China
  • Received:2018-01-16 Online:2018-05-20 Published:2018-05-20

PDF (PC)

368

Abstract: Objective To analyze the influence of different patient management methods on the clinical effect and compliance to treatment with sublingual dermatophagoides farinae drops in patients with allergic rhinitis(AR). Methods One hundred and eighty patients with AR were randomly divided into a We-Media management Group(Group A, 90 patients)and a telephone management group(Group B, 90 patients). All patients were treated with sublingual immunotherapy(SLIT). In Group A, doctor-patient WeChat and/or QQ groups were formed. The doctor in charge acted as group leader, prepared monthly plans, sent to the patients SLIT-related information more than 3 times a week, and assessed patient reported outcome. In Group B, the patients were provided with on-the-spot demonstration and explanation and were followed up by telephone once every 3 month. We statistically analyzed dropout rates and the curative effect in the two groups at 1 year. Results The dropout rate in groups A and B was 13.3%(12/90)and 32.2%(29/90), respectively and the difference was statistically significant(χ2=9.128,P=0.003). The symptom scores before and after treatment were significantly different in both groups(P<0.05). There was no significant difference between Groups A and B before treatment(P>0.05), while the difference in the score of each symptom between the groups after treatment was significant(P<0.05). In Group A, the results were markedly effective in 15 patients(16.67%), effective in 49(54.44%), and ineffective in 26(28.89%), with a general effective rate of 71.11%(64/90). In Group B, the results were markedly effective in 13 patients(14.44%), effective in 26(28.89%), and ineffective in 51(56.67%), with a general effective rate of 43.33%(39/90). Conclusion The clinical effect and treatment compliance can be improved in patients with AR receiving SLIT by We-Media management.We-Media management is more advantageous especially in the long-term.

Key words: Allergic rhinitis, Sublingual immunotherapy, Patient management, We-Media, Clinical effect, Compliance

CLC Number: 

