JOURNAL OF SHANDONG UNIVERSITY (OTOLARYNGOLOGY AND OPHTHALMOLOGY)

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Effect of glucocorticoids on eotaxin expression in nasal polyps

ZHU Huabin, FENG Yunhai, YIN Shankai, ZHANG Yujun   

  1. Department of Otorhinolaryngology, Affiliated Sixth People′s Hospital,Shanghai Communication University, Shanghai 200233, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-02-25 Published:2006-02-25

Abstract: Objective： To explore the possible mechanism of glucocorticoids on nasal polyps. Methods： Eotaxin protein expression was measured by immunohistochemical techniques in 5 nasal polypous tissue specimens following 30 mg predisone oral doses per day for 7 days, 5 nasal polypous tissue specimens following 10 mg dexamethasone intravenous drops, 5 without any treatment and compared with the results from the inferior turbinate tissue specimens. Results： The protein level of eotaxin significantly elevated in the nasal polyps compared to the controls (P＜0.01), whereas it significantly decreased in the treatment group compared with the untreatment group(P＜0.01), and similar to the controls（P＞0.05）. Conclusion： Because eotaxin actively participates in the process of eosinophilic inflammation, glucocorticoids play an important role in antiinflammation by downregulation of eotaxin.

Key words: Chemotactic factors, eosinophil, Nasal polyps, Glucocorticoids

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