基于囊泡组织Ki67、GM-CSF表达评估Messerklinger中鼻甲成形术对慢性鼻-鼻窦炎合并鼻息肉的效果

doi:10.6040/j.issn.1673-3770.0.2025.119

Abstract

Abstract: Objective To investigate the efficacy of Messerklinger turbinate reduction in treating chronic rhinosinusitis with nasal polyps(CRSwNP)and its effects on Ki67 expression and granulocyte-macrophage colony-stimulating factor(GM-CSF)expression in endoscopic tissue samples. Methods Eighty-six patients with chronic rhinosinusitis with nasal polyps(CRSwNP)were selected and randomly assigned using a random number table to either the control group(43 patients undergoing partial turbinectomy via endoscopic sinus surgery)or the observation group(43 patients undergoing Messerklinger turbinate reshaping). Comparison of clinical efficacy, nasal function ［nasal minimum cross-sectional area(NMCA), nasal cavity volume(NCV), distance from the nostril cavity to the anterior inferior(DCAN), and airway resistance(Raw)］, olfactory function, Ki67 expression in cystic tissue, GM-CSF expression in cystic tissue, complications, and recurrence rates. Results The clinical efficacy in the observation group was higher than that in the control group(P=0.034). At 3 months postoperatively, both groups showed increased NCV and NMCA, with the observation group exhibiting higher values than the control group(P=0.008,0.006). At 3 months postoperatively, both groups demonstrated decreased DCAN and Raw, with the observation group exhibiting lower levels(P=0.006,<0.001). At 3 months postoperatively, the olfactory function of both groups was improved, and the improvement degree in the observation group was higher than that in the control group(P=0.014). At 3 months postoperatively, Ki67 and GM-CSF positive expression levels were lower in the observation group than in the control group(P=0.016,0.023). From the time of surgery to follow-up, the recurrence rate was lower in the observation group than in the control group(P=0.034). Conclusion Messerklinger turbinate reduction significantly improves clinical outcomes in CRSwNP patients, effectively enhancing nasal function and olfactory function while reducing Ki67 and GM-CSF positive expression levels in cystic tissue and recurrence rates. This technique warrants clinical implementation.

Key words: Messerklinger middle turbinate reduction, Chronic rhinosinusitis with nasal polyps, Ki67, Granulocyte macrophage colony-stimulating factor, Nasal function, Olfactory function

CLC Number:

R765.41

FENG Sicong, YU Xiaolan, LOU Dan. Evaluation of the effect of Messerklinger middle turbinate plasty on chronic rhinosinusitis with nasal polyps based on the expression of Ki67 and GM-CSF in vesicular tissue[J].Journal of Otolaryngology and Ophthalmology of Shandong University, 2026, 40(3): 31-39.

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Evaluation of the effect of Messerklinger middle turbinate plasty on chronic rhinosinusitis with nasal polyps based on the expression of Ki67 and GM-CSF in vesicular tissue

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