Journal of Otolaryngology and Ophthalmology of Shandong University ›› 2019, Vol. 33 ›› Issue (1): 49-52.doi: 10.6040/j.issn.1673-3770.1.2018.033

• Research Progress • Previous Articles     Next Articles

Advances in interaction mechanisms and treatment strategy between chronic rhinosinusitis with nasal polyp and asthma

Yu ZHANG(),Xicheng SONG*()   

  1. Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong, China
  • Received:2018-11-06 Online:2019-01-20 Published:2019-01-28
  • Contact: Xicheng SONG E-mail:superzhang013@163.com;songxicheng@126.com

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Abstract:

Chronic rhinosinusitis with nasal polyp (CRSwNP) and asthma are representative chronic inflammatory diseases, which often coexist in the upper and lower airways. It is difficult to perform an effective therapy for patients with CRSwNP accompanied by asthma because interaction mechanisms and therapeutic effects after medical treatment and endoscopic sinus surgery remain unclear. The European position paper on rhinosinusitis and nasal polyps 2012 (EPOS 2012) presents detailed guidelines on the therapy of CRSwNP with or without asthma, including intranasal corticosteroids, nasal irrigation with saline, and so on. In addition, comprehensive follow-up treatments need to be performed according to the feature and severity of symptoms of CRSwNP. Research shows that it is beneficial for improving the prognosis of patients with CRSwNP accompanied by asthma by combining sinus surgery with medical treatment, but further randomized clinical trials are needed to better understand the management of asthma accompanied by CRSwNP.

Key words: Chronic rhinosinusitis with nasal polyp, Asthma, United airways, Pathogenesis, Therapy

CLC Number: 

