J Otolaryngol Ophthalmol Shandong Univ ›› 2018, Vol. 32 ›› Issue (4): 28-31.doi: 10.6040/j.issn.1673-3770.0.2017.170

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Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps

Effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with eosinophilic chronic sinusitis accompanied by nasal polyps   

  1. HUANG Kaifeng
  • Received:2017-04-19 Online:2018-07-20 Published:2018-07-20

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Abstract: Objective The aim of this study was to investigate the effect of short-term glucocorticoid inhalation on nasal symptoms and adrenocortical function in patients with both eosinophilic chronic sinusitis and nasal polyps. Methods A total of 40 patients with eosinophilic chronic sinusitis with nasal polyps were enrolled from June 2013 to June 2016 in the hospital, and they were randomly divided into two groups: one control group(20 patients)with glucocorticoid treatment by nasal spray and one observation group(20 patients)with glucocorticoid treatment by inhalation. The short-term clinical efficiency, visual analogue scale(VAS)scores of nasal symptoms, Lund-Kennedy endoscopic score, eosinophil(EOS)count, and serum cortisol concentration were compared between these two groups before and after treatment. The follow-up recurrence rate in both groups was also investigated. Results The clinical excellence and overall efficiency were significantly higher in the observation group than in the control group(P<0.05). The VAS scores of nasal symptoms and Lund-Kennedy endoscopic score were significantly lower in the observation group than in the control group after treatment, and the observation group also showed significantly decreased aforementioned scores after treatment compared with before treatment(P<0.05). The follow-up recurrence rates in 3 months and 6 months were significantly lower in the observation group than in the control group(P<0.05). EOS count was significantly lower in the observation group than in the control group after treatment, and the observation group also showed significantly reduced EOS count after treatment compared with before treatment(P<0.05). No significant differences in serum cortisol concentration were observed between these two groups both before and after treatment(P>0.05). Conclusion Compared with glucocorticoid treatment by nasal spray, glucocorticoid treatment by inhalation can significantly relieve nasal symptoms, inhibit the aggregation of eosinophils, and reduce the long-term recurrence risk, but the inhalation treatment has no significant effects on the adrenocortical function in patients with both eosinophilic chronic sinusitis and nasal polyps.

Key words: Glucocorticoid, Chronic sinusitis, Inhalation, Nasal polyps, Eosinophil

CLC Number: 

  • R765.4
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