  • R765.4
[1] 中华医学会耳鼻咽喉头颈外科学分会鼻科学组, 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组. 变应性鼻炎诊断和治疗指南(2015 年,天津)[J]. 中华耳鼻咽喉头颈外科杂志, 2016, 51(1):6-24.
[2] 邱前辉. 变应性鼻炎免疫治疗的现状和未来[J]. 临床耳鼻咽喉头颈外科杂志, 2017, 31(1):9-12. QIU Qianhui. Current status and future of immunotherapy for allergic rhinitis[J]. J Clin Otorhinolaryngol Head Neck Surg, 2017, 31(1):9-12.
[3] Roxbury CR, Lin SY. Efficacy and safety of subcutaneous and sublingual immunotherapy for allergic rhinoconjunctivitis and asthma[J]. Otolaryngol Clin North Am, 2017, 50(6):1111-1119.
[4] 程雷. 特异性免疫治疗是变应性鼻炎的一线疗法[J]. 山东大学耳鼻喉眼学报, 2016, 30(4):1-2. CHENG Lei. Allergen-specific immunotherapy as the first-line treatment for allergic rhinitis[J]. J Otolaryngol Ophthalmol Shandong Univ, 2016, 30(4):1-2.
[5] Cox LS. Sublingual immunotherapy for allergic rhinitis: is 2-year treatment sufficient for long-term benefit?[J]. JAMA, 2017, 317(6):591-593.
[6] Schäfer U, Kienle-Gogolok A, Hadler M, et al. Treatment satisfaction during sublingual immunotherapy with a five-grass pollen tablet for allergic rhinoconjunctivitis: a prospective, non-interventional study[J]. Drugs Real World Outcomes, 2017, 4(2):109-117.
[7] Edwards TS, Wise SK. Clinical Applications of Sublingual Immunotherapy[J]. Otolaryngol Clin North Am, 2017, 50(6):1121-1134.
[8] 韩亮, 尤权杰, 李志, 等. 舌下免疫治疗变应性鼻炎满2年终止1年的疗效分析[J]. 中华耳鼻咽喉头颈外科杂志, 2017, 52(7):497-500. HAN Liang, YOU Quanjie, LI Zhi, et al. Evaluation of efficacy of 1 year after completing the 2-year specific sublingual immunotherapy treatment course in allergic rhinitis[J]. Chin J Otorhinolaryngol Head Neck Surg, 2017, 52(7):497-500.
[9] Egert-Schmidt A, Martin E, Mueller J, et al. Patients' compliance towards high -dose hypoallergenic and unmodified SCIT treatment schedules is superior to sublingual immunotherapy[J]. Allergy, 2011, 66(Suppl 94): 628-629.
[10] Wang T, Li Y, Wang F, et al. Nonadherence to sublingual immunotherapy in allergic rhinitis: a real-life analysis[J]. Int Forum Allergy Rhinol, 2017, 7(4):389-392.
[11] 崔珑, 王智楠, 徐忠强. 电话随访对粉尘螨滴剂舌下脱敏治疗变应性鼻炎依从性的评价[J]. 临床耳鼻咽喉头颈外科杂志, 2011, 25(8):364-366. CUI Long, WANG Zhinan, XU Zhiqiang. The analyse of telephone follow-up affecting the compliance of sublingual desensitization treatment to allergic rhinitis patients[J]. J Clin Otorhinolaryngol Head Neck Surg, 2011, 25(8):364-366.
[12] 张严文, 程雷. 舌下免疫治疗的临床现状及问题[J]. 中国中西医结合耳鼻咽喉科杂志, 2017, 25(3):161-163, 173.
[13] Marogna M, Spadolini I, Massolo A, et al. Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study [J]. J Allergy Clin Immunol, 2010, 126(5):969-975.
[1] LYU Qian, TANG Yuan, GU Zijun, SHI Sailei, LIU Ping, WAN Wenjin. Current status of benefit finding among patients with allergic rhinitis and its influence factors [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 21-28.
[2] GU Min, LU Meiping. Advances in the application of nanomedicine delivery systems in allergen immunotherapy for allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(1): 106-111.
[3] QIN Nana, LI Yufen, SUN Yuhao, WEI Jian, LI Qin. Effect of interleukin-13 receptor-α2 on nasal mucosal remodeling in rats with allergic rhinitis by TGF-β1/Smad signaling pathway [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 71-77.
[4] DU Kangli, ZHENG Zhenyu, XU Zhanjiang, ZHANG Yu, CHEN Lu, LU Mengyao. Construction and validation of risk prediction model for nasal septal deviation complicated with chronic sinusitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 78-86.
[5] XIONG Qin, ZHANG Yan, WU Rina, LI Feng, TANG Lixing. Application of intranasal corticosteroids in pediatrics [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(6): 160-167.
[6] XU Xuemeng, FAN Lei, YU Wangbo, JIANG Zhiyue, PAN Chen, HUANG Yongqin. Meta-analysis of the efficacy of omalizumab in combination with specific immunotherapy for allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 26-33.
[7] HUANG Huan, HUA Hongli, DENG Yuqin, JIANG Chengyang, WANG Yuwei, YANG Xinghai. Correlation of allergic rhinitis, tonsil adenoid hypertrophy, and sinusitis in children and analysis of its clinical guiding value [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 34-41.
[8] LIU Yijun, GU Yue, GUAN Dayu, YANG Yucheng, SHEN Yang. The long-term clinical efficacy and safety of vidian neurectomy in refractory allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 42-48.
[9] ZHANG Ting, WANG Meilan, GAO Yingqin. Research progress of IL-35 in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(5): 139-147.
[10] ZHANG Zhuping, PENG Zican, XIAO Zhenlong, LI Cheng, YU Di, WANG Xinglong, CHEN Wei, Guo Bei. The value of a novel nasal secretion eosinophil cationic protein-myeloperoxidase test paper assay in allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(3): 129-134.
[11] LIU Chang, YANG Jingpu, GAO Yu, WANG Wenjia. Analysis of allergen detection results in children with allergic rhinitis in the Changchun area [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 51-58.
[12] ZHOU Heqing, SHEN Qi. Research progress on biomarkers of traditional Chinese medicine in the treatment of allergic rhinitis [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(2): 168-176.
[13] GUO Zhenping, LI Xuebing. A survey of the psychological characteristics, sleep quality, and correlation with clinical outcomes in patients with chronic subjective tinnitus [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 1-7.
[14] WANG Manxian, ZHENG Quan, YANG Liang. Research progress in the treatment of allergic rhinitis with bacterial lysates [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2025, 39(1): 141-145.
[15] LIU Chang, FANG Hongyan, LIU Xiao, FU Dongna, WANG He, WANG Jing, YANG Jingpu. Analysis of sensitization characteristics of Artemisia pollen in autumn allergic rhinitis in the Changchun area of China [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2024, 38(5): 13-19.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Website Copyright: Editorial Office of Journal of Otolaryngology and Ophthalmology of Shandong University
Address: No.27 Shanda South Road, Jinan, Shandong, China. Post code: 250100 Tel: +86-0531-88366912 Email: ebhxb@sdu.edu.cn Supported by Beijing Magtech Co.Ltd