  • R765.41
1 Gordon BR . Asthma: an important disease to otolaryngologists-Part Ⅰ: Suspecting and diagnosing asthma[J]. Ear Nose Throat J, 1996, 75 (2): 97- 101.
2 陈枫虹, 史剑波. 鼻科医生为什么要关注慢性鼻-鼻窦炎患者的下呼吸道[J]. 临床耳鼻咽喉头颈外科杂志, 2015, 29 (5): 478- 482.
doi: 10.13201/j.issn.1001-1781.2015.05.028
3 Ahmadiafshar A , Farjd HR , Moezzi F , et al. Nasal polyposis in patients with asthma and allergic rhinitis[J]. J Laryngol Otol, 2012, 126 (8): 780- 783.
doi: 10.1017/S0022215112000771
4 顾晓, 叶萍, 陈凤仪, 等. 慢性鼻-鼻窦炎伴鼻息肉患者肺功能检测分析及临床意义[J]. 中华耳鼻咽喉头颈外科杂志, 2013, 48 (3): 244- 247.
doi: 10.3760/cma.j.issn.1673-0860.2013.03.016
5 Kariya S , Okano M , Oto T , et al. Pulmonary function in patients with chronic rhinosinusitis and allergic rhinitis[J]. J Laryngol Otol, 2014, 128 (3): 255- 262.
doi: 10.1017/S0022215114000450
6 Kariya S , Okano M , Higaki T , et al. Pulmonary function in never-smoker patients with chronic rhinosinusitis[J]. Int Forum Allergy Rhinol, 2015, 5 (11): 990- 995.
doi: 10.1002/alr.21628
7 Zhang L , Zhang L , Zhang CH , et al. The lung function impairment in non-atopic patients with chronic rhinosinusitis and its correlation analysis[J]. Clin Exp Otorhinolaryngol, 2016, 9 (4): 339- 345.
doi: 10.21053/ceo.2015.01641
8 Uraguchi K , Kariya S , Makihara S , et al. Pulmonary function in patients with eosinophilic chronic rhinosinusitis[J]. Auris Nasus Larynx, 2018, 45 (3): 476- 481.
doi: 10.1016/j.anl.2017.07.020
9 Williamson PA , Vaidyanathan S , Clearie K , et al. Airway dysfunction in nasal polyposis: a spectrum of asthmatic disease[J]. Clin Exp Allergy, 2011, 41: 1379- 1385.
doi: 10.1111/j.1365-2222.2011.03793.x
10 Ragab A , Clement P , Vincken W . Correlation between the cytology of the nasal middle meatus and BAL in chronic rhinosinusitis[J]. Rhinology, 2005, 43 (1): 11- 17.
doi: 10.1097/00129492-200503000-00042
11 Ediger D , Sin BA , Heper A , et al. Airway inflammation in nasalpolyposis: immunopathological aspects of relation to asthma[J]. Clin Exp Allergy, 2005, 35 (3): 319- 326.
doi: 10.1111/j.1365-2222.2005.02194.x
12 Håkansson K , Bachert C , Konge L , et al. Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma: the united airways concept further supported[J]. PLoS One, 2015, 10 (7): e0127228.
doi: 10.1371/journal.pone.0127228
13 Rix I , Håkansson K , Larsen CG , et al. Management of chronic rhinosinusitis with nasal polyps and coexisting asthma: A systematic review[J]. Am J Rhinol Allergy, 2015, 29 (3): 193- 201.
doi: 10.2500/ajra.2015.29.4178
14 Chen FH , Zuo KJ , Guo YB , et al. Long-term results of endoscopic sinus surgery-oriented treatment for chronic rhinosinusitis with asthma[J]. Laryngoscope, 2014, 124 (1): 24- 28.
doi: 10.1002/lary.24196
15 Alobid I , Benítez P , Bernal-Sprekelsen M , et al. Nasal polyposis and its impact on quality of life: comparison between the effects of medical and surgical treatments[J]. Allergy, 2005, 60 (4): 452- 458.
doi: 10.1111/j.1398-9995.2005.00725.x
16 Schäper C , Noga O , Koch B , et al. Anti-inflammatory properties of montelukast, a leukotriene receptor antagonist in patients with asthma and nasal polyposis[J]. J Invest Allergy Clin Immunol, 2011, 21 (1): 51- 58.
doi: 10.1089/jir.2010.0112
17 Ragab S , Parikh A , Darby YC , et al. An open audit of montelukast, a leukotriene receptor antagonist, in nasal polyposis associated with asthma[J]. Clin Exp Allergy, 2001, 31 (9): 1385- 1391.
doi: 10.1046/j.1365-2222.2001.01160.x
18 Gevaert P , Calus L , Van Zele T , et al. Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma[J]. J Allergy Clin Immunol, 2013, 131 (1): 110- 116.
doi: 10.1016/j.jaci.2012.07.047
19 Weinstein SF, Katial RK, Bardin P, et al. Effects of reslizumab on asthma outcomes in a subgroup of eosinophilic asthma patients with self-reported chronic rhinosinusitis with nasal polyps[J]. J Allergy Clin Immunol Pract, 2018, pii: S2213-2198(18)30557-9. doi: 10.1016/j.jaip.2018.08.021.
20 Ragab SM , Lund VJ , Scadding G . Evaluation of the medical and surgical treatment of chronic rhinosinusitis: a prospective, randomised, controlled trial[J]. Laryngoscope, 2004, 114 (5): 923- 930.
doi: 10.1097/00005537-200405000-00027
21 陈国静, 蔡晓岚, 李学忠, 等. 慢性鼻-鼻窦炎-鼻息肉伴哮喘患者鼻内镜围手术期药物治疗[J]. 山东大学耳鼻喉眼学报, 2015, 29 (3): 35- 38.
doi: 10.6040/j.issn.1673-3770.0.2015.125
CHEN Guojing , CAI Xiaolan , LI Xuezhong , et al. Perioperative treatment in endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps and asthma[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2015, 29 (3): 35- 38.
doi: 10.6040/j.issn.1673-3770.0.2015.125
22 王丽, 张宇, 张华, 等. 加速康复外科理念在鼻窦外科手术的应用[J]. 山东大学耳鼻喉眼学报, 2018, 32 (5): 23- 26.
doi: 10.6040/j.issn.1673-3770.1.2018.013
WANG Li , ZHANG Yu , ZHANG Hua , et al. Enhanced recovery after surgery in sinus surgery[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2018, 32 (5): 23- 26.
doi: 10.6040/j.issn.1673-3770.1.2018.013
23 Chen FH , Deng J , Hong HY , et al. Extensive versus functional endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps and asthma: A 1-year study[J]. Am J Rhinol Allergy, 2016, 30 (2): 143- 148.
doi: 10.2500/ajra.2016.30.4271
24 Palmer JN , Conley DB , Dong RG , et al. Efficacy of endoscopic sinus surgery in the management of patients with asthma and chronic sinusitis[J]. Am J Rhinol, 2001, 15 (1): 49- 53.
doi: 10.2500/105065801781329400
25 Senior BA , Kennedy DW , Tanabodee J , et al. Long-term impact of functional endoscopic sinus surgery on asthma[J]. Otolaryngol Head Neck Surg, 1999, 121 (1): 66- 68.
doi: 10.1016/S0194-5998(99)70127-0
26 Seybt MW , McMains KC , Kountakis SE . The prevalence and effect of asthma on adults with chronic rhinosinusitis[J]. Ear Nose Throat J, 2007, 86 (7): 409- 411.
27 Kennedy DW . Prognostic factors, outcomes and staging in ethmoid sinus surgery[J]. Laryngoscope, 1992, 102 (Suppl 57): 1- 18.
28 Uri N , Cohen-Kerem R , Barzilai G , et al. Functional endoscopic sinus surgery in the treatment of massive polyposis in asthmatic patients[J]. J Laryngol Otol, 2002, 116 (3): 185- 189.
doi: 10.1258/0022215021910492
29 Lin DC , Chandra RK , Tan BK , et al. Association between severity of asthma and degree of chronic rhinosinusitis[J]. Am J Rhinol Allergy, 2011, 25 (4): 205- 208.
doi: 10.2500/ajra.2011.25.3613
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